Absolute spike frequency and etiology predict the surgical outcome in epilepsy due to amygdala lesions

Gyimesi, Csilla; Pannek, H. W.; Woermann, Friedrich G.; Elsharkawy, Alaa Eldin; Tomka-Hoffmeister, Maria; Hortsmann, Simone; Aengenendt, Jörg; Horváth, Réka; Schulz, Reinhard; Hoppe, Matthias; Janszky, József; Ebner, Alois

doi:10.1016/j.eplepsyres.2010.09.005

Cited by 6 publications

(7 citation statements)

References 19 publications

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“…21 Predictors for surgical failure after ATL are long duration of epilepsy, 22 older age at surgery, 13,14,22 focal to bilateral TC seizures, 20,22 and increased frequency of IEDs. 23,24 Overall, these predictors are similar to prognostication studies conducted in patients with temporal lobe epilepsy with and without MTS. [25][26][27][28] We found the presence of bilateral IEDs was associated with significantly lower odds of seizure freedom after MRgLiTT in univariate (p = .003, adjusted p = .04) and multivariate analyses (OR = .05, 95% CI = .01-.46, p = .008).…”

Section: Discussionsupporting

confidence: 63%

“…Favorable predictors for seizure freedom after ATL surgery in patients with MTS are male gender, 19 low seizure frequency, 19 unilateral interictal epileptiform discharges, 19,20 and history of febrile seizures 21 . Predictors for surgical failure after ATL are long duration of epilepsy, 22 older age at surgery, 13,14,22 focal to bilateral TC seizures, 20,22 and increased frequency of IEDs 23,24 . Overall, these predictors are similar to prognostication studies conducted in patients with temporal lobe epilepsy with and without MTS 25‐28 …”

Section: Discussionmentioning

confidence: 52%

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Magnetic resonance‐guided laser interstitial thermal therapy: Correlations with seizure outcome

Kang¹,

Pickard

Bronder³

et al. 2021

Epilepsia

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This study was undertaken to identify clinical factors associated with seizure freedom after magnetic resonance-guided laser interstitial thermal therapy (MRgLiTT) in temporal lobe epilepsy patients with unilateral mesial temporal sclerosis (MTS). Methods: We identified 56 patients with magnetic resonance imaging-defined MTS who underwent MRgLiTT with at least 1 year of follow-up. Primary outcome was seizure freedom at 1 year. We examined the association of seizure freedom and the following clinical factors: age at surgery, gender, history of febrile seizures, history of focal to bilateral tonic-clonic seizures, duration of epilepsy at the time of surgery, frequency of interictal epileptiform discharges (IEDs), seizure frequency, and presence of bilateral IEDs.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 52%

Magnetic resonance‐guided laser interstitial thermal therapy: Correlations with seizure outcome

Kang¹,

Pickard

Bronder³

et al. 2021

Epilepsia

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“…The amygdala, hippocampus, parahippocampal regions and their interconnected neural circuits have been implicated in the fear memory consolidation processes (Kim and Fanselow, 1992 ; Kjelstrup et al, 2002 ; Frankland et al, 2006 ; Botterill et al, 2014 ). Lesions to these brain regions have also been found in patients with temporal lobe epilepsy (TLE; Quesney, 1986 ; Hudson et al, 1993 ; Wolf et al, 1997 ; Bernasconi et al, 2003 ; Gyimesi et al, 2010 ; Meletti et al, 2014 ) and in animal models of TLE (Schwob et al, 1980 ; Ben-Ari, 1985 ; Pitkänen et al, 1998 ; Brandt et al, 2006 ; Toyoda et al, 2013 ). Moreover, patients with TLE and animal models of TLE with such lesions exhibit interictal emotional disturbances and impaired emotional learning that are known to be amygdala- and/or hippocampus-dependent (Hort et al, 1999 ; Vazquez and Devinsky, 2003 ; Kemppainen et al, 2006 ; Cardoso et al, 2009 ).…”

Section: Introductionmentioning

confidence: 99%

Reorganization of Basolateral Amygdala-Subiculum Circuitry in Mouse Epilepsy Model

Goh

et al. 2016

Front. Neuroanat.

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In this study, we investigated the reorganized basolateral amygdala (BLA)-subiculum pathway in a status epilepticus (SE) mouse model with epileptic episodes induced by pilocarpine. We have previously observed a dramatic loss of neurons in the CA1–3 fields of the hippocampus in epileptic mice. Herein, we observed a 43–57% reduction in the number of neurons in the BLA of epileptic mice. However, injection of an anterograde tracer, Phaseolus vulgaris leucoagglutinin (PHA-L) into the BLA indicated 25.63% increase in the number of PHA-L-immunopositive terminal-like structures in the ventral subiculum (v-Sub) of epileptic mice as compared to control mice. These data suggest that the projections from the basal nucleus at BLA to the vSub in epileptic mice are resistant to epilepsy-induced damage. Consequently, these epileptic mice exhibit partially impairment but not total loss of context-dependent fear memory. Epileptic mice also show increased c-Fos expression in the BLA and vSub when subjected to contextual memory test, suggesting the participation of these two brain areas in foot shock-dependent fear conditioning. These results indicate the presence of functional neural connections between the BLA-vSub regions that participate in learning and memory in epileptic mice.

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“…Invasive electrophysiological studies indicated that 5‐10% of patients with temporal lobe epilepsy (TLE) had seizure onset in the amygdalae . Neuropathological studies have demonstrated isolated amygdala abnormalities in patients with intractable TLE, and their etiologies varied: gangliogliomas, astrocytomas, vascular lesions, amygdala sclerosis, cortical dysplasia, and others …”

Section: Introductionmentioning

confidence: 99%

Temporal Lobe Epilepsy with Unilateral Amygdala Enlargement: Morphometric MR Analysis with Clinical and Pathological Study

Kimura

Sato

Saito

et al. 2014

Journal of Neuroimaging

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Absolute spike frequency and etiology predict the surgical outcome in epilepsy due to amygdala lesions

Cited by 6 publications

References 19 publications

Magnetic resonance‐guided laser interstitial thermal therapy: Correlations with seizure outcome

Magnetic resonance‐guided laser interstitial thermal therapy: Correlations with seizure outcome

Reorganization of Basolateral Amygdala-Subiculum Circuitry in Mouse Epilepsy Model

Temporal Lobe Epilepsy with Unilateral Amygdala Enlargement: Morphometric MR Analysis with Clinical and Pathological Study

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