Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis

Gangoda, Lahiru; Schenk, Robyn L; Best, Sarah A.; Nedeva, Christina; Louis, Cynthia; D'Silva, Damian B; Fairfax, Kirsten; Jarnicki, Andrew G.; Puthalakath, Hamsa; Sutherland, Kate D.; Strasser, Andreas; Herold, Marco J.

doi:10.1038/s41418-021-00839-3

Cited by 9 publications

(8 citation statements)

References 49 publications

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“…Neutrophils are considered crucial leukocytes in the initial immune response in sepsis ( 81 – 83 ). Neutrophils undergo migration from the bloodstream to sites of infection in response to inflammatory signals.…”

Section: Roles Of Bacterial Ev-host Interaction In Sepsismentioning

confidence: 99%

Bacteria-derived extracellular vesicles: endogenous roles, therapeutic potentials and their biomimetics for the treatment and prevention of sepsis

Effah,

Ding,

Drokow

et al. 2024

Front. Immunol.

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Sepsis is one of the medical conditions with a high mortality rate and lacks specific treatment despite several years of extensive research. Bacterial extracellular vesicles (bEVs) are emerging as a focal target in the pathophysiology and treatment of sepsis. Extracellular vesicles (EVs) derived from pathogenic microorganisms carry pathogenic factors such as carbohydrates, proteins, lipids, nucleic acids, and virulence factors and are regarded as “long-range weapons” to trigger an inflammatory response. In particular, the small size of bEVs can cross the blood-brain and placental barriers that are difficult for pathogens to cross, deliver pathogenic agents to host cells, activate the host immune system, and possibly accelerate the bacterial infection process and subsequent sepsis. Over the years, research into host-derived EVs has increased, leading to breakthroughs in cancer and sepsis treatments. However, related approaches to the role and use of bacterial-derived EVs are still rare in the treatment of sepsis. Herein, this review looked at the dual nature of bEVs in sepsis by highlighting their inherent functions and emphasizing their therapeutic characteristics and potential. Various biomimetics of bEVs for the treatment and prevention of sepsis have also been reviewed. Finally, the latest progress and various obstacles in the clinical application of bEVs have been highlighted.

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Section: Roles Of Bacterial Ev-host Interaction In Sepsismentioning

confidence: 99%

Bacteria-derived extracellular vesicles: endogenous roles, therapeutic potentials and their biomimetics for the treatment and prevention of sepsis

Effah,

Ding,

Drokow

et al. 2024

Front. Immunol.

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“…Among the anti-apoptotic BCL2 proteins, BCL2 related protein A1 (BCL2A1, best known as A1) seems to exert a crucial role in this setting, as Bcl2a1 deletion aggravated lung injury in mice subjected to hyperoxia [ 492 ], while lung-specific overexpression of BCL2 did not confer protection to mice exposed to excessive oxygen supply [ 493 ]. That said, no critical cytoprotective effect of A1 was seen in acute lung inflammation and peritonitis [ 494 ]. Intrinsic apoptosis has also been reported to be involved in pulmonary fibrosis [ 495 ].…”

Section: Intrinsic Apoptosis In Diseasementioning

confidence: 99%

Apoptotic cell death in disease—Current understanding of the NCCD 2023

et al. 2023

Self Cite

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Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

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“…These three have DNA and protein sequences that are more than 95% homologous, but BCL-2A1c encodes a pseudogene. Moreover, there is only one BCL-2A1 gene in human [120] [121]. BFL-1 shares structural similarities with other anti-apoptotic proteins.…”

Section: Bfl-1mentioning

confidence: 99%

Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic Context

Paul¹,

Saddam²,

Habib³

et al. 2023

Preprint

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Apoptosis, also known as the programmed death of cells, is responsible for maintaining the homeostasis of tissues and this function is carried out by caspases. The process of apoptosis is carried out via two distinct pathways: the extrinsic pathway, which is governed by death receptors, and the intrinsic pathway, also known as the mitochondrial pathway. The BCL-2 protein family encoded by the BCL-2 gene, located at the 18q21.33 chromosomal location, is in charge of regulating the intrinsic pathway, which is responsible for inducing cell death via the permeabilization of the mitochondrial membrane and the release of apoptosis - inducing components. The BCL-2 homology (BH1, BH2, BH3, BH4) domains of this family proteins are crucial for their functioning and their common BH domains allow interactions between members of the same family and can also serve as indications of pro- or anti-apoptotic activity. A direct correlation may be shown between the overexpression of BCL-2 and the postponement of cell death. It has been determined that a change in the expression of BCL-2 is the root cause of a variety of malignancies, including lung, breast, melanoma, and chronic lymphocytic leukemia, Multiple Sclerosis, Diabetes. In this review, we discuss the therapeutic potential of regulating BCL-2 family connections and their relevance to health and disease.

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Absence of pro-survival A1 has no impact on inflammatory cell survival in vivo during acute lung inflammation and peritonitis

Cited by 9 publications

References 49 publications

Bacteria-derived extracellular vesicles: endogenous roles, therapeutic potentials and their biomimetics for the treatment and prevention of sepsis

Bacteria-derived extracellular vesicles: endogenous roles, therapeutic potentials and their biomimetics for the treatment and prevention of sepsis

Apoptotic cell death in disease—Current understanding of the NCCD 2023

Emerging Biomarkers and Potential Therapeutics of the BCL-2 Protein Family: The Apoptotic and Anti-Apoptotic Context

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