Absent mesosternum in congenital heart disease

Steiner, Rudolf; Kricun, Morrie E.; Shapiro, J. R.

doi:10.2214/ajr.127.6.923

Cited by 14 publications

(1 citation statement)

References 3 publications

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“…A junction between the adult manubrium and body of the sternum seems not to correspond to a border between the intercostoclavicular mesenchyme and sternal band but rather to a line across the cranial part of the latter. The present discussion proposes the way in which partial absence of the sternum occurs (Steiner et al, 1976;Cottrill, 1998).…”

Section: Discussionmentioning

confidence: 94%

Morphogenesis of the Manubrium of Sternum in Human Embryos: A New Concept

Rodríguez‐Vázquez¹,

Verdugo-López²,

Garrido³

et al. 2012

The Anatomical Record

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To revisit many theories on fetal development of the manubrium of the sternum, we examined 25 mid-term fetuses at 6-9 weeks of gestation. The initial developmental stage of the manubrium was characterized by a distinct interclavicular mesenchyme that was continuous with the developing clavicles. Because parts of the clavicle in which endochondral ossification occurs originate from the neural crest, the interclavicular mesenchyme seems to be of the same origin. The sternal bands, possibly of the lateral plate origin, were restricted at the anterior ends of the ribs in the paired thoracic walls. The interclavicular mesenchyme extended caudally and laterally to reach the anterior ends of the first ribs, and thus the interclavicular mesenchyme expanded into the intercostoclavicular mesenchyme. Then, the primitive manubrium was delimited by the sternoclavicular joint and its related ligaments, all of which developed from the interclavicular and intercostoclavicular mesenchymes. Although the first ribs were attached to the intercostoclavicular mesenchyme, the former was vimentinnegative in contrast to the latter, positive mesenchyme. Soon afterwards, the small upper end of the sternal bands was integrated into the intercostoclavicular mesenchyme to form the primitive manubrium. The infrahyoid muscles and their supplying nerves maintained a close topographical relation to the interclavicular or intercostoclavicular mesenchyme, whereas the pectoralis major muscle kept attachments to the sternal bands. Consequently, the manubrium of sternum appeared to develop in a complex way at a junction area between derivatives of the neural crest, lateral plate, and somite. Anat Rec, 296:279-289,

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Section: Discussionmentioning

confidence: 94%