Absorption of Implanted Solid Drug

Intramuscular Administration of Paliperidone Palmitate Extended-Release Injectable Microsuspension Induces a Subclinical Inflammatory Reaction Modulating the Pharmacokinetics in Rats

“…For solid sustained‐release parenteral depots, it is generally assumed that the drug absorption rate is predominantly controlled by the dosage form itself (e.g., particle size, solubility, etc. ), therefore implying dissolution rate‐limited pharmacokinetics (as opposed to absorption or perfusion rate limitation) . However, the situation in vivo is likely to be more complicated, especially because very long exposures to living (viz.…”

“…), therefore implying dissolution rate-limited pharmacokinetics (as opposed to absorption or perfusion rate limitation). 11,12 However, the situation in vivo is likely to be more complicated, especially because very long exposures to living (viz. reactive) biological tissues can be expected for these slowly dissolving drug particles.…”

Effect of Temperature on Absorption Rates of Drug Implants

“…ERRATUM I n the paper titled "Production of Pyridoxine and Niacin by Chlorella vulgaris and C. pyrenoidosa" (1). …”

Chemical and biological evaluation of the release of aldicarb from granular formulations

“…For example, successful pharmaceutical formulations for oral administration have been prepared by coating a drug, embedding it in a wax-fat vehicle or porous plastic base, binding the active substance to ion exchange resins, complexing it with a colloidal material, fusing it into a pellet, or encapsulating it (Lazarus and Cooper, 1961). Also pharmaceutical formulations have been surgically implanted into animal tissues where their hardness, insolubility, or other physical properties caused the active compound to be absorbed slowly into the system (Ballard and Nelson, 1962).…”