Absorption of Corticoids and Related Steroids From Subcutaneously Implanted Pellets in the Guinea Pig

Fuenzalida, Florencio; Lipschütz, Alexander

doi:10.1210/jcem-13-10-1201

Cited by 9 publications

(3 citation statements)

References 10 publications

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“…Since data on the relative and absolute absorption rates of the compounds used in these experiments are likely to be useful in the planning of experiments, we have presented them in the following tables. Similar information from tablets implanted in guinea-pigs has recently been published by Fuenzalida [1951] and Fuenzalida & Lipschutz [1953].…”

mentioning

confidence: 57%

“…Dr A. C. Bottomley [see Bishop & Folley, 1952] evolved an equation based on the assumption that the rate of absorption from a fused tablet at any time is proportional to its surface area at that time, and theoretical absorption rates calculated, using this equation, agreed well with those found in practice. In view of this, and the fact that other workers have presented absorption rates of steroid tablets in terms of weight of steroid absorbed per mm2 initial surface area of the tablet [Lipschutz & Vargas, 1941 ;Fuenzalida, 1951;Fuenzalida & Lipschutz, 1953], it appeared to be of interest to compare absorption rates of the steroids implanted as tablets of different size by relating the amount absorbed to the initial surface area of the tablets. In the case of 17-vinyltestosterone (50 and 100 mg tablets) in rats, and DCA (20 and 50 mg tablets) in mice, the relative rates of absorption appeared to be approximately related to the initial surface area of the tablets.…”

Section: Resultsmentioning

confidence: 99%

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The Rate of Absorption of Steroids and Synthetic Oestrogens From Subcutaneously Implanted Tablets

Cowie¹,

Flux²

1954

Journal of Endocrinology

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The rates of absorption of a number of steroid compounds and synthetic oestrogens from subcutaneously implanted tablets in mice, rats and cows are presented and compared with those observed by other workers.The subcutaneous implantation of tablets, a method first investigated by Deanesly & Parkes [1937], provides a convenient way of administering steroid hormones or syn¬ thetic oestrogens to human patients or experimental animals over long periods.Although the rate of absorption of some steroids from tablets has been reported to be variable both in humans [Bishop & Folley, 1952] and in large animals [Malpress, 1952], in a considerable number of experiments, carried out mainly with mice and rats, it was found that similar tablets usually gave similar dose rates when implanted in animals of the same species for the same length of time. Since data on the relative and absolute absorption rates of the compounds used in these experiments are likely to be useful in the planning of experiments, we have presented them in the following tables. Similar information from tablets implanted in guinea-pigs has recently been published by Fuenzalida [1951] and Fuenzalida & Lipschutz [1953]. MATERIALS AND METHODSIn ah cases the tablets were made by the compression of pure steroids or diethylstilboestrol or hexoestrol, no excipient or diluent being used. Except for some of the diethylstilboestrol tablets implanted in cows, all the tablets were made singly in a hand press in the laboratory. The dimensions of specimen tablets of most of the com¬ pounds used and the pressures used in their manufacture are shown in Table 1. Ah tablets of the same weight were made at the same pressure and in the same stocks and dies so that the tablets of any compound used in the experiments but not shown in Table 1 would be very similar in size to those (of the same weight) of compounds which are included.Tablets were implanted subcutaneously, in mice and rats under ether anaesthesia in the region of the shoulders and occasionally in the caudal part of the back, and in cows in the side of the neck under local anaesthesia. The tablets were weighed before implantation and again after removal when they had been cleaned, dried and ahowed to come to a constant weight in air. Except in the case of diethylstilboestrol tablets

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confidence: 57%

Section: Resultsmentioning

confidence: 99%

The Rate of Absorption of Steroids and Synthetic Oestrogens From Subcutaneously Implanted Tablets

Cowie¹,

Flux²

1954

Journal of Endocrinology

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“…In certain experiments pellets were used which contained a mixture of a P-derivative with cholesterol in order to slow down absorp¬ tion. In these experiments absorption was calculated on the assumption of nonselective absorption [for details see Fuenzalida, 1950;Fuenzalida & Lipschutz, 1953]. The methods used for classifying the 'Fibrous Tumoural Effect' were those sum¬ marized by Lipschutz [1950a] and which have been applied in this Institute for the last 17 years.…”

Section: Methodsmentioning

confidence: 99%

COMPARATIVE ANTIOESTROGENIC POTENCIES OF PROGESTERONE AND ESTERIFIED 17α-Hydroxy-Progesterone IN THE GUINEA-PIG

A¹,

Jadrijevic²,

Mardones³

et al. 1957

Journal of Endocrinology

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Five different antioestrogenic activities inherent in progestational compounds such as the antifibromatogenic, antihysterotrophic and antiluteinizing actions, the prevention of the oestrogen\x=req-\ induced opening of the vaginal membrane, and the counteracting of alopecia, have been investigated in the guinea-pig in experiments with 17\g=a\-hydroxyprogesterone and its caproate and acetate.These antioestrogenic properties are either not inherent in the above-mentioned compounds, or only inherent to a slight degree. The very slight antioestrogenic potency of 17 \g=a\-hydroxyprogesterone is not increased by esterification with either caproic or acetic acid.The clinical significance of these findings is discussed.

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Resorption, Verteilung und Ausscheidung der Gestagene

Langecker¹

1968

Die Gestagene

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Absorption of Corticoids and Related Steroids From Subcutaneously Implanted Pellets in the Guinea Pig

Cited by 9 publications

References 10 publications

The Rate of Absorption of Steroids and Synthetic Oestrogens From Subcutaneously Implanted Tablets

The Rate of Absorption of Steroids and Synthetic Oestrogens From Subcutaneously Implanted Tablets

COMPARATIVE ANTIOESTROGENIC POTENCIES OF PROGESTERONE AND ESTERIFIED 17α-Hydroxy-Progesterone IN THE GUINEA-PIG

Resorption, Verteilung und Ausscheidung der Gestagene

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