Absorption and Excretion of Tranexamic Acid following Intravenous, Intramuscular and Oral Administrations in Healthy Volunteers

Tranexamic Acid Reduces Blood Loss and Blood Transfusion after TKA: A Prospective Randomized Controlled Trial

“…These authors also thought hemostatic control was better when tranexamic acid was administered before surgery rather than on deflation of the tourniquet and suggested suppression of fibrinolysis from the beginning of the operation may be more effective than only later at the time of peak hyperfibrinolysis [53]. Pharmacokinetic studies [5,13,49,57] indicate a dose of 20 mg/kg tranexamic acid is suitable for TKA. A therapeutic level can be maintained for approximately 8 hours after surgery, and this covers the period of hyperfibrinolysis in cases of increased blood loss [25].…”

“…There are four methods of administering tranexamic acid to reduce blood loss in TKA: intramuscular, oral, intravenous, and intraarticular [53]. The time taken for maximum plasma levels of tranexamic acid to be reached is reportedly 30 minutes for intramuscular, 2 hours for oral, and 5 to 15 minutes for intravenous administration [5,49]. An intravenous injection for patients undergoing TKA is the best method for rapidly increasing and maintaining the therapeutic concentration of tranexamic acid.…”

Ácido tranexámico endovenoso en el reemplazo total de rodilla sin manguito hemostático. Intravenous­ tranexamic ­acid­ in­ total ­knee­ arthroplasty­ without­ tourniquet

“…Se puede administrar por vía endovenosa, intramuscular, oral y tó-pica. 7,11,12,16,[20][21][22] La vía endovenosa alcanza los máximos valores en sangre entre los 5 y 15 minutos. 9,22 Ahlberg reportó que la difusión a la membrana sinovial del áci-do tranexámico administrado por vía endovenosa ocurre rápidamente, por lo que no hay razón para su aplicación tópica.…”

“…7,11,12,16,[20][21][22] La vía endovenosa alcanza los máximos valores en sangre entre los 5 y 15 minutos. 9,22 Ahlberg reportó que la difusión a la membrana sinovial del áci-do tranexámico administrado por vía endovenosa ocurre rápidamente, por lo que no hay razón para su aplicación tópica. 23 Algunos autores han informado que el ácido tranexámico disminuye la pérdida de sangre y los requerimientos transfusionales con una dosis al momento de liberar el manguito y otra durante el posoperatorio.…”

Is Intraarticular Administration of Tranexamic Acid Better than Its Intravenous Administration in Reducing Blood loss after total Knee Arthroplasty?

“…[9], [14] In our study we open the suction drain tube after an hour of application and still have managed excellent results, still proving that this 1 hour is the most important time for action of this drug"(TXA).The maximum plasma concentration is achieved in 30 min after intramuscular administration. [24], [25] Also the half-life of the drug is less than 3 hour, [2], [3], [10] and therefore there is a accelerateddecrease in plasma levels of this drug. Therefore, the plasma values that Wong et al, have measured might be misleading.…”