Absidia corymbifera necrotizing cellulitis in an immunocompromised patient while on voriconazole treatment

Pasticci, Maria Bruna; Terenzi, Adelmo; Lapalorcia, Luigi Maria; Giovenale, Paolo; Pitzurra, Lucia; Costantini, Vincenzo; Lignani, Alessandra; Gurdo, Grazia; Verzini, Fabio; Baldelli, Franco

doi:10.1007/s00277-008-0468-x

Cited by 3 publications

(5 citation statements)

References 4 publications

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“…Interestingly, trauma‐related infections have been described in patients without obvious underlying immunosuppression . Superficial infections can occur in patients suffering from an immunosuppressive disorder, such as leukaemia or HIV, but also in premature infants and apparently healthy adult persons . They are characterised by rapidly developing extensive tissue necrosis leading to purple to black discolouration of the skin .…”

Section: Human Disease Caused By Lichtheimiamentioning

confidence: 99%

“…They are characterised by rapidly developing extensive tissue necrosis leading to purple to black discolouration of the skin . In individual cases involvement of deeper tissue, leading to necrotising fasciitis and cellulitis, has also been reported . In the most severe cases, cutaneous infections can progress to disseminated disease, especially in immunocompromised patients and premature infants .…”

Section: Human Disease Caused By Lichtheimiamentioning

confidence: 99%

“…37,40,42 Superficial infections can occur in patients suffering from an immunosuppressive disorder, such as leukaemia or HIV, but also in premature infants and apparently healthy adult persons. 42,[45][46][47][48][49][50][51][52] They are characterised by rapidly developing extensive tissue necrosis leading to purple to black discolouration of the skin. 45,53 In individual cases involvement of deeper tissue, leading to necrotising fasciitis and cellulitis, has also been reported.…”

Section: Clinical Presentation Of Lichtheimia Infectionsmentioning

confidence: 99%

“…45,53 In individual cases involvement of deeper tissue, leading to necrotising fasciitis and cellulitis, has also been reported. 40,46,54 In the most severe cases, cutaneous infections can progress to disseminated disease, especially in immunocompromised patients and premature infants. 47,55 In premature infants, Lichtheimia infections furthermore commonly affect the gastrointestinal tract, 56 often resembling necrotising enterocolitis.…”

Section: Clinical Presentation Of Lichtheimia Infectionsmentioning

confidence: 99%

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Mucormycoses caused byLichtheimiaspecies

Schwartze

Jacobsen

2014

Mycoses

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SummaryMucormycoses are life-threatening infections with fungi from the order Mucorales (Mucoromycotina). Although mucormycoses are uncommon compared to other fungal infections, e.g. aspergillosis and candidiasis, the number of cases is increasing especially in immunocompromised patients. Lichtheimia (formerly Absidia) species represent the second to third most common cause of mucormycoses in Europe. This mini review presents current knowledge about taxonomy and clinical relevance of Lichtheimia species. In addition, clinical presentation and risk factors will be discussed. Proper animal infection models are essential for the understanding of the pathogenesis and the identification of virulence factors of fungal pathogens. To date, several animal models have been used to study Lichtheimia infection. A brief overview of the different models and the main conclusions from the infection experiments is summarised in this review.

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Section: Human Disease Caused By Lichtheimiamentioning

confidence: 99%

Section: Human Disease Caused By Lichtheimiamentioning

confidence: 99%

Section: Clinical Presentation Of Lichtheimia Infectionsmentioning

confidence: 99%

Section: Clinical Presentation Of Lichtheimia Infectionsmentioning

confidence: 99%

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Mucormycoses caused byLichtheimiaspecies

Schwartze

Jacobsen

2014

Mycoses

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“…Another common clinical manifestation caused by Lichtheimia species is cutaneous and subcutaneous infections which are associated with contamination of wounds, either with plant material during accidents, or via non-sterile bandages or surgical dressings [15][16][17][18][19][20][21] . Superficial infections can occur in Immunosuppressive patients which are characterised by rapid tissue necrosis leading to purple to black discolouration of the skin [22][23][24][25][26][27][28][29] . In premature infants, Lichtheimia infections commonly affect the gastrointestinal tract often resembling necrotising enterocolitis [30][31] .…”

Section: Clinical Featuresmentioning

confidence: 99%

A Fatal Case of Otomycosis due to Lichtheimia Spp in an Immunocompromised Patient with a Brief Review of Lichtheimia

Gautam

Das

Agarwal

et al. 2022

ijirms

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The genus Lichtheimia consists of fungal species (Mucorales, Zygomycetes), which are ubiquitous soil inhabitants and represent important causative agents of mucormycoses in human and animals. Subsequent phylogenetic and physiological studies showed that Absidia-like fungi represent three separate lineages Absidia, Lentamyces, Lichtheimia. Only the last group has clinical relevance. Infection due to Lichtheimia spp is an infrequent opportunistic infection that can potentially be angioinvasive when affecting immunocompromised patient. In the present study we are discussing a case of A 68 yrs old male with type 2 diabetes, and chronic kidney disease, presented with right side otalgia with purulent discharge from right external auditory canal. This minireview throws light on fatal nature, various diagnostic modalities and treatment available for Lichtheimia.

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