Absorption enhancing agents for the GI system

Combinatorial Use of Sodium Laurate with Taurine or L‐Glutamine Enhances Colonic Absorption of Rebamipide, Poorly Absorbable Antiulcer Drug, without Any Serious Histopathological Mucosal Damages

“…This problem must be overcome to develop a new drug having better pharmacological activity. As the improvement of drug solubility or permeability by using an absorption enhancer has been very attractive from the aspects of biopharmaceutics, pharmacology, and economics, many researchers investigated the absorption enhancement using various adjuvants 1–5. However, it has been very difficult to use those adjuvants for practical formulation, because they possibly cause the local toxicity 2.…”

Mechanisms of cytoprotective effect of amino acids on local toxicity caused by sodium laurate, a drug absorption enhancer, in intestinal epithelium

“…The improvement of drug bioavailability by use of an absorption enhancer has been a very attractive concept in the areas of biopharmaceutics, pharmacology, toxicology, and economics. Many researchers, therefore, have tried to determine the compounds with this absorption‐promoting activity 1–5. However, the potential local toxicity of the enhancers themselves has made it difficult to apply them to the practical use 2.…”

Amino Acids Protect Epithelial Cells From Local Toxicity by Absorption Enhancer, Sodium Laurate

“…The improvement of bioavailability by using an absorption enhancer, therefore, has been a very attractive concept. Numerous compounds have been reported to have absorption‐promoting activity1–9 and many researchers have tried to elucidate the mechanisms by which the absorption can be enhanced 4,8,10–13. However, the potential local toxicity of the enhancers themselves has made it difficult to apply them to practical use 4.…”