Absence of multiplicative interactions between occupational lung carcinogens and tobacco smoking: a systematic review involving asbestos, crystalline silica and diesel engine exhaust emissions

Zoghbi, Mohamad El; Salameh, Pascale; Stücker, Isabelle; Brochard, Patrick; Delva, Fleur; Lacourt, Aude

doi:10.1186/s12889-017-4025-1

Cited by 9 publications

(6 citation statements)

References 50 publications

(51 reference statements)

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“…Although the interactive role of smoking for asbestos-related mesothelioma was reported, 30,31 we did not observe any substantial difference on the effect of neighborhood asbestos exposure in a stratified analysis by smokers and non-smokers.…”

Section: Ta B L E 4 (Continued)contrasting

confidence: 75%

Association of mesothelioma deaths with neighborhood asbestos exposure due to a large‐scale asbestos‐cement plant

et al. 2023

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A causal relationship between mesothelioma and occupational asbestos exposure is well known, while some studies have shown a relationship to non-occupational exposures. The aim of this study was to quantify the risk of mesothelioma death associated with neighborhood asbestos exposure due to a large-scale asbestos-cement (AC) plant in Amagasaki, Japan, adjusting properly risk factors including occupational exposures.We conducted a nested case-control study in which a fixed population of 143,929 residents who had been living in Amagasaki City between 1975 and 2002 were followed from 2002 to 2015. All 133 cases and 403 matched controls were interviewed about their occupational, domestic, household, and neighborhood asbestos exposures. Odds ratios (ORs) for mesothelioma death associated with the neighborhood exposure were estimated by a conditional logistic-regression model. For quantitative assessments for neighborhood exposure, we adopted cumulative indices for individuals' residential histories at each residence-specific asbestos concentration multiplied by the duration during the potential exposure period of 1957-1975 (crocidolite). We observed an increasing, dose-dependent risk of mesothelioma death associated with neighborhood exposure, demonstrating that ORs in the highest quintile category were 21.4 (95% confidence interval [CI] 5.8-79.2) for all, 23.7 (95% CI 3.8-147.2) for males, and 26.0 (95% CI 2.8-237.5) for females compared to the lowest quintile, respectively.A quantitative assessment for risk of mesothelioma deaths, adjusting for occupational and non-occupational exposures separately, showed a dose-dependent association with neighborhood exposure and no substantial gender differences in magnitude.

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Section: Ta B L E 4 (Continued)contrasting

confidence: 75%

Association of mesothelioma deaths with neighborhood asbestos exposure due to a large‐scale asbestos‐cement plant

et al. 2023

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“…It is accepted that tobacco (especially cigarette) smoke and asbestos functionally interact in the causation of lung cancer; however, the type and strength of this interaction have occasionally been the issue if debate [34]. It is our opinion that the effect is synergistic, i.e., the combined effect is greater than the sum of the individual effects.…”

mentioning

confidence: 99%

Asbestos, Smoking and Lung Cancer: An Update

Klebe

Leigh

Henderson

et al. 2019

IJERPH

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This review updates the scientific literature concerning asbestos and lung cancer, emphasizing cumulative exposure and synergism between asbestos exposure and tobacco smoke, and proposes an evidence-based and equitable approach to compensation for asbestos-related lung cancer cases. This update is based on several earlier reviews written by the second and third authors on asbestos and lung cancer since 1995. We reevaluated the peer-reviewed epidemiologic studies. In addition, selected in vivo and in vitro animal studies and molecular and cellular studies in humans were included. We conclude that the mechanism of lung cancer causation induced by the interdependent coaction of asbestos fibers and tobacco smoke at a biological level is a multistage stochastic process with both agents acting conjointly at all times. The new knowledge gained through this review provides the evidence for synergism between asbestos exposure and tobacco smoke in lung cancer causation at a biological level. The evaluated statistical data conform best to a multiplicative model for the interaction effects of asbestos and smoking on the lung cancer risk, with no requirement for asbestosis. Any asbestos exposure, even in a heavy smoker, contributes to causation. Based on this information, we propose criteria for the attribution of lung cancer to asbestos in smokers and non-smokers.

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“…El Zoghbi et al (2017) reviewed the data on the interaction between DE exposure and tobacco smoking and concluded for the absence of multiplicative interaction. We expanded on this review by including a larger number of studies and conducting a meta-analysis of the results on interaction.…”

Section: Discussionmentioning

confidence: 99%

Interaction between occupational exposure to diesel exhaust and tobacco smoking in determining lung cancer risk: a meta-analysis

Rizzello

Pompiani

Violante

et al. 2021

European Journal of Cancer Prevention

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Background While an association between exposure to diesel exhaust (DE) and risk of lung cancer has been reported in several studies, its interaction with tobacco smoking in determining lung cancer risk is not well characterized. This study aims at performing a systematic review and meta-analysis of results of epidemiology studies on this. Methods Studies included in the systematic review were identified from PubMed, Scopus, and Embase, without limitation of year of publication or language. Two reviewers independently reviewed the studies and abstracted relevant data from selected studies, applied a customized quality assessment tool and calculated the relative risks (RRs) and 95% confidence intervals (CIs) for the interaction between DE exposure and tobacco smoking on a multiplicative scale. Next, a random-effects meta-analysis of the interaction RR was conducted. ResultsSeven studies were included in the metaanalysis, of which two were cohort and five case-control studies. Results on the interaction were heterogeneous (I 2 = 45.6%). The summary RR for interaction was 0.79 (95% CI, 0.42-1.46). There was no indication of publication bias. There was no increased risk of lung cancer among non-smoking workers exposed to DE. ConclusionsThis meta-analysis suggested a lessthan-multiplicative effect between DE exposure and tobacco smoking in determining lung cancer risk, but the hypothesis of multiplicative interaction cannot be rejected. The small number of relevant studies and the high heterogeneity among them prevent from definite conclusions.

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Absence of multiplicative interactions between occupational lung carcinogens and tobacco smoking: a systematic review involving asbestos, crystalline silica and diesel engine exhaust emissions

Cited by 9 publications

References 50 publications

Association of mesothelioma deaths with neighborhood asbestos exposure due to a large‐scale asbestos‐cement plant

Association of mesothelioma deaths with neighborhood asbestos exposure due to a large‐scale asbestos‐cement plant

Asbestos, Smoking and Lung Cancer: An Update

Interaction between occupational exposure to diesel exhaust and tobacco smoking in determining lung cancer risk: a meta-analysis

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