Absence of mesothelioma risk maintained in an expanded international cohort of cosmetic talc miners and millers

Ierardi, A. Michael; Marsh, Gary M.

doi:10.1080/08958378.2020.1781304

Cited by 12 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is despite the fact that an increased risk of NMRD has been observed in highly exposed New York talc miners and millers. The lack of mesothelioma risk in New York talc miners and millers is consistent with what has been observed in other talc miner and miller cohorts (Finley et al, 2017; Fordyce et al, 2019; Ierardi and Marsh 2020; Pira et al, 2017; Wergeland et al, 2017), as well as other cohorts exposed to amphibole cleavage fragments (Gamble and Gibbs 2008; Garabrant and Pastula 2018).…”

Section: Resultssupporting

confidence: 86%

A review of the mesotheliogenic potency of cleavage fragments found in talc

Miller,

Beckett,

Cheatham

et al. 2024

Toxicol Ind Health

View full text Add to dashboard Cite

It has long been recognized that amphibole minerals, such as cleavage fragments of tremolite and anthophyllite, may exist in some talc deposits. We reviewed the current state of the science regarding the factors influencing mesotheliogenic potency of cleavage fragments, with emphasis on those that may co-occur in talc deposits, including dimensional and structural characteristics, animal toxicology, and the most well-studied cohort exposed to talc-associated cleavage fragments. Based on our review, multiple lines of scientific evidence demonstrate that inhaled cleavage fragments associated with talc do not pose a mesothelioma hazard.

show abstract

Section: Resultssupporting

confidence: 86%

A review of the mesotheliogenic potency of cleavage fragments found in talc

Miller,

Beckett,

Cheatham

et al. 2024

Toxicol Ind Health

View full text Add to dashboard Cite

show abstract

“…Ierardi and Marsh ( 58 ) conducted a power analysis to determine whether the pooled cohorts could detect a true association between talc exposure and mesothelioma risk among talc miners and millers, if there were one. Based on 130,154 total person-years of follow-up across five cohorts, the authors estimated that the pooled cohorts ( 30 , 51 , 53 , 56 ) had 59% and 78% power to detect a 2.5-fold or greater and a 3.0-fold or greater increased risk of mesothelioma, respectively.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc

Lynch

Lauer

Thompson

et al. 2022

Front. Public Health

Self Cite

View full text Add to dashboard Cite

We conducted a systematic review to assess the potential pulmonary carcinogenicity of inhaled talc in humans. Our systematic review methods adhere to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and incorporated aspects from the US Institute of Medicine (IOM) and several United States (US) Environmental Protection Agency (EPA) frameworks for systematic reviews. A comprehensive literature search was conducted. Detailed data abstraction and study quality evaluation, adapting the US Toxic Substances Control Act (TSCA) framework, were central to our analysis. The literature search and selection process identified 23 primary studies that assessed exposure to talc and pulmonary cancer risks in humans (n = 19) and animals (n = 3). Integrating all streams of evidence according to the IOM framework yielded classifications of suggestive evidence of no association between inhaled talc and lung cancer and pleural mesothelioma at human-relevant exposure levels.

show abstract

“…For context, occupational epidemiology studies of highly exposed cosmetic talc miners and millers from Austria, France, Italy, Norway, and the U.S. (state of Vermont) demonstrated that these workers were not at an increased risk of mesothelioma (Finley et al, 2017; Garabrant and Pastula, 2018; Ierardi and Marsh, 2020; Ierardi et al, 2022; Marsh et al, 2019; Marsh and Ierardi, 2020). Zero cases of mesothelioma have been reported in all these cohorts except for the Vermont cosmetic talc miners and millers.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to cosmetic talc and mesothelioma in barbers, hairdressers, and cosmetologists: A systematic review of the epidemiology

Lewis,

Smith,

Krevanko

et al. 2023

Toxicol Ind Health

View full text Add to dashboard Cite

Inhalation exposure to cosmetic talc has generated much scientific debate regarding its potential as a risk factor for mesothelioma, a rare, but fatal cancer. Barbers, hairdressers, and cosmetologists have regularly used cosmetic talc-containing products, but the collective epidemiological evidence for mesothelioma in these occupations has yet to be described. As such, we conducted a systematic review of PubMed and the National Institute for Occupational Safety and Health’s (NIOSH) Numbered Publications list to identify original epidemiological literature reporting measures of association between these occupations and incidence of or death from mesothelioma. Literature screening was performed independently twice, the results of which were summarized and tabulated and underwent a review for their accuracy. A total of 12 studies met our inclusion criteria, including three cohort, six case–control, and three proportionate mortality/registration studies. The data from these studies were collected in 13 European and North American countries, spanning more than 50 years. We supplemented this review with queries of occupational mortality databases that are managed by the Washington State Department of Health and NIOSH for 26 U.S. states. Most findings were null and if statistically significant, nearly all showed an inverse relationship, indicative of a protective effect of these occupations on mesothelioma risk. Overall, the epidemiological evidence does not support an increased risk of mesothelioma for these occupations. This research fills an important data gap on the etiology of mesothelioma in barbers, hairdressers, and cosmetologists, and provides a benchmark for those with comparatively less exposure, such as non-occupational users of similar cosmetic talc-containing products.

show abstract

Absence of mesothelioma risk maintained in an expanded international cohort of cosmetic talc miners and millers

Cited by 12 publications

References 41 publications

A review of the mesotheliogenic potency of cleavage fragments found in talc

A review of the mesotheliogenic potency of cleavage fragments found in talc

Systematic review of the scientific evidence of the pulmonary carcinogenicity of talc

Occupational exposure to cosmetic talc and mesothelioma in barbers, hairdressers, and cosmetologists: A systematic review of the epidemiology

Contact Info

Product

Resources

About