Absorption and disposition kinetics of the dietary antioxidant quercetin in man

Hollman, P.C.H.; Gaag, Martijn van der; Mengelers, Marcel; Trijp, J.M.P. van; Vries, J.H.M. de; Katan, Martijn B.

doi:10.1016/0891-5849(96)00129-3

Cited by 364 publications

(193 citation statements)

References 19 publications

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“…Several studies have provided information on the bioavailability of¯avonoids from a food matrix, however they give no indication of the potential antioxidant activity associated with this absorption (Hollman et al, , 1996b(Hollman et al, , 1997aAziz et al, 1998). We have therefore examined the effects of long-term rutin (quercetin-3-O-brutinoside) supplementation in human volunteers.…”

Section: Discussionmentioning

confidence: 99%

Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study

Boyle¹,

Dobson²,

Duthie³

et al. 2000

Eur J Clin Nutr

175

107

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Objective: To determine the potential antioxidant effect of rutin (quercetin-3-O-b-rutinoside) supplementation. Design: A 6-week randomized single-blind placebo controlled trial was conducted; 500 mg rutin supplement was compared to an equivalent amount of glucose placebo. In addition, a pharmacokinetic study was carried out. Setting: The Rowett Research Institute, Aberdeen, UK. Subjects: Eighteen healthy non-obese normocholesterolaemic female volunteers in the age range 18 ± 48 y. Main outcome measures: Plasma¯avonoids, ascorbic acid, tocopherols and carotenoids, plasma antioxidant capacity, lymphocyte DNA damage, blood chemistry and haematology, liver function tests, urinary malondialdehyde, 8-hydroxy-2H -deoxyguanosine and 8-iso-prostaglandin F 2a . Results: Eighteen volunteers completed the trial. Rutin supplementation did not induce any adverse changes in blood chemistry or indices of liver function. Plasma¯avonoids were signi®cantly elevated in the rutinsupplemented group. Endogenous oxidation of pyrimidines was signi®cantly decreased in both rutin-and placebo-treated volunteers. There was no signi®cant change in the level of urinary 8-hydroxy-2 H -deoxyguanosine or urinary malondialdehyde in either group. A linear correlation was observed between urinary malondialdehyde and urinary 8-iso-prostaglandin F 2a (R 0.54, P`0.01). Conclusion: Six weeks' rutin supplementation signi®cantly elevated the levels of three plasma¯avonoids (quercetin, kaempferol and isorhamnetin) but there was no signi®cant change in plasma antioxidant status. The decrease in the level of endogenous base oxidation in lymphocyte DNA seen in both the placebo-and rutinsupplemented subjects may re¯ect seasonal changes in other dietary antioxidants.

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Section: Discussionmentioning

confidence: 99%

Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study

Boyle¹,

Dobson²,

Duthie³

et al. 2000

Eur J Clin Nutr

175

107

View full text Add to dashboard Cite

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“…For example, it was estimated that the daily consumption of flavonols plus flavones is 3-80 mg. 24,25) Moreover, the papers that the ingestion of 64 mg quercetin resulted 3 h later in a concentration of 650 nM quercetin in hydrolyzed plasma was reported. 25,26) Another study performed in 10 healthy volunteers showed that ingested quercetin 87 mg resulted in a quercetin concentration in hydrolyzed plasma ranging from 129-843 nM after 3 h. 25) Taking into account the average intake of flavonoids in general and their absorption amount, it is suggested that they might act as antagonists of AhR in usual intake.…”

Section: Resultsmentioning

confidence: 99%

Screening of the Inhibitory Effect of Vegetable Constituents on the Aryl Hydrocarbon Receptor-Mediated Activity Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Amakura

Tsutsumi

Sasaki

et al. 2003

Biological & Pharmaceutical Bulletin

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“…Table 1 shows the time to reach the maximum catechin concentration and the elimination rate, based on a one compartment model. For green tea, the peak concentration of catechins in blood was reached on average 2.3 h after ingestion and the mean elimination half-life was 4.8 h. Hollman et al (1996) have reported the kinetics of the plasma response of the¯avonol quercetin following consumption of a single portion of onions. They found, based on two subjects, that the maximum plasma response was reached after 3.3 h and that the elimination half-life was 16.8 h. Apparently, there are substantial differences in kinetics of uptake and elimination of different¯avonoids.…”

Section: Bioavailability Of Catechins From Tea Kh Van Het Hof Et Almentioning

confidence: 99%

Bioavailability of catechins from tea: the effect of milk

et al. 1998

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Objectives: To assess the blood concentration of catechins following green or black tea ingestion and the effect of addition of milk to black tea. Design: Twelve volunteers received a single dose of green tea, black tea and black tea with milk in a randomized cross-over design with one-week intervals. Blood samples were drawn before and up to eight hours after tea consumption. Setting: The study was performed at the Unilever Research Vlaardingen in The Netherlands. Subjects: Twelve healthy adult volunteers (7 females, 5 males) participated in the study. They were recruited among employees of Unilever Research Vlaardingen. Interventions: Green tea, black tea and black tea with semi-skimmed milk (3 g tea solids each). Results: Consumption of green tea (0.9 g total catechins) or black tea (0.3 g total catechins) resulted in a rapid increase of catechin levels in blood with an average maximum change from baseline (CVM) of 0.46 mmol/l (13%) after ingestion of green tea and 0.10 mmol/l (13%) in case of black tea. These maximum changes were reached after (mean (s.e.m.)) t 2.3 h (0.2) and t 2.2 h (0.2) for green and black tea respectively. Blood levels rapidly declined with an elimination rate (mean (CVM)) of t 1a2 4.8 h (5%) for green tea and t 1a2 6.9 h (8%) for black tea. Addition of milk to black tea (100 ml in 600 ml) did not signi®cantly affect the blood catechin levels (areas under the curves (mean (CVM) of 0.53 h. mmol/l (11%) vs 0.60 h. mmol/l (9%) for black tea and black tea with milk respectively. Conclusion: Catechins from green tea and black tea are rapidly absorbed and milk does not impair the bioavailability of tea catechins.

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Absorption and disposition kinetics of the dietary antioxidant quercetin in man

Cited by 364 publications

References 19 publications

Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study

Bioavailability and efficiency of rutin as an antioxidant: a human supplementation study

Screening of the Inhibitory Effect of Vegetable Constituents on the Aryl Hydrocarbon Receptor-Mediated Activity Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Bioavailability of catechins from tea: the effect of milk

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