Absence of Mutagenic Effects of 2.45 GHz Radiofrequency Exposure in Spleen, Liver, Brain, and Testis of lacZ-Transgenic Mouse Exposed in Utero

Ono, Tetsuya; Saito, Yûsuke; Komura, Jun‐ichiro; Ikehata, Hironobu; Tarusawa, Yoshiaki; Nojima, Toshio; Goukon, Katsuo; Ohba, Yoshifumi; Wang, Jianqing; Fujiwara, Osamu; Sato, Risaburo

doi:10.1620/tjem.202.93

Cited by 35 publications

(9 citation statements)

References 24 publications

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“…12 In previous studies, it was reported that EMR produced from mobile phones may affect the immune, nervous, hematological and urinary systems as well as the cardiac functions, genetics and the normal growth and development of humans. [12][13][14] In their study, Ono et al 15 could not determine any significant difference in DNA mutation between the non-exposed group and the embryos exposed to EMR for 16 hours daily for 15 days. However, EMR produced from mobile phones appears to have harmful effects on the human body in two different ways.…”

Section: Discussionmentioning

confidence: 78%

The effect of exposure of rats during prenatal period to radiation spreading from mobile phones on renal development

et al. 2014

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Background: The aim of this study was to investigate the effects of exposure to a 900-MHz electromagnetic field (EMF) produced by mobile phones on the renal development of prenatal rats. Histopathological changes and apoptosis in the kidneys, together with levels of urea, creatinine and electrolyte in serum were determined. Methods: A total of 14 Sprague-Dawley rats were studied. Pregnant rats were divided into two equal groups: a control group and an EMF-exposed group. The study group was exposed to 900-MHz of EMF during the first 20 days of pregnancy, while the control group was unexposed to EMF. Sections obtained from paraffin blocks were stained for caspase-3 by immunohistochemistry, hematoxylin-eosin and Masson's trichrome. Results: Mild congestion and tubular defects, and dilatation of Bowman's capsule were observed in the kidney tissues of rats in the exposed group. Apoptosis was evaluated using anti-caspase-3; stronger positive staining was observed in the renal tubular cells in the study group than those of the control group. Although there was a significant difference between the study and control groups in terms of K + level (p50.05), no significant difference was observed in the other parameters studied (p40.05). Conclusion: Our study shows that the electromagnetic waves propagated from mobile phones have harmful effects on the renal development of prenatal rats.

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Section: Discussionmentioning

confidence: 78%

The effect of exposure of rats during prenatal period to radiation spreading from mobile phones on renal development

et al. 2014

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“…However, we could not detect any changes in AO test outcome in the different animal groups. Ono et al (2004) used DNA sequence technique and indicated that RF of small bursts is not mutagenic in mouse when exposed in utero. Aitken et al (2005), using power electrophoresis, found a statistically significant genotoxic effect on epididymal sperm with damage to mitochondrial DNA and the nuclear ß‐globin locus.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Effects of exposure to a mobile phone on testicular function and structure in adult rabbit

2010

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The accumulating effects of exposure to electromagnetic radiation emitted by a conventional mobile phone (standby position) on the testicular function and structure are not yet fully investigated. To study these effects longitudinally, a total of 24 adult male rabbits were randomly and equally divided into three groups. Rabbits in the first (phone) group were exposed, in specially designed cages, to radio frequency emitted from the mobile phone (800 MHz) in a standby position opposite to that of testes for 8 h daily for 12 weeks. The second group consisted of the stress controls which were kept in the same kind of cages to appreciate any cage-induced anxiety. The third group included the ordinary controls which were kept in the conventional roomy cages. Semen analysis and sperm function tests (viability, hypo-osmotic swelling and acridine orange) were conducted weekly. Histological testicular sections and serum total testosterone were also evaluated. A drop in the sperm concentration appeared in the phone group at week 6. This became statistically significant at week 8, compared with the two control (stress and ordinary) groups (133, 339 and 356 x 106/mL, respectively) and to the initial sperm count (341 x 106/mL) of this group. Motile sperm population showed similarity amongst the three study groups until week 10 when it declined significantly, and thereafter in the phone and stress control groups, with more significant decline in the phone animals (50, 61 and 72.4%, respectively). Histological examination showed also a significant decrease in the diameter of seminiferous tubules in the phone group vs. the stress and ordinary controls (191 microm vs. 206 and 226 microm, respectively). The other study points did not show any difference. In conclusion, low intensity pulsed radio frequency emitted by a conventional mobile phone kept in the standby position could affect the testicular function and structure in the adult rabbit.

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“…2004). There is an absence of mutagenic effects of 2450‐MHz radio frequency exposure in various tissues of lacZ‐transgenic mice exposed in utero (Ono et al. 2004).…”

Section: Resultsmentioning

confidence: 99%

RAPID AND EFFICIENT GENERATION OF PCR TEMPLATES FROM ESCHERICHIA COLI, SACCHAROMYCES CEREVISIAE AND ORYZA SATIVA USING A MICROWAVE AND BY BOILING

He¹,

Luo²,

Wang³

et al. 2005

Rapid Methods Automation Mic

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Simple methods for the preparation of polymerase chain reaction (PCR) templates from Escherichia coli, Saccharomyces cerevisiae and Oryza sativa using a microwave and by boiling are described without the need for any special chemical reagent such as a detergent. The microwave and boiling methods were robust for the preparation of both plasmid and genomic templates of E. coli, as was the boiling approach for S. cerevisiae DNA. The microwave procedure was only suitable for dry yeast colonies with fair efficiency as absence of water (H2O) was critical for a successful PCR. Oryza sativa genomic DNA was amplified with both approaches with satisfactory efficiency. Escherichia coli plasmids can be prepared using a microwave with a yield equivalent to 15–20% of an alkaline lysis mini‐prep. PCR templates were also efficiently generated from Pichia pastoris and Ganoderma lucidum by using the boiling method.

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Absence of Mutagenic Effects of 2.45 GHz Radiofrequency Exposure in Spleen, Liver, Brain, and Testis of lacZ-Transgenic Mouse Exposed in Utero

Cited by 35 publications

References 24 publications

The effect of exposure of rats during prenatal period to radiation spreading from mobile phones on renal development

The effect of exposure of rats during prenatal period to radiation spreading from mobile phones on renal development

Retracted: Effects of exposure to a mobile phone on testicular function and structure in adult rabbit

RAPID AND EFFICIENT GENERATION OF PCR TEMPLATES FROM ESCHERICHIA COLI, SACCHAROMYCES CEREVISIAE AND ORYZA SATIVA USING A MICROWAVE AND BY BOILING

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