Absorption of Anthocyanins from Blueberries and Serum Antioxidant Status in Human Subjects

Mazza, G.; Kay, Colin D.; Cottrell, Tony; Holub, Bruce J.

doi:10.1021/jf020690l

Cited by 414 publications

(301 citation statements)

References 35 publications

Supporting

Mentioning

278

Contrasting

Unclassified

Order By: Relevance

“…When flavanone aglycones (FA) consisting abundantly of eriodictyol were ingested in humans, the difference in absorption characteristics after ingestion of FG or FA was also examined. Flavonoid metabolites in plasma were reported to be detected at an early hour after ingestion of flavonoids in humans (15)(16)(17)(18)(19). We examined the metabolites in plasma up to 4.0 h after ingestion of FG with water and FA with water in humans in this study.…”

mentioning

confidence: 99%

Difference in Plasma Metabolite Concentration after Ingestion of Lemon Flavonoids and Their Aglycones in Humans

Miyake

Sakurai

Usuda

et al. 2006

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

SummaryThe concentrations of metabolites in human plasma after ingestion of flavanone glycosides (FG) and their aglycones (FA) in lemon were examined. FG consisting abundantly of eriocitrin were prepared from lemon peel and FA consisting abundantly of eriodictyol were prepared from FG by treatment with ␤-glucosidase. Eriodictyol, homoeriodictyol, and hesperetin in plasma up to 4 h after ingestion of FG with water or FA with water by subjects were not detected in plasma of non-enzyme treatment but in plasma after treatment with ␤-glucronidase and sulfatase. Metabolites in plasma after ingestion of FG and FA in humans were shown to exist as the glucuro-and/or sulfo-conjugates of eriodictyol, homoeriodictyol, and hesperetin. After ingestion of FA, the concentration of metabolites in plasma exhibited a high maximum peak at 1 h. The AUC (area under the blood concentration time curve) level of metabolites of FA was higher than that of FG. FA were suggested to be absorbed faster and in higher amounts than FG. The AUC of metabolites in subject plasma after ingestion of FG with flavonoid-depleted lemon juice was shown to change to a low level in comparison with that of FG with water. The maximum concentration peak of metabolites in plasma was faster at 0.5 h than FA with water but the AUC level was similar to FA with water, when subjects ingested FA with vodka (40% ethanol). The absorption hour of FG and FA was shown to be affected by the co-existing solution. Key Words lemon flavonoid, eriocitrin, plasma, human, ingestion Epidemiological studies indicate a protective relationship between the consumption of citrus fruits or juice and the risk of ischemic stroke and lung cancer (1, 2). Some fundamental studies support a protective effect provided by flavonoid consumption in these diseases (3-6). Citrus fruits contain various kinds of flavonoids such as flavanone glycoside, flavone glycoside, and polymethoxyflavone (3, 4). Flavonoids in lemon fruit (Citrus limon BURM. f.) have been reported to be such flavanone glycosides as eriocitrin (eriodictyol 7-O-␤-rutinoside) and hesperidin (hesperetin 7-O-␤-rutinoside) and such flavone glycosides as diosmin (diosmetin 7-O-␤-rutinoside) and 6,8 C-diglucosyldiosmetin (7-10). Eriocitrin has been reported to be the most abundant flavonoid in lemon fruit and to have the highest antioxidative activity of the flavonoids in citrus fruits in vitro (9,11). It was also shown to have a suppressive effect for oxidative stress in the liver of streptozotocin-induced diabetic rats (12) or exercise-induced rats (13).For the study of functional compounds such as flavonoids in foods, it is important to determine how the compounds in food are metabolized and absorbed in vivo and how the metabolites function in a living system. There have been several human studies that have investigated the metabolism and absorption of flavonoids (14), such as anthocyanin (15, 16), flavonol (17, 18), isoflavone (19), and flavanone (20-22). As for eriocitrin, it was reported for metabolites by human intestinal bacteri...

show abstract

mentioning

confidence: 99%

Difference in Plasma Metabolite Concentration after Ingestion of Lemon Flavonoids and Their Aglycones in Humans

Miyake

Sakurai

Usuda

et al. 2006

J Nutr Sci Vitaminol

View full text Add to dashboard Cite

show abstract

“…Depending on nutritional custom, the daily intake of these compounds in humans is estimated to be a few hundred milligrams per day [Hollman and Katan, 1999]. They are absorbed by stomach [Passamonti et al, 2003] and intestinal cells [Talavera et al, 2004] and are rapidly detected in plasma in vivo [Mazza et al, 2002] suggesting that they are bioavailable to exert their biological effects. Consumption of anthocyanins has been shown to reduce the risk of coronary heart disease [Dell'Agli et al, 2004] and cancer [Hou, 2003].…”

mentioning

confidence: 99%

Anthocyanidins inhibit migration of glioblastoma cells: Structure‐activity relationship and involvement of the plasminolytic system

Lamy

Lafleur

Bédard

et al. 2006

J of Cellular Biochemistry

View full text Add to dashboard Cite

Complete resection of malignant glioblastomas is usually impossible because of diffuse and widespread invasion of tumor cells, and complementary approaches need to be developed in order to improve the efficacy of current treatments. Consumption of fruits and berries has been associated with decreased risk of developing cancer and there is great interest in the use of molecules from dietary origin to improve anticancer therapies. In this work, we report that the aglycons of the most abundant anthocyanins in fruits, cyanidin (Cy), delphinidin (Dp), and petunidin (Pt), act as potent inhibitors of glioblastoma cell migration. Dp clearly exhibited the highest inhibitory potency, this effect being related to the ortho-dihydroxyphenyl structure on the B-ring and the presence of a free hydroxyl group at position 3. Dp decreases the expression of both urokinase-type plasminogen activator receptor (uPAR) and the low-density lipoprotein receptor-related protein (LRP), acting at the transcriptional levels. In addition, Dp upregulated urokinase-type plasminogen activator (uPA) and downregulated the plasminogen activator inhibitor-1 (PAI-1) but decreased, in a concentration-dependent manner, the uPA-dependent conversion of plasminogen to plasmin, indicating that the upregulation of uPA observed with these compounds was not associated with induction of the plasminolytic activity. Overall, these results demonstrate that Dp, Pt, and Cy affect plasminogen activation, thus leading to the inhibition of glioblastoma cell migration and therefore they may be helpful for the development of new strategies for cancer prevention and therapy.

show abstract

“…In addition, these compounds also correlate with better performance of the enzymes of the endogenous antioxidant system 24 . Bioavailability studies found that anthocyanins and their metabolites are largely present in the liver, being associated with high hepatic antioxidant capacity 25 . Thus, the addition of 2% freeze-dried jaboticaba peel to the high-fat diet might have protected the liver from obesity-induced oxidative stress by providing exogenous and endogenous antioxidants, preventing lipid oxidation 24 .…”

Section: Discussionmentioning

confidence: 99%

Jaboticaba (Myrciaria jaboticaba (Vell.) Berg.) peel improved triglycerides excretion and hepatic lipid peroxidation in high-fat-fed rats

Batista

Lenquiste

Moldenhauer³

et al. 2013

Rev. Nutr.

View full text Add to dashboard Cite

ERRATANo artigo "Jaboticaba (Myrciaria jaboticaba (Vell.) Berg.) peel improved triglycerides excretion and hepatic lipid peroxidation in high-fat-fed rats" publicado no número 5, volume 26, Revista de Nutrição, na página 571, onde se lê:"Jaboticaba (Myrciaria jaboticaba (Vell.) Berg.) peel increased triglycerides excretion and hepatic lipid peroxidation in high-fat-fed rats" Leia-se:"Jaboticaba (Myrciaria jaboticaba (Vell.) Berg.) peel improved triglycerides excretion and hepatic lipid peroxidation in high-fat-fed rats"No mesmo artigo, na página 577, onde de lê:"As unidades na Figura 2 (C, D, E, F) de g 100g -1 " Leia-se:"As unidades na Figura 2 (C, D, E, F) mg 100g -1 "

show abstract

Absorption of Anthocyanins from Blueberries and Serum Antioxidant Status in Human Subjects

Cited by 414 publications

References 35 publications

Difference in Plasma Metabolite Concentration after Ingestion of Lemon Flavonoids and Their Aglycones in Humans

Difference in Plasma Metabolite Concentration after Ingestion of Lemon Flavonoids and Their Aglycones in Humans

Anthocyanidins inhibit migration of glioblastoma cells: Structure‐activity relationship and involvement of the plasminolytic system

Jaboticaba (Myrciaria jaboticaba (Vell.) Berg.) peel improved triglycerides excretion and hepatic lipid peroxidation in high-fat-fed rats

Contact Info

Product

Resources

About