Absorption pharmacokinetics and feasibility of intranasal dexmedetomidine in patients under general anaesthesia
Suvi‐Maria Tiainen,
Brian J. Anderson,
Ella Rinne
et al.
Abstract:BackgroundThe use of intranasal dexmedetomidine is hampered by a limited understanding of its absorption pharmacokinetics.MethodsWe examined the pharmacokinetics and feasibility of intranasal dexmedetomidine administered in the supine position to adult patients undergoing general anaesthesia. Twenty‐eight patients between 35 and 80 years of age, ASA 1–3 and weight between 50 and 100 kg, who underwent elective unilateral total hip or knee arthroplasty under general anaesthesia were recruited. All patients recei… Show more
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