Absorption, Distribution, Metabolism, and Excretion of Biopharmaceutical Drug Products

Graveno, Molly; Stratford, Robert E.

doi:10.1007/978-3-319-99593-9_11

Cited by 1 publication

(1 citation statement)

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“…This publication explores drug bioavailability, a crucial indicator of pharmacological therapy efficacy. It explains basic concepts and measures, including the release, absorption, distribution, metabolism, and elimination of drugs [11]. Factors affecting bioavailability include physicochemical, biological, pharmaceutical, and patient-related aspects.…”

Section: Introductionmentioning

confidence: 99%

The Bioavailability of Drugs—The Current State of Knowledge

Stielow,

Witczyńska,

Kubryń

et al. 2023

Molecules

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Drug bioavailability is a crucial aspect of pharmacology, affecting the effectiveness of drug therapy. Understanding how drugs are absorbed, distributed, metabolized, and eliminated in patients’ bodies is essential to ensure proper and safe treatment. This publication aims to highlight the relevance of drug bioavailability research and its importance in therapy. In addition to biochemical activity, bioavailability also plays a critical role in achieving the desired therapeutic effects. This may seem obvious, but it is worth noting that a drug can only produce the expected effect if the proper level of concentration can be achieved at the desired point in a patient’s body. Given the differences between patients, drug dosages, and administration forms, understanding and controlling bioavailability has become a priority in pharmacology. This publication discusses the basic concepts of bioavailability and the factors affecting it. We also looked at various methods of assessing bioavailability, both in the laboratory and in the clinic. Notably, the introduction of new technologies and tools in this field is vital to achieve advances in drug bioavailability research. This publication also discusses cases of drugs with poorly described bioavailability, providing a deeper understanding of the complex challenges they pose to medical researchers and practitioners. Simultaneously, the article focuses on the perspectives and trends that may shape the future of research regarding bioavailability, which is crucial to the development of modern pharmacology and drug therapy. In this context, the publication offers an essential, meaningful contribution toward understanding and highlighting bioavailability’s role in reliable patient treatment. The text also identifies areas that require further research and exploration.

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Section: Introductionmentioning

confidence: 99%