Absorption, serum levels and urinary excretion of inorganic sulfate after oral administration of sodium sulfate in the conscious rat

Krijgsheld, Klaas R.; Frankena, Henny; Scholtens, Egbert; Zweens, J; Mulder, Gerard J.

doi:10.1016/0304-4165(79)90039-4

Cited by 55 publications

(15 citation statements)

References 10 publications

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“…Slight reduction in serum sulphur with increased DCAD level might be because of dietary concentration. Moreover, S balance is regulated renally not intestinally thus increased intake, increased the blood serum S (Krijgsheld et al, 1979). These findings are in concordance with Delaquiz and Block (1995).…”

Section: Serum Mineralssupporting

confidence: 82%

Nutrient intake, acid base status and growth performance of growing male buffalo calves fed varying level of dietary cation anion difference

2007

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Section: Serum Mineralssupporting

confidence: 82%

Nutrient intake, acid base status and growth performance of growing male buffalo calves fed varying level of dietary cation anion difference

2007

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“…In general, SRB were found in greatest density in distal segments of the mouse intestine, which also contains large numbers of sulfomucin-containing goblet cells. We have obtained preliminary evidence that significant concentrations of endogenously secreted sulfate are present in the cecum and colon (B. Deplancke, K. Finster, V. J. McCracken, R. I. Mackie, and H. R. Gaskins, unpublished data), while others (24) have demonstrated that dietary sulfate is quantitatively absorbed in proximal segments of the mouse intestine. Differential sulfate concentrations in the colon compared to the small intestine may influence SRB population profiles based on the bioenergetic efficiency of community members.…”

Section: Discussionmentioning

confidence: 93%

Molecular Ecological Analysis of the Succession and Diversity of Sulfate-Reducing Bacteria in the Mouse Gastrointestinal Tract

Deplancke¹,

Hristova

Oakley³

et al. 2000

Appl Environ Microbiol

142

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Intestinal sulfate-reducing bacteria (SRB) growth and resultant hydrogen sulfide production may damage the gastrointestinal epithelium and thereby contribute to chronic intestinal disorders. However, the ecology and phylogenetic diversity of intestinal dissimilatory SRB populations are poorly understood, and endogenous or exogenous sources of available sulfate are not well defined. The succession of intestinal SRB was therefore compared in inbred C57BL/6J mice using a PCR-based metabolic molecular ecology (MME) approach that targets a conserved region of subunit A of the adenosine-5-phosphosulfate (APS) reductase gene. The APS reductase-based MME strategy revealed intestinal SRB in the stomach and small intestine of 1-, 4-, and 7-day-old mice and throughout the gastrointestinal tract of 14-, 21-, 30-, 60-, and 90-day-old mice. Phylogenetic analysis of APS reductase amplicons obtained from the stomach, middle small intestine, and cecum of neonatal mice revealed that Desulfotomaculum spp. may be a predominant SRB group in the neonatal mouse intestine. The toxic gas hydrogen sulfide (H 2 S) is generated from sulfate during anaerobic respiration by sulfate-reducing Archaea and Bacteria (21, 58). A possible link between H 2 S and chronic intestinal disorders has been evoked by data indicating increased numbers of intestinal sulfate-reducing bacteria (SRB) and rates of sulfidogenesis in inflammatory bowel disease (IBD) patients compared to healthy humans (12, 37). Hydrogen sulfide selectively impairs the oxidation of n-butyrate by colonic epithelial cells (42). Because membrane lipid biosynthesis, ion absorption, mucin synthesis, and detoxification processes in colonocytes depend on the oxidation of n-butyrate, diminished n-butyrate metabolism is likely to compromise the epithelial cell barrier (42). Sulfide-induced damage of the epithelial barrier function would promote translocation of bacterial and food antigens, resulting in local inflammatory responses to normally benign antigens, an outcome consistent with histopathological features of IBD (16, 61). Chronic exposure to H 2 S might also perturb normal cycles of epithelial renewal in the intestine, thereby predisposing to proliferative disorders such as colon cancer.Intestinal sulfate can be derived either from exogenous sources, namely sulfate in drinking water and dietary foodstuffs, or from endogenous sources such as sulfated mucins (sulfomucins), sulfate-conjugated bile, and chondroitin sulfate. Use of chemically bound, endogenous sulfate by SRB is facilitated through interactions with sulfatase-harboring bacteria (e.g., Bacteroides spp. [56]). Most goblet cells, a differentiated epithelial cell subtype that produces mucins, generate sulfomucins (22). The degree of sulfation, however, increases from proximal to distal segments of the intestine and is highest in those segments harboring dense bacterial populations, such as the cecum and colon (9,20).The ecology and taxonomy of intestinal SRB and their metabolic activities remain uncharacterized. Most studies of...

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“…Urine urea nitrogen was measured using a commercial kit (1770-500; Thermo Electron Corp, Melbourne, Australia). Urinary sulfate was measured by reaction with TCA and barium chloride and was read spectrophotometrically at 360 nm (12). Urinary phosphate levels were measured using a commercial kit (P7516; Pointe Scientific Inc, Canton, MI).…”

Section: Methodsmentioning

confidence: 99%

The Production of p-Cresol Sulfate and Indoxyl Sulfate in Vegetarians Versus Omnivores

Patel

Luo

Plummer

et al. 2012

Clinical Journal of the American Society of Nephrology

184

140

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SummaryBackground and objectives The uremic solutes p-cresol sulfate (PCS) and indoxyl sulfate (IS) are generated by colon bacteria acting on food components that escape absorption in the small bowel. The production of these potentially toxic compounds may thus be influenced by diet. This study examined whether production of PCS and IS is different in vegetarians and omnivores.Design, setting, participants, & measurements The production of PCS and IS was assessed by measuring their urinary excretion rates in participants with normal kidney function. Studies were carried out in 15 vegetarians and 11 individuals consuming an unrestricted diet. Participants recorded food intake over 4 days and collected urine over the final 2 days of each of two study periods, which were 1 month apart.Results Average PCS excretion was 62% lower (95% confidence interval [95% CI], 15-83) and average IS excretion was 58% lower (95% CI, 39-71) in vegetarians than in participants consuming an unrestricted diet. Food records revealed that lower excretion of PCS and IS in vegetarians was associated with a 69% higher (95% CI, 20-139) fiber intake and a 25% lower (95% CI, 3-42) protein intake. PCS and IS excretion rates varied widely among individual participants and were not closely correlated with each other but tended to remain stable in individual participants over 1 month.Conclusions PCS and IS production rates are markedly lower in vegetarians than in individuals consuming an unrestricted diet.

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Absorption, serum levels and urinary excretion of inorganic sulfate after oral administration of sodium sulfate in the conscious rat

Cited by 55 publications

References 10 publications

Nutrient intake, acid base status and growth performance of growing male buffalo calves fed varying level of dietary cation anion difference

Nutrient intake, acid base status and growth performance of growing male buffalo calves fed varying level of dietary cation anion difference

Molecular Ecological Analysis of the Succession and Diversity of Sulfate-Reducing Bacteria in the Mouse Gastrointestinal Tract

The Production of p-Cresol Sulfate and Indoxyl Sulfate in Vegetarians Versus Omnivores

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