2010
DOI: 10.1038/jcbfm.2009.276
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Absence of the αvβ3 Integrin Dictates the Time-Course of Angiogenesis in the Hypoxic Central Nervous System: Accelerated Endothelial Proliferation Correlates with Compensatory Increases in α5β1 Integrin Expression

Abstract: Cerebral angiogenesis is an important adaptive response to hypoxia. As the alpha v beta 3 integrin is induced on angiogenic vessels in the ischemic central nervous system (CNS), and the suggested angiogenic role for this integrin in other systems, it is important to determine whether the alpha v beta 3 integrin is an important mediator of cerebral angiogenesis. alpha v beta 3 integrin expression was examined in a model of cerebral hypoxia, in which mice were subject to hypoxia (8% O(2)) for 0, 4, 7, or 14 days… Show more

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Cited by 40 publications
(48 citation statements)
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“…α 5 β 1 and α v β 3 are two major integrins expressed on the surface of endothelial cells [45]. We and others have shown that integrin α 5 β 1 , but not α v β 3 , clustered in focal contacts of endothelial cells during stressful cellular conditions (Figure 4B) or incubation with fibronectin [58][60]. In this study, we found that Robo4 formed a complex with fibronectin and integrin α 5 β 1 at low, basal levels in uninfected lymphatic endothelial cells (Figures 2B, 5A and 5B).…”
Section: Discussionmentioning
confidence: 85%
“…α 5 β 1 and α v β 3 are two major integrins expressed on the surface of endothelial cells [45]. We and others have shown that integrin α 5 β 1 , but not α v β 3 , clustered in focal contacts of endothelial cells during stressful cellular conditions (Figure 4B) or incubation with fibronectin [58][60]. In this study, we found that Robo4 formed a complex with fibronectin and integrin α 5 β 1 at low, basal levels in uninfected lymphatic endothelial cells (Figures 2B, 5A and 5B).…”
Section: Discussionmentioning
confidence: 85%
“…In previous studies, we showed that angiogenic vessels in the hypoxic and ischemic CNS strongly upregulate expression of fibronectin and its receptor α5β1 integrin (Li et al 2010b; Milner et al 2008a). Now, we addressed whether this holds true for remodeling vessels in the spinal cord of EAE mice.…”
Section: Resultsmentioning
confidence: 99%
“…We have shown that angiogenic vessels in the hypoxic CNS strongly upregulate expression of fibronectin and its receptors, α5β1 and αvβ3 (Li et al 2010; Milner et al 2008a). Now, we addressed whether a similar induction also occurs on angiogenic vessels in the ischemic CNS.…”
Section: Resultsmentioning
confidence: 99%
“…To determine whether this developmental program is recapitulated during angiogenesis in the adult CNS, we recently examined this process in a mouse model of cerebral hypoxia, in which a strong physiological angiogenic response occurs. This revealed strong induction of fibronectin and the two fibronectin receptors, α5β1 and αvβ3 integrins on angiogenic vessels (Li et al 2010; Milner et al 2008a). More recently, we have demonstrated the functional significance of these interactions, by showing that mice deficient in endothelial cell expression of the α5 integrin, show an attenuated angiogenic response to chronic cerebral hypoxia (Li et al, manuscript in preparation).…”
Section: Introductionmentioning
confidence: 98%