Absorption and Lymphatic Transport of Interesterified or Mixed Fats Rich in Saturated Fatty Acids and Their Effect on Tissue Lipids in Rats

Sakono, Masafumi; Takagi, Hideo D.; Sonoki, Hirofumi; Yoshida, Hiroko; Iwamoto, Masako; Ikeda, Ikuo; Imaizumi, Kazunori

doi:10.1016/s0271-5317(97)00084-5

Cited by 7 publications

(4 citation statements)

References 19 publications

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“…A decrease in liver and plasma concentrations of TAG in response to HSO supplementation has been seen in a rat study (5). This behavior is consistent with the fact that liver stores of TAG are mobilized rapidly when TAG absorption is reduced; they become depleted in parallel with the circulating pool (19)(20)(21)(22). In our study, liver and plasma TAG concentrations and vitamin E concentrations of plasma, LDL and adipose tissue responded in a parallel manner to an addition of HSO to the basal diet.…”

Section: Discussionsupporting

confidence: 66%

Dietary Hydrogenated Soybean Oil Affects Lipid and Vitamin E Metabolism in Rats

Nazıroğlu

Brandsch

2006

J Nutr Sci Vitaminol

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Summary Fatty acids containing stearic acid, which are found in hydrogenated fat, may have a detrimental effect on the cholesterol and triacylglycerol (TAG) content of plasma lipoproteins, and on the absorption of fatty acids and fat-soluble vitamins. The aim of our study was to examine the tissue concentration of lipids and vitamins A and E after feeding a hydrogenated soybean oil (HSO) diet to rats. Twenty male Sprague-Dawley rats were randomly divided into two groups, fed on coconut oil (control) and HSO, respectively in amounts corresponding to 15% of the total feed. Plasma total cholesterol, VLDL-and LDLcholesterol, lipid peroxidation and daily excretion of the TAG and cholesterol in feces were higher in the HSO than in the control group. TAG values in plasma and liver, and HDL-cholesterol levels in plasma were lower in the HSO than in the control group. The same was true for phospholipids in plasma and for saturated fatty acids, mono-and polyunsaturated fatty acids levels in the liver and vitamin E in plasma, LDL and adipose tissue. The results of this study provide new evidence concerning the effect of dietary hydrogenated fat on lipid, TAG and vitamin E status, which are important for maintenance of good health. Consumption of dietary HSO may be associated with cardiovascular disease.

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Section: Discussionsupporting

confidence: 66%

Dietary Hydrogenated Soybean Oil Affects Lipid and Vitamin E Metabolism in Rats

Nazıroğlu

Brandsch

2006

J Nutr Sci Vitaminol

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“…Fat produced by transesterification of coconut oil and palm olein together was better absorbed in rats than a blend of coconut oil and transesterified palm oil (Lien et al, 1993). Calculated from the fecal fat losses, transesterification of tripalmitin and tristearin with vegetable oils increased the absorption of saturated fatty acids compared with the blended fats (Sakono et al, 1997).…”

Section: Saturated Fatty Acids-effects On Digestion and Absorptionmentioning

confidence: 96%

Triacylglycerol Fatty Acid Positional Distribution and Postprandial Lipid Metabolism

Linderborg

Kallio

2005

Food Reviews International

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FinlandTriacylglycerol (TAG) structure affects the biochemical properties of fat. According to studies with animals and infants, absorption of palmitic and stearic acids is inferior from the stereospecifically numbered (sn) positions sn-1 and sn-3 compared with from the sn-2 position of TAGs, and saturated fatty acids in the sn-2 position, delay the clearance of chylomicron remnants. Medium chain fatty acids are transported both in lymph and in portal blood, lymphatic absorption being more efficient from the sn-2 position.Recently, new information has arisen on the variation in TAG composition within the postprandial period and on differences in the TAG structure-dependent formation and clearance of chylomicron and very low density lipoprotein TAGs. This article reviews the metabolism of TAG fatty acids in different sn positions.

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“…However, an obvious problem with the use of MCT is the lack of the essential fatty acids (9,10), and a high dose of MCT also has caused certain toxic effects in the animal experiments (11). Therefore, alternative triacylglycerols have been used in absorption studies, such as physical blends of MCT and LCT, interesterified lipids with random triacylglycerol structure or specific triacylglycerol structure (12)(13)(14)(15)(16)(17)(18).…”

mentioning

confidence: 99%

Effects of different medium‐chain fatty acids on intestinal absorption of structured triacylglycerols

Høy

2000

Lipids

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To study the effect of the chain length of medium-chain fatty acids on the intestinal absorption of long-chain fatty acids, we examined the lymphatic transport of fat following administration of five purified structured triacylglycerols (STAG) containing different medium-chain fatty acids in the sn-1,3 positions and long-chain fatty acids in the sn-2 position in a rat model. Significant amounts of medium-chain fatty acids were found in lymph samples after intragastric administration of 1,3-dioctanoyl-2-linoleyl-sn-glycerol (8:0/18:2/8:0), 1,3-didecanoyl-2-linoleyl-sn-glycerol, and 1,3-didodecanoyl-2-linoleyl-sn-glycerol. The accumulated lymphatic transport of medium-chain fatty acids increased with increasing carbon chain length. The recoveries of caprylic acid (8:0), capric acid (10:0), and lauric acid (12:0) were 7.3 +/- 0.9, 26.3 +/- 2.4, and 81.7 +/- 6.9%, respectively. No significant differences were observed for the maximal intestinal absorption of linoleic acid (18:2n-6) when the chain length of medium-chain fatty acids at the primary positions was varied, and the absorption of 18:2 and oleic acid (18:1) from 8:0/18:2/8:0 and 1,3-dioctanoyl-2-oleyl-sn-glycerol was similar. We conclude that the chain length of the medium-chain fatty acids in the primary positions of STAG does not affect the maximal intestinal absorption of long-chain fatty acids in the sn-2 position in the applied rat model, whereas the distribution of fatty acids between the lymphatics and the portal vein reflects the chain length of the fatty acids.

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Absorption and Lymphatic Transport of Interesterified or Mixed Fats Rich in Saturated Fatty Acids and Their Effect on Tissue Lipids in Rats

Cited by 7 publications

References 19 publications

Dietary Hydrogenated Soybean Oil Affects Lipid and Vitamin E Metabolism in Rats

Dietary Hydrogenated Soybean Oil Affects Lipid and Vitamin E Metabolism in Rats

Triacylglycerol Fatty Acid Positional Distribution and Postprandial Lipid Metabolism

Effects of different medium‐chain fatty acids on intestinal absorption of structured triacylglycerols

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