Absorption of sperm antigen from the vagina in guinea pigs

Isojima, Shinzo; Ashitaka, Yoshio

doi:10.1016/0002-9378(64)90498-3

Cited by 10 publications

(1 citation statement)

References 11 publications

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“…Recently, Hunter & Nornes (1969) recognized that a sperm-coating antigen isolated from rabbit seminal plasma possessed the ability to block fertilization. Furthermore, Isojima & Ashitaka (1964) reported that some sperm antigens might be absorbed from the vagina or cervix to induce antibody production and studied the inhibition of fertility in the female guinea-pig. These facts suggest that a sperm-coating antigen may be released from the spermatozoa in the female reproductive tract and that such a phenomenon has some relation¬ ship to the sperm capacitation process.…”

Section: Introductionmentioning

confidence: 99%

Studies on Sperm Capacitation

Aonuma¹,

Mayumi²,

Suzuki³

et al. 1973

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During incubation of guinea-pig spermatozoa in Ca-free Krebs-Ringer phosphate buffer, substances were released into the medium which were subsequently separated on Sephadex G-200 into two major fractions, Fr. I and Fr. II. The macromolecular Fr. I increased with sperm maturation and the fraction was shown to possess four different antigens. The amount of Fr. I. released from spermatozoa during incubation in the uterus was apparently influenced by the hormonal environment of the female reproductive tract. The fraction showed decapacitating activity, and decapacitated spermatozoa treated with Fr. I were capable of recapacitation after a second uterine incubation period. It was concluded that Fr. I was the decapacitation factor in guinea-pig semen.

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Section: Introductionmentioning

confidence: 99%