Absence of the interstitial cells of Cajal in patients with gastroparesis and correlation with clinical findings

Forster, Jameson; Damjanov, Ivan; Lin, Zhiyue; Sarosiek, Irene; Wetzel, Paul A.; McCallum, Richard W.

doi:10.1016/j.gassur.2004.10.001

Cited by 221 publications

(128 citation statements)

References 19 publications

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…The presence of interstitial cells of Cajal on full thickness gastric biopsies obtained at the time of stimulator insertion has been suggested to be predictive of clinical response [17]. Generally, this full thickness biopsy is obtained at the time that the stimulator is placed and results are not available to guide treatment.…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors for Clinical Improvement with Enterra Gastric Electric Stimulation Treatment for Refractory Gastroparesis

et al. 2007

View full text Add to dashboard Cite

The objectives of this study were to determine the clinical response to Enterra gastric electric stimulation (GES) in patients with refractory gastroparesis and to determine factors associated with a favorable response.Methods-This study was conducted in patients undergoing Enterra GES for refractory gastroparesis. Symptoms were scored before and after GES implantation using the Gastroparesis Cardinal Symptom Index (GCSI) with additional questions about abdominal pain and global clinical response.Results-During an 18-month period, 29 patients underwent GES implantation. Follow-up data were available for 28 patients, with average follow-up of 148 days. At follow-up, 14 of 28 patients felt improved, 8 remained the same, and 6 worsened. The overall GCSI significantly decreased with improvement in the nausea/vomiting sub-score and the post-prandial subscore, but no improvement in the bloating subscore or abdominal pain. The decrease in GCSI was greater for diabetic patients than idiopathic patients. Patients with main symptom of nausea/vomiting had a greater improvement than patients with the main symptom of abdominal pain. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript narcotic analgesics at the time of implant had a poorer response compared to patients who were not.Conclusions-GES resulted in clinical improvement in 50% of patients with refractory gastroparesis. Three clinical parameters were associated with a favorable clinical response: (1) diabetic rather than idiopathic gastroparesis, (2) nausea/vomiting rather than abdominal pain as the primary symptom, and (3) independence from narcotic analgesics prior to stimulator implantation. Knowledge of these three factors may allow improved patient selection for GES.

show abstract

Section: Discussionmentioning

confidence: 99%

Predictive Factors for Clinical Improvement with Enterra Gastric Electric Stimulation Treatment for Refractory Gastroparesis

et al. 2007

View full text Add to dashboard Cite

show abstract

“…ICCs are associated with vagal afferent nerves (Fox et al, 2000) and hence studies into the pathophysiology of ICC associated with gastroparesis may www.intechopen.com hold the key to advancing our understanding of the causes of gut motility disorders associated with diabetes. In some patients with severe diabetic gastroparesis, the number of ICC has been shown to be significantly reduced in different parts of gut using immunohistochemistry (He et al, 2001;Nakahara et al, 2002;Forster et al, 2005;Miller et al, 2008). Damage to ICC, pacemakers, and mediators of neuromuscular neurotransmission in the gastrointestinal tract contributes to the pathogenesis of diabetic gastroenteropathy in both patients and animal models.…”

Section: Pathophysiology Of Icc In Diabetic Gastroparesismentioning

confidence: 99%

Advances in Research on Pacemaking Function of Interstitial Cell of Cajal in Gastrointestinal Tract

Xu¹

2011

Modern Pacemakers - Present and Future

View full text Add to dashboard Cite

“…Oxidative stress induces not only gastric mucosal injury, but also gastric motility dysfunction, such as diabetic gastroparesis. Gastroparesis is thought to be caused by ROS-induced damage of the networks of the interstitial cells of Cajal [31].…”

Section: Introductionmentioning

confidence: 99%

Different pathways involved in the stimulatory effects of homocysteine on rat duodenal smooth muscle

et al. 2017

View full text Add to dashboard Cite

Recent studies have confi rmed that hyperhomocysteinemia is associated with gastrointestinal diseases; however, the direct effect of homocysteine on gastrointestinal reactivity still remains unknown. The aim of this study was to demonstrate how homocysteine may affect nitric oxide mediated duodenal relaxation and whether cholinergic receptors and K + channels take part in stimulating motility, as well as to explore whether oxidative stress is associated with homocysteine-mediated effects. Experiments were carried out on male rats, body mass 250-300 g. Two groups of animals were treated by i.p. application of saline and D,L-Hcy (0.6 μmol/g bm). After 2h of incubation, the duodenal segments were prepared for biochemical analysis and contractile response measurements in an organ bath with Tyrode's solution. Effects of TEA (10 mmol/L) and L-NAME (30 μmol/L) on duodenal contractility in the presence of D,L-Hcy (0.6 μmol/g bm) were investigated. Elevated homocysteine levels seem to be of crucial importance for the deterioration of contractility through nitric oxide mediated relaxation, and, in part, by activation of K + channels. Hcy showed direct promuscarinic effects, since 30 min pretreatment of rat duodenum signifi cantly enhanced the contractile effect of increasing concentrations of ACh (10 -9 -10 -2 mol/L). Catalase activity, superoxide dismutase, glutathione peroxidase and the total antioxidant system were reduced while the thiobarbituric acid-reactive substances level was elevated. Our data showed a consistent profi le of gastrointestinal injury elicited by sulfur-containing amino acid-homocysteine. This could contribute to explain, at least in part, the mechanisms involved in human gastrointestinal diseases associated to hyperhomocysteinemia.

show abstract

Absence of the interstitial cells of Cajal in patients with gastroparesis and correlation with clinical findings

Cited by 221 publications

References 19 publications

Predictive Factors for Clinical Improvement with Enterra Gastric Electric Stimulation Treatment for Refractory Gastroparesis

Predictive Factors for Clinical Improvement with Enterra Gastric Electric Stimulation Treatment for Refractory Gastroparesis

Advances in Research on Pacemaking Function of Interstitial Cell of Cajal in Gastrointestinal Tract

Different pathways involved in the stimulatory effects of homocysteine on rat duodenal smooth muscle

Contact Info

Product

Resources

About