ABSOLUTE rCBF CALIBRATION OF HMPAO SPECT USING XENON-133

Daicourt, J; Cauvin, J.C.; Miller, Bernard L.; Mena, I.

doi:10.1097/00003072-199310000-00063

Cited by 10 publications

(10 citation statements)

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“…Mild differences in quantitative data can be observed, depending on the methods of investigations. 44,45 According to the normative database collected in our laboratory on the same equipment used in the present study, the light red color, corresponding to 85% of perfusion, is taken as the conventional average norm. Two red squares below (75%) and 2 pink (deep and light pink) squares above the light red (95%) correspond to the lower and higher limits of normal perfusion.…”

Section: Methodsmentioning

confidence: 99%

Cerebral Perfusion in Patients With Chronic Neck and Upper Back Pain: Preliminary Observations

Bakhtadze¹,

Vernon

Каралкин

et al. 2012

Journal of Manipulative and Physiological Therapeutics

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Section: Methodsmentioning

confidence: 99%

Cerebral Perfusion in Patients With Chronic Neck and Upper Back Pain: Preliminary Observations

Bakhtadze¹,

Vernon

Каралкин

et al. 2012

Journal of Manipulative and Physiological Therapeutics

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“…191 Using currently available radiopharmaceuticals, perfusion SPECT accurately represents regional cerebral blood flow (rCBF). 193,194 Additional tracers have become available (one is commercially available) to measure receptor density and dopamine transporter site density. rCBF is a valid marker for neuronal activity over most of the physiological range of cerebral blood flow, because under most circumstances rCBF is tightly coupled to neuronal metabolism.…”

Section: Functional Neuroimaging-petmentioning

confidence: 99%

“…Commonly used radiopharmaceuticals currently include 133 Xe-derived rCBF values over the physiological range. 191,193,194 HMPAO has many advantages, including but not limited to low risk of allergic reaction, higher extraction, and better signal-to-noise ratio. 125 I-IMP is widely used outside the United States with excellent results.…”

Section: Functional Neuroimaging-petmentioning

confidence: 99%

“…SPECT facilities outnumber PET facilities 12-fold 191 . Using currently available radiopharmaceuticals, perfusion SPECT accurately represents regional cerebral blood flow (rCBF) 193 , 194 . Additional tracers have become available (one is commercially available) to measure receptor density and dopamine transporter site density.…”

Section: Neuroimaging and The Diagnosis Of Dementias And MCImentioning

confidence: 99%

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The diagnosis and evaluation of dementia and mild cognitive impairment with emphasis on SPECT perfusion neuroimaging

Henderson¹

2012

CNS Spectr.

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As the world population ages, the incidence of dementing illnesses will dramatically increase. The number of people afflicted with dementia is expected to quadruple in the next 50 years. Since the neuropathology of the dementias precedes clinical symptoms often by several years, earlier detection and intervention could be key steps to mitigating the progression and burden of these diseases. This review will explore methods of evaluating, differentiating, and diagnosing the multiple forms of dementia. Particular emphasis will be placed on the diagnosis of mild cognitive impairment-the precursor to dementia. Anatomical imaging; cerebrospinal fluid markers; functional neuroimaging, such as positron emission tomography and single photon emission tomography; and molecular imaging, such as amyloid marker imaging, will be assessed in terms of sensitivity and specificity. Cost will also be a consideration, as the growing population afflicted with dementia represents an increasingly large financial encumbrance to the healthcare systems of every nation. In the face of expensive new markers and limited availability of cyclotrons, single photon emission computer tomography (SPECT) provides relatively high sensitivity and specificity at a comparatively low overall cost.

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“…Pixels representing the top 45% of activity are used in creating the outside cortical 3D surface view of the brain, and the top 8%, 15%, and 45% pixels create the three-dimensional view of the interior of the patient's brain. These thresholds reflect the early work of I. Mena and colleagues [7][8][9] and have been used by Amen 6 in tens of thousands of SPECT scans. The term "3D SPECT" herein refers to the production of such SPECT images.…”

Section: S Ingle-photon Emission Computed Tomography (Spect)mentioning

confidence: 96%

Improved Outcomes Using Brain SPECT-Guided Treatment Versus Treatment-as-Usual in Community Psychiatric Outpatients: A Retrospective Case-Control Study

Thornton¹,

Schneider²,

McLean³

et al. 2014

JNP

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Brain single-photon emission computed tomography (SPECT) scans indirectly show functional activity via measurement of regional cerebral blood flow. Thirty patients at a community-based psychiatric clinic underwent brain SPECT scans. Changes in scoring of before-treatment and after-treatment scans correlated well with changes in patient Global Assessment of Functioning (GAF) scores before treatment and after treatment. Patients were retrospectively matched with controls with similar diagnoses and pretreatment GAF scores, and those who underwent SPECT-guided treatment improved significantly more than the control patients.

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ABSOLUTE rCBF CALIBRATION OF HMPAO SPECT USING XENON-133

Cited by 10 publications

References 0 publications

Cerebral Perfusion in Patients With Chronic Neck and Upper Back Pain: Preliminary Observations

Cerebral Perfusion in Patients With Chronic Neck and Upper Back Pain: Preliminary Observations

The diagnosis and evaluation of dementia and mild cognitive impairment with emphasis on SPECT perfusion neuroimaging

Improved Outcomes Using Brain SPECT-Guided Treatment Versus Treatment-as-Usual in Community Psychiatric Outpatients: A Retrospective Case-Control Study

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