Absorption of Levothyroxine When Coadministered with Various Calcium Formulations

Zamfirescu, I; Carlson, Harold E.

doi:10.1089/thy.2010.0296

Cited by 58 publications

(41 citation statements)

References 15 publications

(26 reference statements)

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“…Other pharmacokinetic PDDI occurred when the drugs were administered with calcium carbonate, which is mainly used in the treatment of osteoporosis, it reduces the absorption of other medications and, therefore, the bioavailability of various drugs. 28,29 The pharmacokinetic interactions during absorption are easy to manage. In most cases, it can be done simply by changing the medication administration timing to ensure the absorption of both drugs.…”

Section: Discussionmentioning

confidence: 99%

Potential high-risk drug-drug interactions among elderly outpatients with dementia: a cross-sectional stud

Ferreira¹,

Diniz²,

Souza³

et al. 2015

Geriatr. Gerontol. Aging

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OBJECTIVE:To analyse the occurrence of potential high-risk drug-drug interactions in elderly individuals with dementia. METHODS: The sample was chosen from a geriatric outpatient clinic of the Multidisciplinary Center for the Elderly in the University Hospital of Brasília. This cross-sectional study included patients aged 60 or older with a diagnosis of dementia. The prescriptions were analyzed using the Lexi-Interact® database to identify possible potential drug-drug interactions. RESULTS: The study included 97 participants. Sixty-one patients (62.9%) had at least one clinically important potential drug-drug interactions (risks C and D). Of the 264 interactions identified, 23 (8.7%) were classified as risk D, 14 were pharmacodynamics and nine pharmacokinetic. CONCLUSION: The results of this study suggest an increased frequency in the occurrence of clinically significant potential drug-drug interactions in dementia patients. This reinforces the need for drug-drug interaction studies in specific populations.

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Section: Discussionmentioning

confidence: 99%

Potential high-risk drug-drug interactions among elderly outpatients with dementia: a cross-sectional stud

Ferreira¹,

Diniz²,

Souza³

et al. 2015

Geriatr. Gerontol. Aging

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“…Some foods (espresso coffee, soybean protein, dietary fiber), and drugs (ferrous and calcium salts, bile acid sequestering agents, sucralfate, aluminium hydroxide, proton pump inhibitors) can decrease L-T4 intestinal absorption (200,203) (D,B). In these cases, simultaneous ingestion with L-T4 should be avoided.…”

Section: How To Approach Hypothyroid Patients With Persistently High mentioning

confidence: 99%

Clinical practice guidelines for the management of hypothyroidism

Brenta

Vaisman

Sgarbi

et al. 2013

Arq Bras Endocrinol Metab

124

123

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Introduction: Hypothyroidism has long been known for its effects on different organ systems, leading to hypometabolism. However, subclinical hypothyroidism, its most prevalent form, has been recently related to cardiovascular risk and also to maternal-fetal complications in pregnant women. Objectives: In these clinical practice guidelines, several aspects of this field have been discussed with the clear objectives of helping physicians treat patients with hypothyroidism, and of sharing some of our Latin American-based clinical experience. Materials and methods: The Latin American Thyroid Society commissioned a Task Force on Hypothyroidism to develop evidence-based clinical guidelines on hypothyroidism. A systematic review of the available literature, focused on the primary databases of MedLine/PubMed and Lilacs/SciELO was performed. Filters to assess methodological quality were applied to select the best quality studies. The strength of recommendation on a scale from A-D was based on the Oxford Centre for Evidence--based Medicine, Levels of Evidence 2009, allowing an unbiased opinion devoid of subjective viewpoints. The areas of interest for the studies comprised diagnosis, screening, treatment and a special section for hypothyroidism in pregnancy. Results: Several questions based on diagnosis, screening, treatment of hypothyroidism in adult population and specifically in pregnant women were posed. Twenty six recommendations were created based on the answers to these questions. Despite the fact that evidence in some areas of hypothyroidism, such as therapy, is lacking, out of 279 references, 73% were Grade A and B, 8% Grade C and 19% Grade D. Conclusions: These evidence-based clinical guidelines on hypothyroidism will provide unified criteria for management of hypothyroidism throughout Latin America. Although most of the studies referred to are from all over the world, the point of view of thyroidologists from Latin America is also given. Arq Bras Endocrinol Metab. 2013;57(4):265-99

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“…Concomitant use of both agents may cause or exacerbate hypercalcemia (21) 2 (2.4) Calcium + levothyroxine B The administration of calcium and levothyroxine at the same time was found to reduce levothyroxine absorption (33) and was associated with a significant reduction (17 pmol/L at baseline to 15 pmol/L during the calcium period) in mean serum free thyroxine (11,12, …”

Section: Discussionmentioning

confidence: 99%