Absorbent Dressings

Vachhrajani, Vibhakar; Khakhkhar, Payal

doi:10.1007/978-981-32-9236-9_5

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Hydrogel-based dressings cover the injury site, absorb the blood and exudate and provide physical support during the wound-healing process [ 1 ]. The ideal wound dressing should not only absorb excess exudate but also create a moist wound-healing environment, be mechanically strong and be easily removed [ 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Electron-Beam-Initiated Crosslinking of Methacrylated Alginate and Diacrylated Poly(ethylene glycol) Hydrogels

Mignon,

Zimmer,

Gutierrez Cisneros

et al. 2023

Polymers

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An ideal wound dressing not only needs to absorb excess exudate but should also allow for a moist wound-healing environment as well as being mechanically strong. Such a dressing can be achieved by combining both a natural (alginate) and synthetic (poly(ethylene glycol) polymer. Interestingly, using an electron beam on (meth)acrylated polymers allows their covalent crosslinking without the use of toxic photo-initiators. The goal of this work was to crosslink alginate at different methacrylation degrees (26.1 and 53.5% of the repeating units) with diacrylated poly(ethylene glycol) (PEGDA) using electron-beam irradiation at different doses to create strong, transparent hydrogels. Infrared spectroscopy showed that both polymers were homogeneously distributed within the irradiated hydrogel. Rheology showed that the addition of PEGDA into alginate with a high degree of methacrylation and a polymer concentration of 6 wt/v% improved the storage modulus up to 15,867 ± 1102 Pa. Gel fractions > 90% and swelling ratios ranging from 10 to 250 times its own weight were obtained. It was observed that the higher the storage modulus, the more limited the swelling ratio due to a more crosslinked network. Finally, all species were highly transparent, with transmittance values > 80%. This may be beneficial for the visual inspection of healing progression. Furthermore, these polymers may eventually be used as carriers of photosensitizers, which is favorable in applications such as photodynamic therapy.

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Section: Introductionmentioning

confidence: 99%

Electron-Beam-Initiated Crosslinking of Methacrylated Alginate and Diacrylated Poly(ethylene glycol) Hydrogels

Mignon,

Zimmer,

Gutierrez Cisneros

et al. 2023

Polymers

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Gelatin‐Based Versus Alginate‐Based Hydrogels: Providing Insight in Wound Healing Potential

Ionescu

Mignon

Minsart

et al. 2021

Macromolecular Bioscience

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Wound dressings under the form of films constituted of modified alginate (methacrylated alginate – AlgMA) versus a gelatine derivative containing norbornene functionalities (GelNB) are developed and evaluated for their moisturizing effects, followed by further in vivo testing to assay their wound healing potential. The gel fraction results shows that AlgMA and GelNB films displayed a high crosslinking efficiency while the swelling assay reveals a stronger water uptake capacity for AlgMA films compared to GelNB and to commercial dressing AquacelAg, used as positive control. Referring to the in vivo wound healing effect, the GelNB films not only exhibit proper healing properties, yet is higher to the AquacelAg, while the AlgMA films exhibit similar wound healing effect as the positive control. On a microscopic level, the healing phases (from inflammation to proliferation and contraction) are present for both materials, yet at a faster rate for the GelNB films, which is in line with the macroscopic findings. These results provide data which support that GelNB films outperform AlgMA films, but both can be used for wound healing applications.

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Absorbent Dressings

Cited by 2 publications

References 10 publications

Electron-Beam-Initiated Crosslinking of Methacrylated Alginate and Diacrylated Poly(ethylene glycol) Hydrogels

Electron-Beam-Initiated Crosslinking of Methacrylated Alginate and Diacrylated Poly(ethylene glycol) Hydrogels

Gelatin‐Based Versus Alginate‐Based Hydrogels: Providing Insight in Wound Healing Potential

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