Absence of Sickling Phenomenon of the Red Blood Corpuscle Among Brazilian Indians

Silva, E. M. Da

doi:10.1126/science.107.2774.221

Cited by 18 publications

(6 citation statements)

References 9 publications

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“…This resulted in 4 sickle cell traits among the neonate samples obtained from the Zaans Medical Center, which were confirmed with a classic sickle cell test. 20 One sample showed HbBart's (FAST peak ¼ 8.9%) and DNA analysis confirmed a 2a 3.7 deletion on one of the a-genes (see Figure 1b).…”

Section: Validation Bio-rad Vnbsmentioning

confidence: 96%

Implementing Neonatal Screening for Haemoglobinopathies in the Netherlands

et al. 2010

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Background The birth prevalence of severe haemoglobinopathies such as sickle cell disease (SCD) in the Netherlands has been estimated to be at least 50 newborns per year. Neonatal screening for SCD was added to the Dutch screening programme in January 2007. We here evaluated three high performance liquid chromatography (HPLC) systems for application in neonatal screening for haemoglobinopathies, and present the results of a subsequent pilot screening programme. Methods The Variant NewBorn Screening (Vnbs) HPLC system (Bio-Rad) was validated by analysing 131 blood samples and blood mixtures. Subsequently, the performance of the G7 (Tosoh BioScience) and Ultra (Primus Corporation) was compared with the Vnbs. The three HPLC analysers were tested in a pilot screening programme on 21,969 dried blood spot samples from the routine Dutch neonatal screening programme.Results The pilot screening resulted in 188 abnormal patterns. The three HPLC devices presented comparable within-and between-run precision and detected the abnormal samples similarly. The high throughput, sampling systems, presentation of results, and integration of the chromatograms, however, were different. Conclusion All three analysers detected the same abnormal haemoglobins satisfactorily, but integrated the chromatograms with variable imprecision. Comparison of the results suggested that the Bio-Rad Vnbs was the preferred system. However, software adjustments were required to improve the diagnostic potential of this device for screening for b-and a-thalassaemia. BACKGROUND Haemoglobinopathies

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Section: Validation Bio-rad Vnbsmentioning

confidence: 96%

Implementing Neonatal Screening for Haemoglobinopathies in the Netherlands

et al. 2010

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“…After identification of an HbS-like fraction during the HPLC analysis, confirmation was done using the classic sickle cell test (Da Silva, 1948).…”

Section: Basic Analysismentioning

confidence: 99%

Carrier diagnostics and prevention of hemoglobinopathies in early pregnancy in The Netherlands: a pilot study

et al. 2006

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This pilot study shows that (1) as predicted the prevalence of risk-related HbP and of alpha(+)-thalassemia is high in the immigrant population. (2) The compliance with carrier analysis in both native Dutch and immigrants is virtually total and (3) carrier diagnosis in early pregnancy and partner analysis in Hospital Laboratories is possible and is an effective tool for primary prevention of HbP in The Netherlands.

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“…Araujo, 1961, p.90). In the state of Bahia, physicians Álvaro Pontes Bahia, João Pedroza Cunha, and José Peroba (1949) performed blood analyses on five hundred children at a clinic of the Bahian League Against Infant Mortality (Liga Bahiana Contra a Mortalidade Infantil). Like hematologist João Maia de Mendonça, the physicians in Bahia used Roquette-Pinto's racial categories.…”

Section: Juliana Manzoni Cavalcanti Marcos Chor Maiomentioning

confidence: 99%

“…In turn, this lingering doubt fed the persistent Brazilian idea that sickle cell anemia was heavily influenced by miscegenation. We can observe this lack of definition about the presence of the disease among whites in an article published in the Jornal de Pediatria by Asdrúbal Costa (1949) The conviction that miscegenation played a role in the epidemiology of sickle cell anemia in Brazil, plus the failure to prove that the disease was racially specific, left Brazilian physicians with uncertainties and hampered their efforts to define the disease. In the next section, we will see how investigators began searching for sickle cells among indigenous populations in their attempts to clarify the question of a correlation between sickle cell anemia and the black race.…”

Section: Juliana Manzoni Cavalcanti Marcos Chor Maiomentioning

confidence: 99%

“…In 1949, the world's understanding of sickle cell anemia changed yet again, when Pauling and collaborators (1949) defined it as a molecular disease. Although Pauling's role in this new discovery is a matter of controversy (Feldman, Tauber, 1997), his study was a milestone in representations of sickle cell anemia and carriers of sickle cells (Wailoo, 1997).…”

Section: Final Considerationsmentioning

confidence: 99%

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Entre negros e miscigenados: a anemia e o traço falciforme no Brasil nas décadas de 1930 e 1940

Cavalcanti

Maio

2011

Hist. cienc. saude-Manguinhos

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Aborda os estudos médicos e científicos sobre a anemia falciforme publicados no Brasil nas décadas de 1930 e 1940. A miscigenação foi apontada, pela maioria dos médicos e cientistas, como interferência significativa na epidemiologia da doença no país. Destaca a atuação do hematologista do Instituto Oswaldo Cruz Ernani Martins da Silva, que efetuou análises sanguíneas no interior no Brasil para determinar os grupos populacionais miscigenados e puros, baseado na identificação de hemácias falciformes e da distribuição racial dos grupos sanguíneos. Analisam-se as ambivalências existentes na associação entre a anemia falciforme e 'raça negra' durante os anos de 1930 e 1940 no Brasil.

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Absence of Sickling Phenomenon of the Red Blood Corpuscle Among Brazilian Indians

Cited by 18 publications

References 9 publications

Implementing Neonatal Screening for Haemoglobinopathies in the Netherlands

Implementing Neonatal Screening for Haemoglobinopathies in the Netherlands

Carrier diagnostics and prevention of hemoglobinopathies in early pregnancy in The Netherlands: a pilot study

Entre negros e miscigenados: a anemia e o traço falciforme no Brasil nas décadas de 1930 e 1940

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