Absence of initial viral replication and long-term high dose immunoglobulin administration improve results of hepatitis B virus recurrence prophylaxis after liver transplantation

Comparison of Surgical Outcomes for Hepatocellular Carcinoma in Patients With Hepatitis B Versus Hepatitis C: A Western Experience

“…29,30 Several centers have reported improved survival after transplantation for HBV with the use of hepatitis B immune globulin. [35][36][37] Currently, transplant for HBV at our institution carries a prognosis that is better than the mean when all indications are considered. Mazzaferro et al 38 have established liver transplant as an effective treatment for small, unresectable HCC in cirrhotic patients.…”

Treatment of hepatitis B and C following liver transplantation

“…Subsequent studies have confirmed the benefit of longterm HBIG administration in decreased recurrence of HBV and improved survival [7,8]. These studies also confirmed that patients with evidence of active replication (ie, serum HBV DNA positive or hepatitis B early antigen [HBeAg] positive) at the time of OLT are at higher risk for the development of recurrent HBV, compared with those in a nonreplicative state.…”

Hepatitis B Infection and Liver Transplantation

“…Only two patients in this cohort were serum HBV DNA positive pretransplantation. At the recent XVI International Congress meeting held in Barcelona, a group from Nice reported an incredible five-year actuarial reinfection rate of only 7.59% in 112 patients, none of whom was replicating pretransplantation (32). A somewhat unusual characteristic of this patient cohort was that 72% (77 of 107) of the cirrhotic patients were delta agent seropositive.…”