Absorbable, drug-loaded, extruded fiber for implantation

Nelson, Kevin D.

doi:10.1016/b978-1-78242-017-0.00006-4

Cited by 5 publications

(5 citation statements)

References 31 publications

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“…The die gives the final product and is so designed that the molten plastic evenly flows from the cylindrical profile to the profile shape. The extruded film is then cooled to set the film [108,109]. A diagrammatic representation of the melt extrusion method is shown in Figure 13.…”

Section: Composite Prepared From Melt Extrusion Methodsmentioning

confidence: 99%

Advances in P(VDF-TrFE) Composites: A Methodical Review on Enhanced Properties and Emerging Electronics Applications

P S,

Swain,

Rajput

et al. 2023

Condensed Matter

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Piezoelectric polymers are a class of material that belong to carbon–hydrogen-based organic materials with a long polymer chain. They fill the void where single crystals and ceramics fail to perform. This characteristic of piezoelectric polymers made them unique. Their piezoelectric stress constant is higher than ceramics and the piezoelectric strain is lower compared to ceramics. This study’s goal is to present the most recent information on poly(vinylidene fluoride) with trifluoroethylene P(VDF-TrFE), a major copolymer of poly(vinylidene fluoride) PVDF with piezoelectric, pyroelectric, and ferroelectric characteristics. The fabrication of P(VDF-TrFE) composites and their usage in a variety of applications, including in actuators, transducers, generators, and energy harvesting, are the primary topics of this work. The report provides an analysis of how the addition of fillers improves some of the features of P(VDF-TrFE). Commonly utilized polymer composite preparation techniques, including spinning, Langmuir–Blodgett (LB), solution casting, melt extrusion, and electrospinning are described, along with their effects on the pertinent characteristics of the polymer composite. A brief discussion on the literature related to different applications (such as bio-electronic devices, sensors and high energy-density piezoelectric generators, low mechanical damping, and easy voltage rectifiers of the polymer composite is also presented.

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Section: Composite Prepared From Melt Extrusion Methodsmentioning

confidence: 99%

Advances in P(VDF-TrFE) Composites: A Methodical Review on Enhanced Properties and Emerging Electronics Applications

P S,

Swain,

Rajput

et al. 2023

Condensed Matter

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“…The nanoparticles and polymer granules are mixed in a molten state to obtain a uniform and homogeneous dispersion of nanoparticles (Nelson, 2015). The molten polymer must withstand the shear stress and melt temperature to avoid degradation.…”

Section: Melt Extrusionmentioning

confidence: 99%

“…A collector plate is placed above the syringe tip, which electrically serves as a ground plate, and constant pressure is used. However, it is difficult to produce large quantities of fibers in a short time using the electrospinning process (Nelson, 2015).…”

Section: Electrospinningmentioning

confidence: 99%

Trends and challenges of biopolymer‐based nanocomposites in food packaging

Taherimehr

YousefniaPasha

Tabatabaeekoloor

et al. 2021

Comp Rev Food Sci Food Safe

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The ultimate goal of new food packaging technologies, in addition to maintaining the quality and safety of food for the consumer, is to consider environmental concerns and reduce its impacts. In this regard, one of the solutions is to use ecofriendly biopolymers instead of conventional petroleum-based polymers. However, the challenges of using biopolymers in the food packaging industry should be carefully evaluated, and techniques to eliminate or minimize their disadvantages should be investigated. Many studies have been conducted to improve the properties of biopolymer-based packaging materials to produce a favorable product for the food industry. This article reviews the structure of biopolymer-based materials and discusses the trends and challenges of using these materials in food packaging technologies with the focus on nanotechnology and based on recent studies.

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“…Hot melt extrusion (HME) is a form of 3D printing that applies high pressure through thermoplastic polymers at a critical temperature [ 1 ]. The process is often coupled with fused deposition modelling (FDM) to manufacture 3D designs by depositing molten material layer by layer to form a geometry sourced from design software [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

A Refined Hot Melt Printing Technique with Real-Time CT Imaging Capability

Muldoon

Ahmad

et al. 2022

Micromachines

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Personalised drug delivery systems with the ability to offer real-time imaging and control release are an advancement in diagnostic and therapeutic applications. This allows for a tailored drug dosage specific to the patient with a release profile that offers the optimum therapeutic effect. Coupling this application with medical imaging capabilities, real-time contrast can be viewed to display the interaction with the host. Current approaches towards such novelty produce a drug burst release profile and contrasting agents associated with side effects as a result of poor encapsulation of these components. In this study, a 3D-printed drug delivery matrix with real-time imaging is engineered. Polycaprolactone (PCL) forms the bulk structure and encapsulates tetracycline hydrochloride (TH), an antibiotic drug and Iron Oxide Nanoparticles (IONP, Fe3O4), a superparamagnetic contrasting agent. Hot melt extrusion (HME) coupled with fused deposition modelling (FDM) is utilised to promote the encapsulation of TH and IONP. The effect of additives on the formation of micropores (10–20 µm) on the 3D-printed surface was investigated. The high-resolution process demonstrated successful encapsulation of both bioactive and nano components to present promising applications in drug delivery systems, medical imaging and targeted therapy.

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Absorbable, drug-loaded, extruded fiber for implantation

Cited by 5 publications

References 31 publications

Advances in P(VDF-TrFE) Composites: A Methodical Review on Enhanced Properties and Emerging Electronics Applications

Advances in P(VDF-TrFE) Composites: A Methodical Review on Enhanced Properties and Emerging Electronics Applications

Trends and challenges of biopolymer‐based nanocomposites in food packaging

A Refined Hot Melt Printing Technique with Real-Time CT Imaging Capability

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