Absolute spike frequency as a predictor of surgical outcome in temporal lobe epilepsy

Ngo, Ly; Sperling, Michael R.; Skidmore, Christopher; Mintzer, Scott; Nei, Maromi

doi:10.1016/j.seizure.2017.03.008

Cited by 9 publications

(6 citation statements)

References 9 publications

(11 reference statements)

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“…They hypothesized that frequent spiking on scalp EEG may reflect propagation of spikes to the neocortex that is not resected during selective surgery, therefore indicating reduced likelihood of seizure freedom. Our findings are similar to what was reported by Ngo et al 35 in standard ATL in that IED frequency was not a predictor of surgical outcome after MRgLiTT of MTS.…”

Section: Discussionsupporting

confidence: 92%

Magnetic resonance‐guided laser interstitial thermal therapy: Correlations with seizure outcome

Kang¹,

Pickard

Bronder³

et al. 2021

Epilepsia

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This study was undertaken to identify clinical factors associated with seizure freedom after magnetic resonance-guided laser interstitial thermal therapy (MRgLiTT) in temporal lobe epilepsy patients with unilateral mesial temporal sclerosis (MTS). Methods: We identified 56 patients with magnetic resonance imaging-defined MTS who underwent MRgLiTT with at least 1 year of follow-up. Primary outcome was seizure freedom at 1 year. We examined the association of seizure freedom and the following clinical factors: age at surgery, gender, history of febrile seizures, history of focal to bilateral tonic-clonic seizures, duration of epilepsy at the time of surgery, frequency of interictal epileptiform discharges (IEDs), seizure frequency, and presence of bilateral IEDs.

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Section: Discussionsupporting

confidence: 92%

Magnetic resonance‐guided laser interstitial thermal therapy: Correlations with seizure outcome

Kang¹,

Pickard

Bronder³

et al. 2021

Epilepsia

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“…These parameters were selected based on previous work suggesting a correlation between focal slowing and ASL perfusion changes in tuberous sclerosis 60 , and between spikes and ASL perfusion changes in temporal lobe epilepsy 61 . Spike frequency was calculated considering all spikes noted in the first hour of wakefulness and in the first hour of non-rapid eye movement (NREM) sleep, where applicable 62 and dichotomized 63 in “frequent” at ≥ 60 spikes per hour and “non-frequent” at < 60 spikes per hour.…”

Section: Methodsmentioning

confidence: 99%

Lesion volume and spike frequency on EEG impact perfusion values in focal cortical dysplasia: a pediatric arterial spin labeling study

Gennari,

Bicciato,

Lo Biundo

et al. 2024

Sci Rep

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Arterial spin labelling (ASL), an MRI sequence non-invasively imaging brain perfusion, has yielded promising results in the presurgical workup of children with focal cortical dysplasia (FCD)-related epilepsy. However, the interpretation of ASL-derived perfusion patterns remains unclear. Hence, we compared ASL qualitative and quantitative findings to their clinical, EEG, and MRI counterparts. We included children with focal structural epilepsy related to an MRI-detectable FCD who underwent single delay pseudo-continuous ASL. ASL perfusion changes were assessed qualitatively by visual inspection and quantitatively by estimating the asymmetry index (AI). We considered 18 scans from 15 children. 16 of 18 (89%) scans showed FCD-related perfusion changes: 10 were hypoperfused, whereas six were hyperperfused. Nine scans had perfusion changes larger than and seven equal to the FCD extent on anatomical images. Hyperperfusion was associated with frequent interictal spikes on EEG (p = 0.047). Perfusion changes in ASL larger than the FCD corresponded to larger lesions (p = 0.017). Higher AI values were determined by frequent interictal spikes on EEG (p = 0.004). ASL showed FCD-related perfusion changes in most cases. Further, higher spike frequency on EEG may increase ASL changes in affected children. These observations may facilitate the interpretation of ASL findings, improving treatment management, counselling, and prognostication in children with FCD-related epilepsy.

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“…In contrast, Ngo et al 4 report a series of 47 patients, 62% with unilateral HcA, who underwent a temporal lobectomy. Absolute spike frequency was assessed on at least 1 hour of EEG data acquired during noninvasive inpatient EEG monitoring.…”

Section: Commentarymentioning

confidence: 96%

Do Interictal Rates Influence Treatment Outcomes in Temporal Lobe Epilepsy?

King-Stephens¹

2020

Epilepsy Curr

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Absolute spike frequency as a predictor of surgical outcome in temporal lobe epilepsy

Abstract: This study suggests that absolute spike frequency does not predict seizure outcome after anterior temporal lobectomy unlike in selective procedures, and should not be used as a prognostic factor in this population.

Cited by 9 publications

References 9 publications

Magnetic resonance‐guided laser interstitial thermal therapy: Correlations with seizure outcome

Magnetic resonance‐guided laser interstitial thermal therapy: Correlations with seizure outcome

Lesion volume and spike frequency on EEG impact perfusion values in focal cortical dysplasia: a pediatric arterial spin labeling study

Do Interictal Rates Influence Treatment Outcomes in Temporal Lobe Epilepsy?

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