Absorbable Metal in Bone Surgery

McBride, Earl D.

doi:10.1001/jama.1938.02790530018007

Cited by 217 publications

(124 citation statements)

References 5 publications

Supporting

Mentioning

119

Contrasting

Unclassified

Order By: Relevance

“…[1][2][3][4][5][6][7][8] Degradation of bioabsorbable metals should be arrested until the fractured bone is sufficiently repaired to bear the load. However, the existing magnesium alloys do not show enough corrosion resistance for bone fixation devices.…”

Section: Introductionmentioning

confidence: 99%

Corrosion Behavior of Magnesium with Hydroxyapatite Coatings Formed by Hydrothermal Treatment

Hiromoto

Tomozawa

2010

Mater. Trans.

View full text Add to dashboard Cite

Corrosion resistance of magnesium alloys must be improved for their applications to orthopaedic bioabsorbable devices. Since hydroxyapatite (HAp) is chemically stable in the body and is the main component of bones, HAp coatings have been well studied to improve the corrosion resistance and osteoconductivity of magnesium alloys. In this study, highly crystallized HAp coatings were formed on pure magnesium with a single-step hydrothermal treatment using a C 10 H 12 CaN 2 Na 2 O 8 solution with various pH values. Morphology of the HAp coating varied depending on the pH value. Corrosion behavior of the HAp-coated magnesium was investigated by anodic polarization, impedance and immersion tests in a simulated body fluid. It was revealed that the corrosion resistance of pure magnesium was improved more than 10 times with the HAp coatings. Stable localized corrosion was prevented with the HAp coatings although the occurrence and moderation of unstable localized corrosion appeared to take place at the defects of the HAp coatings. The initial protectiveness of the HAp coating depended on the treatment condition. During 4-day immersion, the precipitated HAp sealed the defects of the HAp coatings, resulting in the negligible release of magnesium ions regardless of the treatment conditions.

show abstract

Section: Introductionmentioning

confidence: 99%

Corrosion Behavior of Magnesium with Hydroxyapatite Coatings Formed by Hydrothermal Treatment

Hiromoto

Tomozawa

2010

Mater. Trans.

View full text Add to dashboard Cite

show abstract

“…Previous studies had shown that screws and plates made of magnesium alloy corroded too quickly because of impurities in the alloy, which may have resulted in abandoning magnesium alloys for medical biomaterials [12,13]. In recent years, along with development in metallurgy, magnesium alloys have gained renewed interest as appropriate degradable biomaterials.…”

mentioning

confidence: 99%

In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy

Wang

Zhu

et al. 2012

Chin. Sci. Bull.

View full text Add to dashboard Cite

In this study, in vitro degradation and biocompatibility of Mg-Nd-Zn-Zr (NZK) alloy were investigated to determine its suitability as a degradable medical biomaterial. Its corrosion properties were evaluated by static immersion test, electrochemical corrosion test, scanning electron microscopy (SEM), and energy dispersive spectroscopic (EDS) analysis, and in vitro biocompatibilities were assessed by hemolysis and cytotoxicity tests. Pure magnesium was used as control. The results of static immersion test and electrochemical corrosion test in simulated body fluid (SBF) demonstrated that the addition of alloying elements could improve the corrosion resistance. The hemolysis test found that the hemolysis rate of calcium phosphate coated NZK alloy was 4.8%, which was lower than the safe value of 5%. The cytotoxicity test indicated that NZK alloy extracts did not significantly reduce MC 3 T 3 -E 1 cell viability. Hemolysis test and cytotoxicity test display excellent hemocompatibility and cytocompatibility of NZK alloy in vitro. Our data indicate that NZK alloy has excellent biocompatibility and thus can be considered as a potential degradable medical biomaterial for orthopedic applications.

show abstract

“…In addition to magnesium being biocompatible and essential to human metabolism, it has further advantages over other implant materials. These are as follows: (i) the density of Mg (1.74 g/cm 3 ) is similar to that of natural bone (1.75 g/cm 3 ), (ii) with alloying, high strength levels, up to 330 MPa, can be achieved, and (iii) its Young's Modulus E (45 GPa) is also similar to that of natural bone (40-57 GPa). However, the initial use of magnesium as degradable metal implants was found that the materials corroded too rapidly and large amounts of hydrogen (the corrosion product) were accumulated subcutaneous.…”

Section: Introductionmentioning

confidence: 78%

In vitro biodegradation behavior of magnesium and magnesium alloy

Wang

Shi

2011

J Biomed Mater Res

View full text Add to dashboard Cite

Magnesium has the potential to be used as degradable metallic biomaterial. For magnesium and its alloys to be used as biodegradable implant materials, their degradation rates should be consistent with the rate of healing of the affected tissue, and the release of the degradation products should be within the body's acceptable absorption levels. Conventional magnesium degrades rapidly, which is undesirable. In this study, biodegradation behaviors of high purity magnesium and commercial purity magnesium alloy AZ31 in both static and dynamic Hank's solution are systematically investigated. The in vitro test results show that magnesium purification and selective alloying are effective approaches to reduce the degradation rate of magnesium. In the static condition, the corrosion products accumulate on the materials surface as a protective layer, which results in a lower degradation rate than the dynamic condition. Anodized coating can significantly further reduce the degradation rate of magnesium. This study strongly indicates that magnesium can be used as degradable implant material as long as the degradation is controlled at a low rate. Magnesium purification, selective alloying, and anodized coating are three effective approaches to reduce the rate of degradation. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2011.

show abstract

Absorbable Metal in Bone Surgery

Cited by 217 publications

References 5 publications

Corrosion Behavior of Magnesium with Hydroxyapatite Coatings Formed by Hydrothermal Treatment

Corrosion Behavior of Magnesium with Hydroxyapatite Coatings Formed by Hydrothermal Treatment

In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy

In vitro biodegradation behavior of magnesium and magnesium alloy

Contact Info

Product

Resources

About