Absorption, Distribution and Elimination of Labeled Dimethyl Sulfoxide in Man and Animals

Kolb, K H; Jaenicke, G.; Kramer, Michael; Schulze, P. E.

doi:10.1111/j.1749-6632.1967.tb34869.x

Cited by 107 publications

(31 citation statements)

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“…The industrial solvent dimethylsulphox ide (DMSO) was found to be therapeutically beneficial when applied to skin as an analgesic and anti-inflammatory agent by re ducing the swelling and pain of sprains and arthritis [4], Subsequently, it has been shown to readily penetrate skin [6] and to facilitate transport of other drugs through skin for absorption in the blood [5]. DMSO also acts as a diuretic and possesses antibacterial [11], antiviral [10], cryptoprotective [12] and antisclerotic properties [2].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Dimethylsulphoxide in Stress- and Indometacin-Induced Gastrointestinal Ulceration in Rats

Ali

1989

Pharmacology

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The protective effect of dimethylsulphoxide (DMSO) against stress- and indo-metacin-induced gastrointestinal ulcers was assessed in rats. It was found that stress (restraint at 4 ° C for 3 h) produced mucosal lesions in the stomach antrum and corpus, and the small intestine. DMSO given in the drinking water at concentrations of 1 2, 4 or 6 % (v/v) 7 days before the application of stress produced dose-dependent decreases in both the number of ulcers and the ulcer index (UI). These decreases were significant at doses of 4 and 6% (v/v). Indometacin was effective in producing ulcers in the gastric antrum and small intestine, but not in the corpus of the stomach, when it was given to rats fasted for 24 h and fed for 1 h before drug administration. Again, pretreatment with DMSO, at doses of 4 and 6% (v/v) for 7 days was effective in reducing significantly the number of ulcers and the UI in the indo-metacin-treated rats. At all doses of DMSO there were no significant changes in the haemogram or in the histological (light microscopic) picture of the organs examined. A small reduction (6%) in the body weight was observed in rats on the higher dose of DMSO, probably due to decreased feed intake (10%) in this group. Further pharmacological and toxicological studies on DMSO seem warranted.

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Section: Introductionmentioning

confidence: 99%

Protective Effect of Dimethylsulphoxide in Stress- and Indometacin-Induced Gastrointestinal Ulceration in Rats

Ali

1989

Pharmacology

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“…A wide range of primary pharmacological actions of DMSO has been documented in laboratory studies: membrane transport, effects on connective tissue, anti-inflammatory effect, nerve blockade (analgesia), bacteriostasis, diuresis, enhancements or reduction of the effectiveness of other drugs, cholinesterase inhibition, nonspecific enhancement of resistance to infection, vasodilatation, muscle relaxation, antagonism to platelet aggregation, and influence on serum cholesterol in experimental hypercholesterolemia, a scavenger of the free radicals that gather at the site of injury (http://www.dmso.org). Especially, it is interesting that DMSO readily crosses most tissue membranes of lower animals and man [40]. On the basis of our in vitro experimental data, it could be reasonable to investigate DMSO as a carrier of the tungsten compounds as antidiabetic drugs in vivo.…”

Section: Discussionmentioning

confidence: 98%

Insulin Mimetic Effect of Tungsten Compounds on Isolated Rat Adipocytes

Topić

Milenković

Uskoković‐Marković

et al. 2009

Biol Trace Elem Res

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Investigations of effective, orally active, and safe antidiabetic metallopharmaceuticals have been carried out during the last two decades. It has been reported that tungsten compounds mimic the action of insulin in intact cell systems. As insulin mimetics, the most investigated tungsten compound was sodium tungstate (ST), rarely investigated was tungstophosphoric acid (WPA), but never alanine complex of tungstophosphoric acid (WPA-A). In this study, the insulin mimetic activity of three different tungsten compounds, ST, WPA, and WPA-A, was evaluated by means of in vitro measurements of the glucose uptake and inhibition of free fatty acids release from epinephrine-treated isolated rat white adipocytes. We investigated the influence of concentration (lower and higher, 0.1 and 1.0 mM, respectively) and solvent: isotonic salt solution-saline (0.9% w/v of NaCl) and dimethyl sulfoxide (DMSO; 2% v/v), on the biological effect of tested compounds. Our experimental data showed that all of the three investigated tungsten compounds possess insulin mimetic activity in vitro on the isolated adipocytes. Influence of concentration and solvents on insulin mimetic effect for the certain tungsten compounds were: WPA was shown effect independently of concentration and solvents; higher concentration and DMSO were significant decreasing insulin mimetic effect of ST; lower concentration and saline led to decreasing effect of WPA-A. Generally, there were no differences in insulin mimetic effect of three tungsten compounds in lower concentration and dissolved in DMSO. When saline was used as solvent, it was needed higher concentration of investigated compounds to accomplish the same effect. In conclusion, our results suggest that low concentration (0.1 mM) of ST, WPA, and WPA-A dissolved in 2% DMSO could be the good candidates for in vivo investigation of their antidiabetic properties.

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“…The first quality that struck Dr. Jacob about the DMSO drug was its ability to pass through membranes, an ability that has been verified by numerous subsequent researchers [1]. DMSO perhaps has been used most widely as a topical analgesic, in a 70 percent DMSO, 30 percent water solution.…”

Section: Introductionmentioning

confidence: 98%

Effect of Maxima Suppressor and Supporting Electrolyte on Polarographic Wave of Dimethyl Sulfoxide and its Determination

Gupta¹

2016

Med chem

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The oxidation of the biologically very important dimethyl sulfoxide system has been the subject of investigations. In present study Dimethyl sulfoxide (DMSO) can be oxidized to dimethyl sulfone by anodic electrolysis at a rotating platinum electrode. The polarographic method has been used to study qualitatively the effect of maxima suppressor gelatin, fuchsin, methyl red, thymol blue and supporting electrolyte HCl, CH 3 COOH on oxidation wave of DMSO. Polarographic oxidation of DMSO in 0.1 M HCl, 0.1 M CH 3 COOH solution using optimum concentration of fuchsin, methyl red, thymol blue as surface active substances is followed to determine the DMSO present in synthetic sample by calibration method. Wave analysis indicate the irreversible nature of the oxidation process which involves oxidation of dimethyl sulfoxide to dimethyl sulfone thereby increasing the oxidation state of sulphur from +2 to +4 state.

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Absorption, Distribution and Elimination of Labeled Dimethyl Sulfoxide in Man and Animals

Cited by 107 publications

References 0 publications

Protective Effect of Dimethylsulphoxide in Stress- and Indometacin-Induced Gastrointestinal Ulceration in Rats

Protective Effect of Dimethylsulphoxide in Stress- and Indometacin-Induced Gastrointestinal Ulceration in Rats

Insulin Mimetic Effect of Tungsten Compounds on Isolated Rat Adipocytes

Effect of Maxima Suppressor and Supporting Electrolyte on Polarographic Wave of Dimethyl Sulfoxide and its Determination

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