Absorption of Ferrous and Ferric Radioactive Iron by Human Subjects and by Dogs 1

Moore, Carl V.; Dubach, Reubenia; Minnich, Virginia; Roberts, Harold K.

doi:10.1172/jci101548

Cited by 121 publications

(30 citation statements)

References 10 publications

(15 reference statements)

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“…Calculations have been made suggesting that a braking mechanism exists which prevents the plasma iron from rising above a certain level. 5. Evidence has been presented from radioactive iron studies and observations of the nature of the anemia, that some iron is capable of entering the erythrocytes as hemoglobin in the anemia of chronic infection.…”

Section: Discussionmentioning

confidence: 99%

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The Anemia of Infection. Iv. The Lack of Relationship Between the Diversion of Iron From the Plasma and the Origin of the Anemia 1

Greenberg

Ashenbrucker²,

Lauritsen³

et al. 1947

J. Clin. Invest.

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The pronounced and persistent hypoferremia which accompanies infection, and the rapidity with which intravenously injected iron is removed when given in such cases (1), have led to the suggestion that the anemia of chronic infection results from a local iron deficiency in the bone marrow. Since the quantity of free protoporphyrin in the erythrocytes has been found increased in association with the anemia of infection, the possibility exists that this anemia is the consequence of deficient formation of hemoglobin resulting from a lack of iron. The studies to be described here were designed to test the validity of this hypothesis. Iron was infused continuously in patients with chronic infection in order to determine whether, by raising the iron level to the normal value, synthesis of hemoglobin could be induced. These observations have made it possible to study the rate and degree of diversion of iron from the plasma in infection. Several observations also have been made of the uptake of intravenously administered radioactive iron by the red cells of patients with acute and chronic infections. Evidence will be presented in this communication suggesting that while a rapid removal from the plasma of injected iron occurs in infection, another factor, rather than lack of iron, may be responsible for the development of anemia. METHODSFerrous ascorbate was used for the continuous infusion studies. A 2 per cent aqueous solution was carried through a Seitz filter. With a syringe this was added to a bottle containing 500 ml. sterile 5 per cent glucose solution; thus, the final solution contained 4 mgm. of iron per 100 ml. Since-ferrous ascorbate is a complex with varying amounts of iron (2), each lot had to be analyzed, and the amount used varied accordingly. To obtain quickly the elevated plasma iron level, a single dose of

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Section: Discussionmentioning

confidence: 99%

“…per kgm. body weight (5). A few determinations of hemin Fe have been made according to the technique described in the previous paper (3).…”

Section: Methodsmentioning

confidence: 99%

The Anemia of Infection. Iv. The Lack of Relationship Between the Diversion of Iron From the Plasma and the Origin of the Anemia 1

Greenberg

Ashenbrucker²,

Lauritsen³

et al. 1947

J. Clin. Invest.

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“…Normal dogs fed radioactive iron by Moore et al (19) absorbed greater quantities of iron than reported byHahn, but iron stores in these animals had not been increased by transfusion or by supplementary iron prior to the experiment. Also, the manner in which the iron was administered differed in that Moore gave the iron in solution by stomach tube while Hahn gave the iron mixed in the animals's food.…”

mentioning

confidence: 65%

The Influence of Diet on Iron Absorption

Kinney

Hegsted

Finch

1949

Journal of Experimental Medicine

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Rats placed on a corn grit diet and added iron absorbed large amounts of iron in contrast to control groups. The histological picture was that of progressive hemosiderosis of the hepatic parenchyma and of the reticuloendothelial system. On chemical analysis, the iron content of the liver was found to be greatly increased. This supports the concept that the liver represents the chief storage organ for iron so absorbed. These data indicate that a normal block for iron absorption may be overcome under certain circumstances.

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“…Plasma and serum irons were studied by two methods, that of Moore and his associates (17) in some subjects and that of Barkan and Walker (18) as modified by Grinstein et al (19) in others. Technics used in determining radioactive iron in blood have been described in a previous publication from this laboratory (20). Studies of plasma pH were made with the technic of Cullen (21), adapted to the colorimeter by Evelyn and Malloy (22).…”

Section: Materials Methods and Basic Experi-mental Conditionsmentioning

confidence: 99%

The Role of Oxygen in the Regulation of Erythropoiesis. Depression of the Rate of Delivery of New Red Cells to the Blood by High Concentrations of Inspired Oxygen 12

Tinsley¹,

Moore²,

Dubach³

et al. 1949

J. Clin. Invest.

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Oxygen tension of the environment is regarded as one of the principal regulators of the rate of erythropoiesis. This concept is based largely on the fact that stimulation of red blood cell formation regularly occurs at high altitudes, or under conditions of decreased oxygen tension. Evidence that the converse is true, that high tensions of oxygen can decrease erythrocyte formation, is more fragmentary. A few experiments have demonstrated that animals become anemic within a few weeks when placed in atmospheres containing 60 per cent or more of oxygen at normal barometric pressure (1-3). Early attempts to demonstrate a similar depressant effect in human subjects were unsuccessful, usually because the concentrations of oxygen were not sufficiently high, or because the observations were continued for only short periods of time (4, 5). Since the human red cell normally survives in the circulation for approximately 120 days, it is evident that special technics must be used, or the exposure to high concentrations of oxygen must be continued for weeks if an unequivocal drop in the red blood cell level of a normal subject is to be produced.Reinhard and his associates (6) circumvented these difficulties by using patients with sickle cell anemia as subjects for their studies. Because the survival time of the erythrocyte in sickle cell anemia is short (7,8), and the reticulocyte level is high, it was possible to show that the continuous administration of 80 per cent oxygen by face

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Absorption of Ferrous and Ferric Radioactive Iron by Human Subjects and by Dogs 1

Cited by 121 publications

References 10 publications

The Anemia of Infection. Iv. The Lack of Relationship Between the Diversion of Iron From the Plasma and the Origin of the Anemia 1

The Anemia of Infection. Iv. The Lack of Relationship Between the Diversion of Iron From the Plasma and the Origin of the Anemia 1

The Influence of Diet on Iron Absorption

The Role of Oxygen in the Regulation of Erythropoiesis. Depression of the Rate of Delivery of New Red Cells to the Blood by High Concentrations of Inspired Oxygen 12

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