Absorption of bile acids from the large bowel in man

Samuel, Paul; Saypol, George M.; Meilman, Edward; Mosbach, Erwin H.; Chafizadeh, M

doi:10.1172/jci105892

Cited by 112 publications

(22 citation statements)

References 21 publications

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“…Together with the observation that patients without a colon have little or no secondary bile acids in their bile or ileostomy effluent (Percy-Robb, Brunton, Jalan, McManus, Gould, and Sircus, 1969; unpublished personal obervations), our data suggest that in man the large intestine is a major site of dehydroxylation of bile acids. They also confirm the ability of the colon to absorb bile acids.…”

Section: Stagg (Gastrointestinal and Surgical Units Universitysupporting

confidence: 71%

Proceedings: British Society of Gastroenterology: 31st Annual General Meeting

1970

Gut

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Section: Stagg (Gastrointestinal and Surgical Units Universitysupporting

confidence: 71%

Proceedings: British Society of Gastroenterology: 31st Annual General Meeting

1970

Gut

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“…The daily fecal mass was increased in all patients (Table I (18) and the colon (19), the enterohepatic circulation of bile salts is primarily dependent upon active absorption from the ileum (20)(21)(22). Abnormally rapid fecal elimination of intravenously or orally administered isotopic cholic acid has been demonstrated in laboratory animals after ileal resection or bypass (23) and in man with ileal resection, bypass, or disease (3-5).…”

Section: Resultsmentioning

confidence: 99%

Fecal excretion of bile acids: a new technique for studying bile acid kinetics in patients with ileal resection

Woodbury¹,

Kern²

1971

J. Clin. Invest.

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“…1 and 7). Several lines of evidence suggest a possible role for the colon in the absorption of bile acids in addition to the predominant role of the ileum (25,27,33). In perfused human colon, Mekhjian et al (25) found that several kinds of bile acids such as chenodeoxycholate, deoxycholate, and cholate are also significantly absorbed.…”

Section: Discussionmentioning

confidence: 99%

ATP-dependent transport of organic anions into isolated basolateral membrane vesicles from rat intestine

Shoji

Suzuki

Kusuhara

et al. 2004

American Journal of Physiology-Gastrointestinal and Liver Physi

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. ATP-dependent transport of organic anions into isolated basolateral membrane vesicles from rat intestine. Am J Physiol Gastrointest Liver Physiol 287: G749 -G756, 2004. First published June 24, 2004 10.1152/ ajpgi.00065.2003The mechanism for the cellular extrusion of organic anions across the intestinal basolateral membrane was examined using isolated membrane vesicles from rat jejunum, ileum, and colon. It was found that 17␤-estradiol 17␤-D-glucuronide (E217␤G) is taken up in an ATP-dependent manner into the basolateral membrane vesicles (BLMVs) but not into the brush-border or microsomal counterparts. The ATP-dependent uptake of E217␤G into BLMVs from jejunum and ileum was described by a single component with a Km value of 23.5 and 8.31 M, respectively, whereas that into the BLMVs from colon was described by assuming the presence of high (Km ϭ 0.82 M)-and low-affinity (Km ϭ 35.4 M) components. Taurocholate, 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole glucuronide and taurolithocholate sulfate, but not leukotriene C4, were significantly taken up by the BLMVs. In addition to such substrate specificity, the inhibitor sensitivity of the ATP-dependent transport in BLMVs was similar to that of rat multidrug resistance-associated protein 3 (Mrp3), which is located on the basolateral membrane of enterocytes. Together with the fact that the rank order of the extent of the expression of Mrp3 (jejunum Ͻ ileum ϽϽ colon) is in parallel with that of the extent of the transport of ligands, these results suggest that the ATP-dependent uptake of organic anions into isolated intestinal BLMVs is at least partly mediated by Mrp3.

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Absorption of bile acids from the large bowel in man

Cited by 112 publications

References 21 publications

Proceedings: British Society of Gastroenterology: 31st Annual General Meeting

Proceedings: British Society of Gastroenterology: 31st Annual General Meeting

Fecal excretion of bile acids: a new technique for studying bile acid kinetics in patients with ileal resection

ATP-dependent transport of organic anions into isolated basolateral membrane vesicles from rat intestine

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