Absolute Stereostructure of Potent α-Glucosidase Inhibitor, Salacinol, with Unique Thiosugar Sulfonium Sulfate Inner Salt Structure from Salacia reticulata

The novel antihyperglycaemic action of hunteria umbellata seed fractions mediated via intestinal glucose uptake inhibition

“…This antihyperglycaemic effect was mediated via inhibition of intestinal glucose uptake mechanism since the HU Af significantly attenuated an increase in the post-absorptive glucose concentrations in the alloxan-induced hyperglycaemic rats. Literature has shown that certain alkaloids induce hypoglycaemia via inhibition of intestinal glucose uptake by inhibiting α-glucosidase activities (Yoshikawa et al, 2002;Fattorusso and Taglialatela-Scafati, 2007). In addition, it has been reported that medicinal plants rich in alkaloids usually exhibit hypoglycaemic activities (Svoboda et al, 1964;Yoshikawa et al, 2007;Okonta and Aguwa, 2007;Fuji et al, 2009).…”

Medicinal Foodstuffs. XXXI. Structures of New Aromatic Constituents and Inhibitors of Degranulation in RBL-2H3 Cells from a Japanese Folk Medicine, the Stem Bark of Acer nikoense.

“…2,6) During the course of our studies on bioactive constituents of natural medicines [7][8][9][10][11][12][13] and medicinal foodstuffs, [14][15][16][17][18][19] we have reported three new cyclic diarylheptanoids called acerosides B 1 (5) and B 2 (6) and aceroketoside (7) from the stem bark of A. nikoense as well as the inhibitory effects of the principal diarylheptanoids on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophages. 1) As a continuation of the characterization studies on bioactive constituents of the stem bark of A. nikoense, we have isolated four new aromatic compounds called rhododendroketoside (1), (Ϫ)-sakuraresinoside (2), acernikol (3), and nikoenoside (4) together with six known compounds (9, 14, 17, 27-29).…”

“…[2][3][4][5] In addition, the methanolic extract was reported to have hepatoprotective effects and (ϩ)-rhododendrol (15) was isolated as the active principle. 2,6) During the course of our studies on bioactive constituents of natural medicines [7][8][9][10][11][12][13] and medicinal foodstuffs, [14][15][16][17][18][19] we have reported three new cyclic diarylheptanoids called acerosides B 1 (5) and B 2 (6) and aceroketoside (7) from the stem bark of A. nikoense as well as the inhibitory effects of the principal diarylheptanoids on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophages. …”

Effects of the Sri Lankan medicinal plant, Salacia reticulata, in rheumatoid arthritis

“…The effects of SR on diabetes have already been reported. For example, it is known that SR contains such unique compounds as salacinol, kotalanol and mangiferin [30]. Salacinol and kotalanol were reported to inhibit a-glucosidase activity [28], while Mangiferin was reported to decrease the expression of fructose-1,6-bisphosphatase (FBP), a key enzyme involved in gluconeogenesis in the liver [9].…”