Absence of symptomatic benefit of lansoprazole, clarithromycin, and amoxicillin triple therapy in eradication of Helicobacter pylori positive, functional (nonulcer) dyspepsia

Abstract

There was no difference in sustained improvement of dyspepsia symptoms when LCA was compared with placebo. An 82% cure rate of H. pylori infection was observed with LAC.

Clinical Outcomes of Eradication of Helicobacter pylori in Nonulcer Dyspepsia in a Population with a High Prevalence of Infection: Results of a 12-Month Randomized, Double Blind, Placebo-Controlled Study

“…We defined the main outcome measure as symptomatic improvement ≥50%. Other studies have defined as the principal outcome partial improvement (11,12,29) or, as we did, improvement of 50% in the symptoms (15). A reduction in the symptoms mean analyzed in our study has also been used as the outcome by many other authors (9, 11-14, 19, 30, 40).…”

“…Other trials allowed the use of aspirin or NSAIDs (10,11,13,15) or included patients with gastric erosions (9,11,13,14,19). We strongly believe that these factors have created potentially confounding factors in clinical trials that have estimated the impact of H. pylori eradication on nonulcer dyspeptic patients.…”

“…Clinical studies focusing on the symptomatic benefits of eradicating H. pylori infections in patients with nonulcer dyspepsia have yielded conflicting results (9,10). The majority of these studies were performed in low-prevalence H pylori infection populations (11)(12)(13)(14)(15). There are few studies reporting the consequences of eradicating these bacteria in infected functional dyspeptic patients in high-prevalence populations.…”

“…The inclusion of patients with abnormal endoscopicfindings, mainly erosive gastritis, in clinical trials aiming to evaluate the clinical implications of H. pylori eradication remains controversial. Most previous trials have allowed the inclusion of patients with gastric erosions without analyzing its influence on the results (9,11,13,14,19). Rome I (20) and II (2) criteria are unclear about the relevance of erosive gastritis.…”

Comparison of Gastric Wall Thicknesses with Hydrogastric Sonography in Functional Dyspepsia Patients

“…[6][7][8][9] Twoma inhypot he ti cal sub gro upswe reiden ti fi edinal mostallofthereports:"ul cer-li ke "and"dy smo ti lity-li ke "dyspep sia,thefor merbe ingcha rac te ri zedbyse ve ralas pects ofpa inandthelat terbysymptomssug ges ti veof im pa i redgas tro du o de nalmo ti lity. 7,8,10 Con ven ti o naltran sab do mi nalul tra so nicexami na ti onhasali mi tedva lu eforgascon ta i ninggastro in tes ti nal tract sin ce tech ni cal li mi ta ti ons donotper mitade ta i ledeva lu a ti onofthewallor theen do lu mi nalsur fa ce. 11,12 Tran sab do mi nalsonog raphyofawa ter-fil ledsto mach, hydro gas tric so nog raphy(HGS), isare centlyin tro du cedtechni qu e,andcanim pro vetheima gequ a litydu ring exa mi na ti on,al lo wingsa tis fac toryvi su a li za ti onof thegas tricwallanditsdi sor ders.Thismet hodhas al sobe enre por tedtoha vehighsen si ti vityandspeci fi cityinthedi ag no sisandsta gingofgas triccar cino mas.…”