Abstract:Cardiac TRH (cTRH) induces LVH and fibrosis. The adiponectin Leptin induces TRH in CNS. We hypothesized that in obesity, the increase of cTRH induced by hyperleptinemia is responsible for the LVH, mostly attributed to pressure load. We studied obese hyperleptinemic with mild hypertension Agouti mice, and found LVH with higher (p<0.05) cTRH, fibrotic (I/III col,TGFβ) and hypertrophic (BNP,βMHC) marker genes vs lean (BL/6J). We normalized pressure in Agouti mice with hydroclorothiazide (20 mg/kg/day) since we… Show more
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