Absorptive and Digestive Function of the Jejunum After Jejunoileal Bypass for Treatment of Human Obesity

Enzyme activities and morphological appearance in functioning and excluded segments of the small intestine after shunt operation for obesity.

“…Thus the total disaccharide hydrolysing capacity of the functioning piece of intestine had increased very prominently between the first and second operation. Adaptive increase of glucose absorption after bypass operation has also been demonstrated in man (Rehfeld et al, 1970;Iversen et al, 1976), although others have failed to confirm this (Fogel et al, 1976;Barry et al, 1977). At the second operation the ileal part of the functioning shunt showed enzyme activities that are normally found in the jejunum, with the exception of lactase, the levels of which remained low.…”

Effect of Jejunoileal Bypass on Plasma and Brain Amino Acids in the Rat

“…Changes in the plasma concentrations of amino acids after JIB in man have previously been reported (White et al, 1974;Fogel et al, 1976;Cha et al, 1979), and decreased concentrations of most essential and many nonessential amino acids were observed. In this study, the concentrations of all essential amino acids were low in plasma of JIB rats; however, only five of eight rats were significantly lower than in controls.…”

“…The causes of liver impairment after JIB are probably multifactorial, and malnutrition due to malabsorption of protein may be contributory (White et al, 1974). Several investigators have reported decreased concentrations of many plasma amino acids following JIB in man (White et al, 1974;Fogel et al, 1976;Cha et al, 1979) and these changes were most accentuated during the period of intense weight loss (White et al, 1974). Hepatic failure and coma have been reported following JIB, and death from liver failure occurred in 2.3% in the study of Weiseman and Johnson (1977).…”

Nursing management: jejunoileal bypass surgery

“…22 Average weight loss after the bypass is usually ten pounds per month for the first six months. Weight loss after bypass is attributed to the development of intestinal malabsorption, as evidenced by increased fecal loss of lipids and nitrogen (protein depletion) and by the secondary curtailment of appetite as evidenced by decreased food intake.…”

“…Weight loss after bypass is attributed to the development of intestinal malabsorption, as evidenced by increased fecal loss of lipids and nitrogen (protein depletion) and by the secondary curtailment of appetite as evidenced by decreased food intake. 22 Average weight loss after the bypass is usually ten pounds per month for the first six months. During the second six months, average weight loss is six pounds.…”