Absence of p53 Mutations in Squamous Carcinomas of the Tongue in Nonsmoking and Nondrinking Patients Younger Than 40 Years

Oral cancer in young adults: report of three cases and review of the literature

“…12 In oral cancer of the young, p53 mutations have been reported as being absent in non-smoking and non-drinking patients. 13 Many young patients with oral cancer have a history of smoking, as two of the cases in the present report, so for these p53 may play a role but in the remainder of patients there is likely to be some other, as yet undetermined, genetic change. An increased susceptibility to carcinogenic agents has been reported in younger adult patients who have developed oral cancer, the details of which are outside the scope of this article and have been reviewed in a recent paper.…”

Head and neck cancer in young people: a series of 52 SCCs of the oral tongue in patients aged 35 years or less

“…This effort was necessary because of the low incidence of SCCOT in this age group, which ranged from 0.9 to 1.5% [7,8].…”

p53 codon 72 polymorphism and susceptibility malignancy of colorectal cancer in Taiwan

“…The p53 codon 72 arginine polymorphism does not appear to represent a significant risk factor for the development of cervical cancer in the white UK populations studied (Rosenthal et al 1998). The p53 codon 72 polymorphism has been implicated as a risk factor in several human cancers (Sorensen et al 1997;Buller et al 1997;Sjalander et al 1996) individuals who are proline homozygotes have been shown to have a greater risk of developing lung cancer (Wang et al 1999;Jin et al 1995), although the p53 codon 72 polymorphism is not associated with cutaneous malignancies in a Celtic population (O'Connor et al 2001). In our study, there were significant differences in the distribution of polymorphism of codon 72 from A to D in Dukes classification of colorectal cancer.…”