Absrobed Dose Estimates in Positron Emission Tomography Studies Based on the Administration of 18F-Labeled Radiopharmaceuticals.

Abstract

Absorbed doses were estimated after intravenous administration of 18F-labeled radiopharmaceuticals in Positron Emission Tomography (PET) studies. These radiopharmaceuticals, [18F]-2-Fluoro-2-Deoxy-D-Glucose (FDG), 6-[18F]Fluoro-L-Dopa (FDOPA) and 18F-5-Fluorodeoxyuridine (FdUR), are used in clinical research at the Cyclotron and Radioisotope Center of Tohoku University. Radiopharmaceutical biokinetic values were measured in humans or extrapolated from animal experiments. Selective organ uptake and rapid clearance of activity from the blood were observed. High activity in the bladder contents of humans was found. Calculations were made by the MIRD method, modified to account for the differences in physique and organ mass between the Caucasian Reference Man and the Japanese one. The bladder wall receives the highest dose (more than 1.23 x 10(-1) mGy/MBq) when any of these compounds are administered. Other organs receiving high doses are the heart, brain and kidneys from FDG; the kidneys and pancreas from FDOPA, and the kidneys and small intestine from FdUR. These organs received absorbed doses of more than 2.7 x 10(-2) mGy/MBq. Effective dose equivalents of 2.4 x 10(-2), 2.6 x 10(-2) and 3.3 x 10(-2) mSv/MBq were estimated in the intravenous administration of 18F-FDG, 18F-FDOPA and 18F-FdUR, respectively.

Whole-Body Biodistribution and Radiation Dosimetry of 18F-FP-(+)-DTBZ (18F-AV-133): A Novel Vesicular Monoamine Transporter 2 Imaging Agent

“…A more conservative dose calculation of 28.6 6 2.3 mSv/MBq was listed with a urinary interval of 4.8 h (Supplemental Table 1). This value is comparable to values from other PET tracers for clinical routine use (28,29) and makes 18 F-AV-133 suitable for clinical imaging applications, including longitudinal studies. Figure 3 shows the transverse brain images of a representative healthy subject at the level of the striatum, caudate head, and brain stem.…”

Synthesis and preliminary evaluation of [1-11C]hexanoate as a PET tracer of fatty acid metabolism

“…Because of the short half-life of' 'C and the significant amount of expired radioactivity as "CO 2 , radiationabsorbed doses were lower than those of ' 8F-labeled compounds. 20 …”

Maladie de Horton et atteintes artérielles extratemporales : utilité de la tomographie par émission de positons au 18FDG. À propos de trois observations et d'une revue de la littérature

“…Dans cette série, 9 patients sur 11 avaient un anévrisme aortique documenté alors qu'ils étaient considérés en rémission clinique [4]. De plus, par son innocuité démontrée sur des milliers d'examens, notamment en termes de risque cancérigène ou d'atteinte de la fonction gonadique, une TEP de contrôle peut être pratiquée chez un même patient, plusieurs fois par an [36][37][38]. Des études de coût-efficacité sont néanmoins nécessaires pour déterminer la fréquence optimale de ces contrôles.…”