2004
DOI: 10.1385/bter:98:2:159
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Absorption of the Biomimetic Chromium Cation Triaqua-Μ<SUB>3</SUB>-oxo-Μ-hexapropionatotrichromium(III) in Rats

Abstract: The cation [Cr3O(O2CCH2CH3)6(H2O)3]+ has been shown in vitro to mimic to the oligopeptide chromodulin's ability to stimulate the tyrosine kinase activity of insulin receptor and shown in healthy and type 2 diabetic model rats to increase insulin sensitivity and decrease plasma total and low-density lipoprotein cholesterol and triglycerides concentrations. However, the degree to which the complex is absorbed after gavage administration to rats had not been previously determined. The biomimetic cation at nutriti… Show more

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Cited by 59 publications
(29 citation statements)
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“…Significantly higher Cr and Zn levels and lower levels of Cu were reported in the scalp hair of patients with malignant tumours than in the scalp hair of healthy donors (Kolmogorov et al 2000), evidencing that higher hair Cr and Zn contents indicated increased cancer risk. Moreover, Cr and Zn had been reported to be significantly higher in the blood of breast cancer patients as compared with healthy donors (Singh and Garg 1998), and had been significant experimental evidence that Cr stimulate oxygen radical production which induces DNA damage (Clodfelder et al 2004). Breast cancer mortality was found to be strongly contributed by Cr, followed by Cd and Zn, while for prostate cancer, Cd revealed the strongest contribution followed by Zn and Cr (Hayes 1997;Drasch et al 2005;Schrauzer 2006).…”
Section: Resultsmentioning
confidence: 99%
“…Significantly higher Cr and Zn levels and lower levels of Cu were reported in the scalp hair of patients with malignant tumours than in the scalp hair of healthy donors (Kolmogorov et al 2000), evidencing that higher hair Cr and Zn contents indicated increased cancer risk. Moreover, Cr and Zn had been reported to be significantly higher in the blood of breast cancer patients as compared with healthy donors (Singh and Garg 1998), and had been significant experimental evidence that Cr stimulate oxygen radical production which induces DNA damage (Clodfelder et al 2004). Breast cancer mortality was found to be strongly contributed by Cr, followed by Cd and Zn, while for prostate cancer, Cd revealed the strongest contribution followed by Zn and Cr (Hayes 1997;Drasch et al 2005;Schrauzer 2006).…”
Section: Resultsmentioning
confidence: 99%
“…As noted in the present study, significantly higher Cr and Zn levels and lower levels of Cu were reported in the scalp hair of patients with malignant tumors than in the scalp hair of healthy donors [36,37], an evidence that higher hair Cr and Zn contents indicated increased cancer risk. Moreover, Cr and Zn had been reported to be significantly higher in the blood of breast cancer patients as compared with healthy donors [30], and had been significant experimental evidence that Cr stimulate oxygen radical production, which induces DNA damage [38]. Breast cancer mortality was found to be strongly contributed by Cr, followed by Cd and Zn, whereas for prostate cancer, Cd revealed the strongest contribution followed by Zn and Cr [19,21,27].…”
Section: Discussionmentioning
confidence: 99%
“…Various complexes of trivalent Cr such as Cr-picolinate, Cr-histidinate, Cr-nicotinate, Cr-phenylalanine, and Cr-methionine have been patented and manufactured, and some of these forms have been marketed as dietary supplements worldwide [13][14][15]. However, information about their bioavailability and bioactivity in animals and humans is largely unknown.…”
Section: Introductionmentioning
confidence: 99%
“…Few studies have evaluated Cr effect on central nervous system and cognition in diabetic humans and animals. It was hypothesized that learning disability resulting from impairment in glucose metabolism and insulin action in type 2 diabetes could be ameliorated by supplemental Cr through restoring cerebral tissue Cr reserves and enhancing cerebral glucose metabolism, which may vary by its source and level [13,14]. The objective of this experiment was therefore to investigate two new organic complexes of Cr, 3 ] + NO 3 − ) on glucose metabolism and memory acquisition in a diabetic type 2 rat model induced by high-fat feeding.…”
Section: Introductionmentioning
confidence: 99%