Absidia Corymbiferain an immune competent accident victim with multiple abdominal injuries: case report

Belfiori, Rita; Terenzi, Adelmo; Marchesini, L; Repetto, Antonella

doi:10.1186/1471-2334-7-46

Cited by 17 publications

(12 citation statements)

References 15 publications

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“…Interestingly, trauma‐related infections have been described in patients without obvious underlying immunosuppression . Superficial infections can occur in patients suffering from an immunosuppressive disorder, such as leukaemia or HIV, but also in premature infants and apparently healthy adult persons . They are characterised by rapidly developing extensive tissue necrosis leading to purple to black discolouration of the skin .…”

Section: Human Disease Caused By Lichtheimiamentioning

confidence: 99%

Mucormycoses caused byLichtheimiaspecies

Schwartze

Jacobsen

2014

Mycoses

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SummaryMucormycoses are life-threatening infections with fungi from the order Mucorales (Mucoromycotina). Although mucormycoses are uncommon compared to other fungal infections, e.g. aspergillosis and candidiasis, the number of cases is increasing especially in immunocompromised patients. Lichtheimia (formerly Absidia) species represent the second to third most common cause of mucormycoses in Europe. This mini review presents current knowledge about taxonomy and clinical relevance of Lichtheimia species. In addition, clinical presentation and risk factors will be discussed. Proper animal infection models are essential for the understanding of the pathogenesis and the identification of virulence factors of fungal pathogens. To date, several animal models have been used to study Lichtheimia infection. A brief overview of the different models and the main conclusions from the infection experiments is summarised in this review.

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Section: Human Disease Caused By Lichtheimiamentioning

confidence: 99%

Mucormycoses caused byLichtheimiaspecies

Schwartze

Jacobsen

2014

Mycoses

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“…corymbifera have been reported from rhinocerebral, cutaneous, pulmonary and disseminated infection. [5,6] A. corymbifera can present with cutaneous infection with successful outcome if treated early. [5,6] We isolated A. corymbifera with unusual presentation (as multiple discharging sinuses) from a diabetic patient.…”

Section: It Usually Causes Infection In Immunocompromised Patients Asmentioning

confidence: 99%

Fungal infections in the soft tissue: A study from a tertiary care center

Kindo

Rana

Rekha

et al. 2010

Indian Journal of Medical Microbiology

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Isolated fungal soft-tissue infections are uncommon but may cause severe morbidity or mortality, especially among immunosuppressed patients. In this study, a total of 56 soft-tissue specimens from patients with clinical suspicion of fungal infection collected at a tertiary care centre in Chennai during the period December 2005 to May 2007 were evaluated. Among the culture positives, majority were from diabetic patients. Among the 34 culture positives, the isolates consisted of Candida 12, Fusarium 4, Rhizopus 1 and Aspergillus 3 one each of Absidia corymbifera and Apophysomyces elegans. Treatment of fungal soft-tissue infection requires a team approach of surgeons, pathologists and microbiologists.

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“…These infections are typically managed with aggressive debridement and systemic antifungal medications, with limited success. [1][2][3][4][5][6][7][8] To date, there has been one article in the infectious disease literature describing the course of a severely injured combat casualty who died secondary to an aggressive actinomucor infection, 9 and we are aware of no literature describing ways to modify surgical technique to help improve survivorship in the face of these aggressive infections.…”

Section: Introductionmentioning

confidence: 99%

The Use of Dilute Dakin's Solution for the Treatment of Angioinvasive Fungal Infection in the Combat Wounded: A Case Series

et al. 2013

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Disseminated fungal infections are normally opportunistic infections in the immunocompromised population. Current literature has documented a high mortality rate with these infections in civilian trauma or as complications of severe burns. There is only one published case of fungal infection in a combat-injured individual to date, which resulted in mortality despite aggressive debridement and appropriate antifungal agents. We present here three patients in whom aggressive debridement, antifungals, and the addition of dilute Dakin's solution with negative pressure wound therapy was used to treat angioinvasive mold. Angioinvasive fungal infection continue to be one of the most aggressive and devastating infections that our combat-injured patients face. With the addition of dilute Dakin's solution, we successfully managed three critically ill patients. Previous literature had shown close to 30% mortality associated with cutaneous mucormycosis and the mortality rate approaches 100% with disseminated angioinvasive fungal infections. These results provide hope not only for the combat-injured patients being treated for both local and disseminated angioinvasive fungal infections, but also for the civilian trauma and immunocompromised patients.

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Absidia Corymbiferain an immune competent accident victim with multiple abdominal injuries: case report

Abstract: Background: We report a case of mucormycosis in a healthy 17-year-old accident victim with multiple abdominal injuries which was caused by infection with Absidia Corymbifera, a ubiquitous saphrophyte in the ground.

Cited by 17 publications

References 15 publications

Mucormycoses caused byLichtheimiaspecies

Mucormycoses caused byLichtheimiaspecies

Fungal infections in the soft tissue: A study from a tertiary care center

The Use of Dilute Dakin's Solution for the Treatment of Angioinvasive Fungal Infection in the Combat Wounded: A Case Series

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