2024
DOI: 10.3389/fneur.2024.1435749
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Absence of oncomodulin increases susceptibility to noise-induced outer hair cell death and alters mitochondrial morphology

Kaitlin E. Murtha,
Weintari D. Sese,
Kiah Sleiman
et al.

Abstract: Cochlear outer hair cells (OHCs) play a fundamental role in the hearing sensitivity and frequency selectivity of mammalian hearing and are especially vulnerable to noise-induced damage. The OHCs depend on Ca2+ homeostasis, which is a balance between Ca2+ influx and extrusion, as well as Ca2+ buffering by proteins and organelles. Alterations in OHC Ca2+ homeostasis is not only an immediate response to noise, but also associated with impaired auditory function. However, there is little known about the contributi… Show more

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