Absorption of Insulin by Nasal Mucous Membrane.

Collens, William S.; Goldzieher, Max A.

doi:10.3181/00379727-29-6067

Cited by 9 publications

(2 citation statements)

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“…The reason behind this finding is that insulin is a large polypeptide hormone that has little permeability through the nasal mucosa, broken down by intrinsic mucosal enzymes and via mucociliary transport, transported to the digestive system where it is degraded. 14,15 In fact, the aforementioned reasons stand for nasal insulins’ limited clinical use in diabetes mellitus. With the results obtained from this study, it could be speculated that the same dose of topical intranasal insulin in human trials would not result in hypoglycemia in subjects.…”

Section: Discussionmentioning

confidence: 99%

Topical Intranasal Insulin Enhances Healing of Nasal Mucosa: An Experimental Animal Study

Külekçi

Özer

Önen

et al. 2022

Am J Rhinol�Allergy

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Objective Aim of this study was to evaluate the effect of topical intranasal insulin on healing of nasal mucosa in a rat model. Methods Forty-eight Wistar rats, weighing between 250 and 300 g and aged 10–12 weeks were used and randomized into two equal groups. 1.9 mm curette was introduced through the left nostril and 1.9 mm mucosa from the left nasal septum was curetted. Postoperatively, animals in the control group received 1 mL of physiologic saline, 3 times a day in a nasal irrigation fashion. Animals in the experimental group received 1 mL of 5 IU/mL regular insulin in saline solution. Subjects were sacrificed after 5, 10, and 15 days and macroscopic and histomorphometric evaluations were performed. Results There were no mucosal synechiae and septal perforation macroscopically. Histological examination revealed that the defect size reduction was 21% in the saline group versus 56% in the insulin group on the fifth day ( p = 0.006). There was 62% defect reduction in the saline group versus 79% in the insulin group on the 10th day ( p = 0.034). On the 15th day, only 67% of saline group animals had complete defect closure, whereas 100% of animals treated with insulin had complete closure (92% vs 100% mucosal defect reduction, p = 0.036). Both edema and inflammation were less in the insulin group on 15th day ( p = 0.006; p = 0.023, respectively). Conclusion The results from this study support the safety and efficacy of topical insulin on wound healing in the literature. This study could guide further experimental studies that examine human sinonasal wound healing.

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Section: Discussionmentioning

confidence: 99%

Topical Intranasal Insulin Enhances Healing of Nasal Mucosa: An Experimental Animal Study

Külekçi

Özer

Önen

et al. 2022

Am J Rhinol�Allergy

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“…insulin through nasal mucous membranes was studied in human diabetics with insulin solutions containing saponin [4]. Although effective, this formulation produced congestion in the nasal mucosa.…”

Section: Time (Minutes)mentioning

confidence: 99%

Delivery of hormones: some new concepts

Hermens

1992

Pharmaceutisch Weekblad Scientific Edition

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Some new concepts in the delivery of hormones are described. Transmucosal or transdermal penetration of hormones can be facilitated, often by the use of absorption enhancers. Studies of nasal insulin delivery are described. Recently developed iontophoretic delivery devices can be useful for pulsatile transdermal administration of peptide hormones. A self-regulating delivery system releasing insulin in response to glucose levels is described. A vaginal ring releasing ethinylestradiol and 3-ketodesogestrel is a new concept in long-acting contraception. A nasal estradiol formulation, containing the absorption enhancer dimethyl-beta-cyclodextrin, is an interesting alternative to oral and transdermal delivery of female sex hormones.

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