Absolute blood eosinophil count and 1-year mortality risk following hospitalization with acute heart failure

Çıkrıkçıoğlu, Mehmet Ali; Soysal, Pınar; Dikerdem, Digdem; Çakırca, Mustafa; Kazancıoğlu, Rümeyza; Yolbaş, Servet; Erkal, Hafize; Hurşitoğlu, Mehmet; Karakose, Tulin Kurt; Kıskaç, Muharrem; Akkaya, Mehmet; Zorlu, Mehmet; Akkoyunlu, Muhammed Emin; Tükek, Tufan

doi:10.1097/mej.0b013e32834c67eb

Cited by 21 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increase in neutrophils has been associated with increased incidence of acute decompensated HF in patients admitted with acute MI . A reduced circulating eosinophil counts is associated with poor prognosis after HF hospitalization with higher rates of all‐cause mortality in these patients . In fact, our patients revealed these same tendencies, with significantly higher counts of neutrophils at time of hospitalization in both subgroups of patients, with or without infection.…”

Section: Discussionsupporting

confidence: 62%

Evaluation of Innate Immunity Biomarkers on Admission and at Discharge From an Acute Heart Failure Episode

Silva

Patrício

Bettencourt

et al. 2016

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 62%

Evaluation of Innate Immunity Biomarkers on Admission and at Discharge From an Acute Heart Failure Episode

Silva

Patrício

Bettencourt

et al. 2016

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

“…While other types of white blood cells such as neutrophils and monocytes are known to be involved in inflammatory processes that contribute to atherosclerosis,1 the role of eosinophils and lymphocytes in cardiovascular diseases is less well defined. Observational studies show worse prognosis among patients with heart failure with low eosinophil counts2 or low lymphocyte counts,3–5 prompting the question as to whether counts of these types of cell are also associated with onset of cardiovascular diseases in previously healthy people.…”

Section: Introductionmentioning

confidence: 99%

Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study

et al. 2016

View full text Add to dashboard Cite

BackgroundEosinophil and lymphocyte counts are commonly performed in clinical practice. Previous studies provide conflicting evidence of association with cardiovascular diseases.MethodsWe used linked primary care, hospitalisation, disease registry and mortality data in England (the CALIBER (CArdiovascular disease research using LInked Bespoke studies and Electronic health Records) programme). We included people aged 30 or older without cardiovascular disease at baseline, and used Cox models to estimate cause-specific HRs for the association of eosinophil or lymphocyte counts with the first occurrence of cardiovascular disease.ResultsThe cohort comprised 775 231 individuals, of whom 55 004 presented with cardiovascular disease over median follow-up 3.8 years. Over the first 6 months, there was a strong association of low eosinophil counts (<0.05 compared with 0.15–0.25×109/L) with heart failure (adjusted HR 2.05; 95% CI 1.72 to 2.43), unheralded coronary death (HR 1.94, 95% CI 1.40 to 2.69), ventricular arrhythmia/sudden cardiac death and subarachnoid haemorrhage, but not angina, non-fatal myocardial infarction, transient ischaemic attack, ischaemic stroke, haemorrhagic stroke, subarachnoid haemorrhage or abdominal aortic aneurysm. Low eosinophil count was inversely associated with peripheral arterial disease (HR 0.63, 95% CI 0.44 to 0.89). There were similar associations with low lymphocyte counts (<1.45 vs 1.85–2.15×109/L); adjusted HR over the first 6 months for heart failure was 2.25 (95% CI 1.90 to 2.67). Associations beyond the first 6 months were weaker.ConclusionsLow eosinophil counts and low lymphocyte counts in the general population are associated with increased short-term incidence of heart failure and coronary death.Trial registration numberNCT02014610; results.

show abstract

“…Yet, other studies suggest a protective role of EOS in CAD. A low EOS count independently predicts cardiovascular death and correlates negatively with death rates 14 . In the CALIBER study of 775,231 individuals aged 30 or older without CAD at baseline, a strong correlation occurred between low EOS count with heart failure (Hazard Ratio HR: 2.05), unheralded coronary death (HR: 1.94), ventricular arrhythmia/sudden cardiac death, and subarachnoid hemorrhage over 6 months of follow-up.…”

mentioning

confidence: 99%

Eosinophils improve cardiac function after myocardial infarction

et al. 2020

View full text Add to dashboard Cite

Clinical studies reveal changes in blood eosinophil counts and eosinophil cationic proteins that may serve as risk factors for human coronary heart diseases. Here we report an increase of blood or heart eosinophil counts in humans and mice after myocardial infarction (MI), mostly in the infarct region. Genetic or inducible depletion of eosinophils exacerbates cardiac dysfunction, cell death, and fibrosis post-MI, with concurrent acute increase of heart and chronic increase of splenic neutrophils and monocytes. Mechanistic studies reveal roles of eosinophil IL4 and cationic protein mEar1 in blocking H2O2- and hypoxia-induced mouse and human cardiomyocyte death, TGF-β-induced cardiac fibroblast Smad2/3 activation, and TNF-α-induced neutrophil adhesion on the heart endothelial cell monolayer. In vitro-cultured eosinophils from WT mice or recombinant mEar1 protein, but not eosinophils from IL4-deficient mice, effectively correct exacerbated cardiac dysfunctions in eosinophil-deficient ∆dblGATA mice. This study establishes a cardioprotective role of eosinophils in post-MI hearts.

show abstract

Absolute blood eosinophil count and 1-year mortality risk following hospitalization with acute heart failure

Abstract: AEC of AHF patients measured at admission was found to be a stronger predictor of mortality than all other hemogram parameters and this is consistent with the increased sympatho-adrenal activity theory.

Cited by 21 publications

References 0 publications

Evaluation of Innate Immunity Biomarkers on Admission and at Discharge From an Acute Heart Failure Episode

Evaluation of Innate Immunity Biomarkers on Admission and at Discharge From an Acute Heart Failure Episode

Low eosinophil and low lymphocyte counts and the incidence of 12 cardiovascular diseases: a CALIBER cohort study

Eosinophils improve cardiac function after myocardial infarction

Contact Info

Product

Resources

About