Absorption of Radioactive Sodium From the Intestinal Tract of Man. I. Effect of Intestinal Motility. Ii. Effect of an Organomercurial*†

Groisser, Victor W.; Farrar, John T.

doi:10.1172/jci104183

Cited by 24 publications

(7 citation statements)

References 17 publications

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“…Cummins and Almy (1953) failed to alter, by using banthine, the glucose tolerance test when glucose was introduced in the duodenum, and Fordtran, Soergel, and Ingelfinger (1962) found that atropinization increased the intestinal absorption of xylose. Groissier and Farrar (1960) conclude that hypomotility probably does not play a critical role in the absorption of isotopic sodium in the normal small intestine, although Higgins, Code, and Orvis (1956) found rather opposite results. Moreover studies on water and ions absorption done with the proximal occluding balloon (Phillips and Summerskill, 1967) and with the triple-lumen tube (Rambaud, personal communication) provided similar results.…”

Section: Discussionmentioning

confidence: 92%

Absorption of glucose, sodium, and water by the human jejunum studied by intestinal perfusion with a proximal occluding balloon and at variable flow rates

Modigliani¹,

Bernier²

1971

Gut

112

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SUMMARY A perfusion technique with a proximal occluding balloon has been used to study the absorption of glucose, sodium, and water from the human jejunum at different rates of flow. The absorption of glucose and water was significantly higher with the balloon deflated than inflated, probably because of reflux of infused solution above the point of infusion. Above the inflated balloon 0 to 4.2 ml/min of endogenous secretions could be recovered. Increasing flow rates increase the glucose absorption rate; a single relationship could be found between the glucose load and glucose absorption rate, and single values for the maximum velocity and for the half saturating load were calculated whatever the infusing rate and the initial glucose concentration. The stimulating effect of glucose on water and sodium movement increases gradually when the initial Sugar concentration varies from 14 to 133 mM/1. Above this concentration a drop in water and sodium movement is observed, although the initial sodium concentration is kept constant. High flow rate3 result in a decrease of water absorption and an increase in sodium and potassium secretion rates.Intestinal perfusion techniques have been widely used to study the absorption of sugars, water, and electrolytes in man (Holdsworth and Dawson, 1964;Gray and Ingelfinger, 1966; Whalen, Harris, Geenen, and Soergel, 1966;McMichael, Webb, and Dawson, 1967;Fordtran, Rector, and Carter, 1968). Neverthtless a controversy still persists about the use of a double or a triple lumen tube (Sladen and Dawson, 1968;Fordtran, 1969). Moreover, although a recent paper deals with the effects of flow rates on the absorption of glucose (Sladen and Dawson, 1969b), the exact consequences of varying flow rates have not yet been reported, especially with regard to the kinetics of glucose absorption and the movement of water and electrolytes. The present study was undertaken to investigate these two problems further. MethodsTwenty-nine subjects, aged between 25 and 65 years, were studied. They were either patients with minor

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Section: Discussionmentioning

confidence: 92%

Absorption of glucose, sodium, and water by the human jejunum studied by intestinal perfusion with a proximal occluding balloon and at variable flow rates

Modigliani¹,

Bernier²

1971

Gut

112

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“…In celiac disease, May and McCreary [1940] also reported a decrease in glucose absorption rate associated with hypomotility. The appearance rate of radioactive sodium in the blood indicated that, when motility of small intestine in healthy humans was depressed by the administration of propantheline or methantheline bromide, radio-sodium absorption was decreased [Groisser and Farrar, 1960;Higgins et al, 1956]. The reduction of absorption of isotopic water and sodium from intestine in patients with non-tropical sprue was considered due to hypomotility [Higgins et al, 1957].…”

Section: Discussionmentioning

confidence: 99%

ROLE OF LYMPHATIC SYSTEM IN WATER AND SOLUTE TRANSPORT FROM RAT INTESTINE IN VITRO

Lee

1969

Exp Physiol

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The results of the present study confirm previous observations and provide further evidence that water and solute are primarily transported from the intestine by the lymphatic system of rat jejunum in vitro, regardless of the nature of the serosal bathing medium (moist air, mineral oil or Ringer solution), or degree of intestinal motility. The transport of fluid by the venous system was negligible under all circumstances so far observed. Venous transport occurred only over a brief duration but lymphatic transport continued with little diminution in rate for at least 40 min. Lymph flow decreased with the increase of mucosal fluid osmolarity but was not affected by changing serosal fluid osmolarity. Lymph was always isosmotic with the mucosal fluid whether the latter was hypo-, iso-, or hypertonic. The composition of lymph with respect to concentrations of glucose; Na, K and Cl was the same as that of the absorbed fluid. The glucose concentration in the lymph was closely related to that in the bathing fluid on the mucosal side, rather than to that on the serosal side. It is concluded that the formation of lymph in the intestine is closely associated with water and solute absorption.

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“…[ 1 ] suggested that methanteline bromide slowed the absorption of the isotopes by reducing the area of the mucosa to which they were exposed. I n contrast, Groissier et al [2] concluded that the changes in absorption were mainly attributable to the anticholinergic drug and not to altered intestinal motility. Fordtran el al.…”

Section: Relationship Between Mean Transit Time and Net Movements Of mentioning

confidence: 93%

Effects of Cholecystokinin and Metoclopramide on Jejunal Movements of Water and Electrolytes and on Transit Time of Luminal Fluid in Man

Matuchansky

Huet

Mary

et al. 1972

Eur J Clin Investigation

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Abstract. The effects of cholecystokinin and metoclopramide upon jejunal transit time of luminal fluid, net movements of water and electrolytes and unidirectional fluxes of sodium were studied in 11 normal subjects, each one being his own control. An intestinal perfusion technique with a four‐lumen tube was used. This allowed a simultaneous determination of mean transit time and absorption rate of water and electrolytes through a 35 cm segment of jejunum, (a) Cholecystokinin induced a significant decrease in mean transit time of fluid along the test segment. This effect was primarily due to a striking reduction (40% or more) in the mean diameter of the intestinal lumen, (b) Simultaneously there was a significant increase in net water, sodium and chloride secretion into the lumen, whereas net transport of potassium and bicarbonate was not affected. The lumen‐to‐blood unidirectional flux of sodium was obviously reduced but the opposite flux did not significantly change, (c) Similar changes in water and electrolyte movements were observed in subjects in whom transit time was primarily decreased by metoclopramide. (d) A close correlation was found between changes in transit time and net water and sodium transport into the lumen, in both cholecystokinin and metoclopramide studies. These results suggest that intestinal hypermotility may result, per se, in an increased secretion rate of water and electrolytes across the proximal small bowel. The implication of these findings in clinical conditions associating watery diarrhoea with intestinal hypermotility is discussed.

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Absorption of Radioactive Sodium From the Intestinal Tract of Man. I. Effect of Intestinal Motility. Ii. Effect of an Organomercurial*†

Cited by 24 publications

References 17 publications

Absorption of glucose, sodium, and water by the human jejunum studied by intestinal perfusion with a proximal occluding balloon and at variable flow rates

Absorption of glucose, sodium, and water by the human jejunum studied by intestinal perfusion with a proximal occluding balloon and at variable flow rates

ROLE OF LYMPHATIC SYSTEM IN WATER AND SOLUTE TRANSPORT FROM RAT INTESTINE IN VITRO

Effects of Cholecystokinin and Metoclopramide on Jejunal Movements of Water and Electrolytes and on Transit Time of Luminal Fluid in Man

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