Absence of Late Radiation Effects on Bone Marrow Stem Cells

Coggle, J.E.

doi:10.1080/09553008014551421

Cited by 10 publications

(9 citation statements)

References 14 publications

(2 reference statements)

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“…Under our control conditions these three parameters are relatively constant. The values of 8-16 × 103 WBC/~I blood, 18-26 x 106 BMC/femur and about 25 x 103 pluripotent stem cells/femur were of the same order of magnitude as that reported for other mouse strains (Shaposhnikov 1979;Coggle 1980; see also . After whole body irradiation with 1 Gy a marked reduction of the WBC and BMC was found only during the first days of the experiment but no longer after 1 week.…”

Section: X-irradiation Experimentssupporting

confidence: 63%

“…As Coggle (1980) showed, there are no detectable quantitative effects in the femoral CFU-S population once the irradiated mice have recovered to control values 3 weeks after the irradiation. His experiment lasted up to 15 months after whole body doses of up to 6 Gy.…”

Section: Discussionmentioning

confidence: 85%

“…This is indicated by the fact that the absolute number of nucleated bone marrow cells is age related, i.e. it rises during the course of the first few months of life of the mouse with enlargement of the bone marrow space (Coggle 1980).…”

Section: Discussionmentioning

confidence: 99%

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The action of azimexone on the cells of the hemopoietic system in mice, especially after damage with X-rays

Friedberg

Mengel

Schlick

1983

Radiat Environ Biophys

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Mice were exposed to single doses of whole body X-irradiation (1 - 2 - 4 Gy) or were treated with sulphur mustard (15 mg/kg body weight i.p.). This treatment caused a reduction of the pluripotent stem cells in the bone marrow, of the total count of nucleated bone marrow cells in the femora and of the WBC in the peripheral blood. The size distribution of the bone marrow cells showed three separate peaks. From the histological examination of the bone marrow of X-irradiated mice it was deduced that the first peak represents erythrocytes, the second lymphocytes and the third peak the precursors of red and white blood cells. Multiple doses (25 - 50 - 100 mg/kg body weight) of azimexone, an immunomodulating substance, led after moderate doses of X-rays (2 Gy) or sulphur mustard to a more rapid recovery of the various parameters. In particular a stimulant action of azimexone on the pluripotent stem cells of mice not subjected to the injurious agents could also be demonstrated.

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Section: X-irradiation Experimentssupporting

confidence: 63%

Section: Discussionmentioning

confidence: 85%

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The action of azimexone on the cells of the hemopoietic system in mice, especially after damage with X-rays

Friedberg

Mengel

Schlick

1983

Radiat Environ Biophys

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“…It is measured by the determination of the extra radiation dose, corrected for dose per fraction using the linear-quadratic equation, needed to compensate for the additional duration of treatment (Trott and Kummermehr 1993) and quantified in the unit gray per day. Except for very few special experimental systems in which stem cell regeneration can be measured directly (Hermens and Barendsen 1969, Coggle 1980, Blott and Trott 1989, there is no other way to measure accelerated repopulation. Any study that uses a different criterion has to demonstrate that similar results are also obtained when using this approach.…”

mentioning

confidence: 99%

Perspectives of experimental research on repopulation during radiotherapy

Trott

2003

International Journal of Radiation Biology

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“…Data on bone marrow CFU-s repopulation have main ly been based on studies of a single dose of either TBI [2,[11][12][13][14] or a chemotherapeutic drug [7,15], and primarily high doses have been used. The results in these studies can not be compared directly due to dilferences in experimen tal set-up and the use of different mouse strains.…”

Section: Discussionmentioning

confidence: 99%

Influence of Dose on Regeneration of Murine Hematopoietic Stem Cells after Total Body Irradiation and 5-Fluorouracil

Høyer¹,

Nielsen²

1992

Oncology

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The regeneration of murine bone marrow stem cells after treatment with 5-fluo-rouracil (5-FU) and total body irradiation (TBI) was investigated by means of the spleen colony assay. 5-FU was given intraperitoneally in doses ranging from 75 to 225 mg/kg body weight. TBI was administrated as a single fraction in the dose range 0.75-3.50 Gy. The frequency of stem cells declined rapidly and reached a minimum (nadir) on day 1-2 after either of the 2 treatments. Their number returned to near-pretreatment values by day 7-10. Increasing the dose of either 5-FU or TBI resulted in a lower nadir in stem cell survival and a higher regeneration rate of the stem cells. The maximal regeneration rate corresponded to a doubling time of 19 h. The time to complete regeneration was constant and neither influenced by the treatment modality nor by the dose. Both this work and previous studies on cyclophosphamide and combined 5-FU and TBI may indicate that the regeneration rate of bone marrow stem cells after a cytotoxic assault is influenced primarily by the stem cell surviving the treatment rather than the treatment modality.

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Absence of Late Radiation Effects on Bone Marrow Stem Cells

Cited by 10 publications

References 14 publications

The action of azimexone on the cells of the hemopoietic system in mice, especially after damage with X-rays

The action of azimexone on the cells of the hemopoietic system in mice, especially after damage with X-rays

Perspectives of experimental research on repopulation during radiotherapy

Influence of Dose on Regeneration of Murine Hematopoietic Stem Cells after Total Body Irradiation and 5-Fluorouracil

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