Absolute lymphocyte counts predicts response to chemotherapy and survival in diffuse large B-cell lymphoma

Abstract

0.047 and 0.117, respectively. Overall, among the ALL patients only 20.6% carried at least one of the polymorphisms, while this rate was 34.6% within the control population. This difference is statistically significant (w 2 ¼ 5.2266, Po0.025). The results are summarized in Table 1. No significant differences were observed concerning ALL immunophenotype, sex, age at diagnosis, survival rate, or risk of relapse.These results implicate that the two polymorphisms A3V and T9I do not increase the risk of ALL in children, but rather suggest that they could convey a protective effect. Roddam et al.

CD4+ Tumor infiltrating lymphocytes are prognostic and independent of R‐IPI in patients with DLBCL receiving R‐CHOP chemo‐immunotherapy

“…We have also shown that a low lymphocyte count on its own appears to be a predictor of poor outcome. This confirms the findings of a number of recent studies that show that lymphopenia at diagnosis and also post-therapy is an adverse prognosticator [16,26,27]. There is also emerging data that the AMC may predict outcome in DLBCL [28].…”

The absolute monocyte and lymphocyte prognostic score predicts survival and identifies high-risk patients in diffuse large-B-cell lymphoma

“…The optimal cut-point for the ALC by receiver operating characteristic analysis was 1470/ml. However, as an ALC cutpoint of 1000/ml has been utilized in previous studies, 23,31,32 and failed to yield a significant difference in the ability to risk stratify patients by OS when compared with the cut-point selected by receiver operating characteristic analysis (data not shown), we chose to dichotomize the ALC using a cut-point of 1000/ml. The Cox proportional hazards model was used to evaluate the AMC and ALC as prognostic factors for PFS and OS and to adjust for other known prognostic variables included in the IPI.…”

“…For example, lymphopenia is a poor-risk feature in DLBCL patients treated with either CHOP or R-CHOP and in GCB-and non-GCB-type DLBCL. 23,31 More recently, the development of new-onset lymphopenia following autologousperipheral blood stem cell transplantation was associated with a significant increase in the risk of disease relapse. 32 Patients with an ALC o1000/ml following autologous-peripheral blood stem cell transplantation had an incidence of disease relapse of 92%, compared with a relapse rate of 19% among patients without lymphopenia.…”

“…However, geneexpression profiling studies in non-Hodgkin lymphomas (NHL) show that gene expression by tumor-infiltrating lymphocytes and myeloid-derived cells predict clinical outcomes. 3,19 Lymphocytes have an important role in immune surveillance in NHL, a view supported by the observation that lymphopenia is an adverse prognostic factor in NHL of various subtypes, including DLBCL, [20][21][22][23] and is widely considered an important surrogate marker of immunological reconstitution following stem cell transplantation in NHL. 24 Monocytes and lymphomaassociated macrophages (LAMs) contribute to the suppression of host anti-tumor immunity and the promotion of tumor angiogenesis.…”

Reply to ‘Claimed association of absolute lymphocyte count with therapeutic efficacy of radio-immunotherapy in patients with indolent lymphoma cannot be verified in an independence data set’ by Mark J Bishton et al

“…Recent reports have shown that the ALC at diagnosis in patients with diffuse large B-cell lymphoma is a prognostic factor for survival. 8 In the French study (LNH98B3), 9 diffuse large B-cell lymphoma patients that at diagnosis had a higher NK cell count, and not the ALC, experienced superior survival compared to those who did not. So that fact that the study by Bishton et al identified that patient with Letters to the Editor an ALC o1.0 Â 10 9 /l tended to do better does not discredit the role of the host immunity in affecting survival in patients treated with RIT, as it might be the possibility that in their low ALC group there was higher NK cells numbers explaining the observed better outcome.…”