Absence of influence of the Korean MELD score-based liver allocation system on pretransplant MELD score in patients undergoing living donor liver transplantation

Kim, Sang Hoon; Hwang, Shin; Ahn, Chul‐Soo; Moon, Deok‐Bog; Ha, Tae-Yong; Song, Gi-Won; Jung, Dong‐Hwan; Park, Gil‐Chun; Kim, Ki‐Hun; Yoon, Young‐In; Kang, Woo‐Hyoung; Cho, Hwui-Dong; Kim, Minjae; Na, Byeong-Gon; Kim, Sung-Min; Yang, Geunhyeok

doi:10.52604/alt.11.0002

Cited by 1 publication

(2 citation statements)

References 18 publications

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“…Result: Fig. 5 shows that FlashEval identifies an accurate saturation point (15) matching ground truth (15). In contrast, RS fails to find a saturation point in 20 steps due to continuous performance fluctuations.…”

Section: Use Cases Of Flashevalmentioning

confidence: 96%

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A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression

Zhao

Liu

et al. 2022

Preprint

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Clinical management of chronic hepatitis B (CHB) virus infection remains a big challenge and urges the development of novel therapeutics to achieve long-term virological control and seroconversion. In this study, we report on the development and evaluation of a highly efficacious therapeutic mRNA vaccine encoding the full-length hepatitis B virus (HBV) surface antigen (HBsAg). In pAAV-HBV1.2 and rAAV8-HBV1.3-transduced CHB mouse models, the HBV mRNA vaccine demonstrated potent therapeutic efficacy indicated by a complete serum viral clearance, a remarkable decline in intrahepatic HBcAg, viral DNA and RNA copies, as well as the induction of robust levels of anti-HBs antibodies, virus-specific T cells and memory B cells. In addition, the HBV mRNA vaccine induced strong innate immune activation, represented by the maturation of CD8α+ and CD103+ cDC1, CD11b+ cDC2, monocytes and neutrophils. Taken together, the HBV mRNA vaccine is a promising therapeutic candidate holding prospect for further development and clinical investigation.

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Section: Use Cases Of Flashevalmentioning

confidence: 96%

“…15 to 19, our acquired subsets achieves superior evaluation compared with the random sample baseline (adopted by recent literature Lee et al[41]) quality for different metrics across different model splits.…”

mentioning

confidence: 91%

A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression

Zhao

Liu

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

Absence of influence of the Korean MELD score-based liver allocation system on pretransplant MELD score in patients undergoing living donor liver transplantation

Cited by 1 publication

References 18 publications

A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression

A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression

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