Abstinence-dependent transfer of lithium chloride-induced sucrose aversion to a sucrose-paired cue in rats

Harkness, John H.; Webb, Sierra M.; Grimm, Jeffrey W.

doi:10.1007/s00213-009-1755-5

Cited by 16 publications

(20 citation statements)

References 44 publications

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“…We also observed increases in both sucrose cue-reactivity and sucrose consumption after a 30-day period of forced abstinence, similar to previous reports of incubated responding and consumption (Harkness, Webb, & Grimm, 2010; Grimm et al, 2013). In contrast to context extinction, sucrose satiation did not reduce cue-reactivity when rats were provided sucrose in either home cages or operant conditioning chambers.…”

Section: Discussionsupporting

confidence: 91%

Extended exposure to environmental cues, but not to sucrose, reduces sucrose cue reactivity in rats

et al. 2015

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The present study examined the effect of extinction of sucrose-predictive contextual cues and/or sucrose satiation on the expression of sucrose cue-reactivity in a rat model of relapse. Context extinction was imposed by housing rats in their home cage or in the operant conditioning chamber for 17 hours prior to testing. For sucrose satiation, rats were allowed unlimited access to water or sucrose for 17 hours prior to testing. Cue-reactivity was assessed after either 1 (Day 1) or 30 (Day 30) days of forced abstinence from sucrose self-administration. An abstinence-dependent increase in sucrose cue-reactivity was observed in all conditions (“incubation of craving”). Context extinction dramatically reduced lever responding on both Day 1 and Day 30. Sucrose satiation had no significant effect on cue-reactivity in any condition. These results demonstrate that the context in which self-administration occurred maintains a powerful influence over cue-reactivity even after extended forced abstinence. In contrast, the primary reinforcer has little control over cue-reactivity. These findings highlight the important role of conditioned contextual cues in driving relapse behavior.

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Section: Discussionsupporting

confidence: 91%

Extended exposure to environmental cues, but not to sucrose, reduces sucrose cue reactivity in rats

et al. 2015

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“…This “incubation of craving” effect was similar to our previously published studies (e.g., Grimm et al 2008; Harkness et al 2009). When administered systemically, 1 and 5 µg/kg doses of the D1 receptor antagonist SCH 23390 only reduced cue reactivity in rats after 1 vs. 30 days into forced abstinence from sucrose self-administration.…”

Section: Discussionsupporting

confidence: 91%

“…This type of responding is less flexible in many ways, including that it is less susceptible to revaluation of the primary reinforcement contingency (Holland et al 2008). This effect may be related to the incubation of sucrose seeking as we recently found that revaluation of a sucrose-paired cue was abstinence dependent (Harkness et al 2009). …”

Section: Discussionmentioning

confidence: 98%

Effects of systemic or nucleus accumbens-directed dopamine D1 receptor antagonism on sucrose seeking in rats

et al. 2011

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Rationale Conditioned cues can elicit relapse to drug- and food-seeking behavior over prolonged periods of abstinence. If seeking behavior depends on mesolimbic dopamine D1 receptors, blocking these receptors should reduce seeking behavior. Objectives We examined the effects of either systemic or intra-nucleus accumbens administration of the D1 antagonist SCH 23390 on extinction responding (sucrose seeking) by rats either 1 or 30 days into forced abstinence. Materials and methods Rats self-administered 10% sucrose paired with a tone+light cue for 10 days. After either 1 or 30 days of forced abstinence, rats received systemic (0, 1, 5, or 25 µg/kg IP) or bilateral nucleus accumbens core or shell (0.3 or 0.6 µg/site) injections of SCH 23390 prior to extinction testing. Results Saline-treated rats responded more during extinction following 30 vs. 1 day of forced abstinence (“incubation of craving”). Systemic SCH 23390 reduced sucrose seeking after 1 day of forced abstinence, significantly reducing responding following pretreatment with 1, 5, and 25 µg/kg SCH 23390, but only 25 µg/kg significantly reduced sucrose seeking after 30 days of forced abstinence. SCH 23390 (0.3 or 0.6 µg/site) in the core or shell of the nucleus accumbens reduced sucrose seeking in all groups. Conclusion Nucleus accumbens D1 receptors are involved in sucrose seeking, but it is not clear if they are involved in the incubation of craving. The fact that D1 antagonism reduced sucrose seeking across an extended period of abstinence may be of use for development of treatment strategies for relapse.

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“…If the history effect were to be maintained in both of these comparisons, it might then be concluded that experience of DAD 2 antagonism during Extinction literally transferred to food pellets, devaluing their incentive value. Such transfer effects between primary and secondary reinforcers have been reported previously (Harkness et al, 2010). …”

Section: Discussionsupporting

confidence: 86%

The dopamine D2 antagonist eticlopride accelerates extinction and delays reacquisition of food self-administration in rats

Koerber

Goodman²,

Barnes³

et al. 2013

Behavioural Pharmacology

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Dopamine receptors are implicated in the reinforcing effects of food and drug reinforcement. The purpose of this study was to evaluate whether blocking D2 dopamine receptors during extinction (secondary reinforcement) would affect reacquisition of responding for food pellets (primary reinforcement). Food-restricted rats self-administered (FR1) food pellets in 1-h daily sessions for seven days. For the next seven days rats responded in extinction conditions. Prior to each extinction session rats were injected with saline or the dopamine D2 antagonist eticlopride (0.03 mg/kg, cs.c.). After the extinction phase, rats were allowed to reacquire food pellet self-administration in seven daily sessions, and received saline or eticlopride prior to each session. Four treatment groups were represented: (saline extinction, saline reacquisition); (eticlopride extinction, saline reacquisition); (saline extinction, eticlopride reacquisition); (eticlopride extinction, eticlopride reacquisition). Locomotor activity did not differ between eticlopride-treated and saline-treated rats throughout the study. Extinction was accelerated in eticlopride-treated rats. Eticlopride also delayed reacquisition of food self-administration compared to saline-treated rats. Rats administered eticlopride during extinction showed delayed reacquisition and a decreased response rate for food during the reacquisition phase. Indirectly reducing the value of a reinforcer in this way may provide a novel approach for reducing addiction-related food or drug self-administration behaviors.

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Abstinence-dependent transfer of lithium chloride-induced sucrose aversion to a sucrose-paired cue in rats

Cited by 16 publications

References 44 publications

Extended exposure to environmental cues, but not to sucrose, reduces sucrose cue reactivity in rats

Extended exposure to environmental cues, but not to sucrose, reduces sucrose cue reactivity in rats

Effects of systemic or nucleus accumbens-directed dopamine D1 receptor antagonism on sucrose seeking in rats

The dopamine D2 antagonist eticlopride accelerates extinction and delays reacquisition of food self-administration in rats

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