Absorption of phenolsulfonphthalein as a model across the mesenteric surface in rats to determine the drug absorption route after intraperitoneal administration

Nishida, Koyo; Nose, Seiichi; Kuma, Akiko; Mukai, Takahiro; Nakashima, Makoto; Sasaki, Hidetada; Nakamura, Junzo

doi:10.1211/0022357023385

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…Therefore, it may be useful to determine the changes in disposition characteristics of a marker substance to assess the degree of peritoneal damage because absorption of a marker substance in the peritoneal cavity, unlike endogenous substances such as glucose, is independently detectable and quantification of a marker substance is easy and inexpensive. We previously developed a method for application of drugs to the surface of intraperitoneal organs such as the liver (14)(15)(16)(17)(18)(19)(20)(21), kidney (22,23), stomach (24,25), mesenteric membrane (26), caecum (27), and intestine (20,28) and absorption of drugs from the surface of these organs was pharmacokinetically analyzed. We also reported on the absorption of drugs from the peritoneal cavity (29).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Enhanced Peritoneum Permeability in Methylglyoxal-treated Rats as a Diagnostic Method for Peritoneal Damage

et al. 2007

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Section: Introductionmentioning

confidence: 99%

Evaluation of Enhanced Peritoneum Permeability in Methylglyoxal-treated Rats as a Diagnostic Method for Peritoneal Damage

et al. 2007

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The Complex Relationship Between Microbiota, Immune Response and Creeping Fat in Crohn’s Disease

Suau

Pardina

Domènech

et al. 2021

Journal of Crohn's and Colitis

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In the last decade, there has been growing interest in the pathological involvement of hypertrophic mesenteric fat attached to the serosa of the inflamed intestinal segments involved in Crohn's disease, known as creeping fat. In spite of its protective nature, creeping fat harbours an aberrant inflammatory activity which, in an already inflamed intestine, may explain why creeping fat is associated with a greater severity of Crohn’s disease. The transmural inflammation of Crohn’s disease facilitates the interaction of mesenteric fat with translocated intestinal microorganisms, contributing to the activation of the immune response. This may be not the only way in which microorganisms alter the homeostasis of this fatty tissue: intestinal dysbiosis may also impair xenobiotic metabolism. All these Crohn’s disease-related alterations have a functional impact on nuclear receptors such as the farnesoid X receptor or the peroxisome proliferator-activated receptor γ, which are implicated in the regulation of immune response, adipogenesis and the maintenance of barrier function, as well as on the creeping fat production of inflammatory influencers such as adipokines. The dysfunction of creeping fat worsens the inflammatory course of Crohn’s disease and may favour intestinal fibrosis and fistulizing complications. However, our current knowledge of the pathophysiology and pathogenic role of creeping fat is controversial and a better understanding might provide new therapeutic targets for Crohn’s disease. We aim to review and update the key cellular and molecular alterations involved in this inflammatory process that link the pathological components of Crohn’s disease with the development of creeping fat.

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Peritoneal Dialysis Fluid–Induced Angiogenesis in Rat Mesentery Is Increased by Lactate in the Presence or Absence of Glucose

Albrektsson

Bazargani²,

Wieslander³

et al. 2006

ASAIO Journal

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Angiogenesis may be an important mechanism behind the functional deterioration of the peritoneum leading to ultrafiltration failure in peritoneal dialysis. The present study was designed to compare the angiogenic properties of lactate-, bicarbonate-, and pyruvate-buffered fluids, evaluated separately with and without glucose. Five different fluids (lactate and bicarbonate with and without 2.5% glucose and pyruvate without glucose) were studied for 5 weeks of twice-daily injections in rats. The respective buffers (40 mmol/l) were adjusted to pH 7.2, and sodium, chloride, calcium, and magnesium were present at standard concentrations. The mesenteric window model, based on observation of the translucent peritoneal sections of the small intestine mesentery, was used for immunohistochemical imaging of microvessels (RECA-1 antigen) and macrophages (ED1 and ED2 antigens). All fluids induced angiogenesis as compared with untreated controls. The lactate-buffered fluids induced larger vascularized zones than did their bicarbonate- and pyruvate-buffered counterparts. Angiogenesis was accompanied by a local recruitment of ED1 macrophages from blood. Addition of glucose to the lactate- and bicarbonate-buffered fluids did not seem to alter their pro-angiogenic properties. In conclusion, intraperitoneal exposure to lactate buffer, compared with bicarbonate, stimulates angiogenesis in the presence or absence of glucose.

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Absorption of phenolsulfonphthalein as a model across the mesenteric surface in rats to determine the drug absorption route after intraperitoneal administration

Cited by 4 publications

References 16 publications

Evaluation of Enhanced Peritoneum Permeability in Methylglyoxal-treated Rats as a Diagnostic Method for Peritoneal Damage

Evaluation of Enhanced Peritoneum Permeability in Methylglyoxal-treated Rats as a Diagnostic Method for Peritoneal Damage

The Complex Relationship Between Microbiota, Immune Response and Creeping Fat in Crohn’s Disease

Peritoneal Dialysis Fluid–Induced Angiogenesis in Rat Mesentery Is Increased by Lactate in the Presence or Absence of Glucose

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