Absence of immunoglobulin E synthesis and airway eosinophilia by vaccination with plasmid DNA encoding ProDer p 1

Jacquet, Alain; Magi, Mauro; Haumont, Michèle; Jurado, Margarita; Garcia, Lida; Bollen, Alex

doi:10.1046/j.1365-2222.2003.01584.x

Cited by 23 publications

(18 citation statements)

References 51 publications

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“…Similar results have been demonstrated with DNA vaccines encoding allergens of house dust mite [12,19,20,21,22,23] and a DNA vaccine coding for the major milk allergen bovine β-lactoglobulin [24]. …”

Section: Th1-biased Immunity – the Key To Dna-based Allergy Vaccinationsupporting

confidence: 76%

“…It is characterized by airway obstruction, mucus hypersecretion and inflammation of the airways, including infiltration and activation of eosinophils in the bronchial mucosa. Several publications showed that DNA-based vaccines offer an intriguing long-term solution to counteract the early events in allergic inflammation of the lung [13,19,20,21, 23,25,26,27,28]. …”

Section: Th1-biased Immunity – the Key To Dna-based Allergy Vaccinationmentioning

confidence: 99%

“…Because usually the codons of plant allergen genes are suboptimal concerning mammalian codon usage, protein expression in the mammalian host can be severely diminished. Several studies have proven that this problem can be solved by adapting the sequence of the allergen gene to mammalian codon usage [19, 21, 59]. …”

Section: Approaches To Optimize the Immunogenicity Of Allergy Gene Vamentioning

confidence: 99%

“…Compared with the wild-type gene, protein expression with the recoded gene was increased about 180 fold, and intradermal DNA immunization resulted in strong immunogenicity [59]. Similar approaches were made using plasmid DNA encoding the mite allergen precursor ProDer p 1 with optimized codon usage [19], and an optimized construct containing mouse Igĸ light chain leader sequence followed by codon optimized mature Der p 1 [21]. …”

Section: Approaches To Optimize the Immunogenicity Of Allergy Gene Vamentioning

confidence: 99%

See 3 more Smart Citations

Is Genetic Vaccination against Allergy Possible?

Weiss

Scheiblhofer

Gabler

et al. 2006

Int Arch Allergy Immunol

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Genetic immunization has proven a powerful method to induce antiallergic immune responses. The underlying functional principle has been described to be based on the recruitment of allergen-specific Th1 cells, CD8+ cells and the establishment of a Th1 cytokine milieu, which prevent the development of a Th2-biased response in a protective setup and can balance an ongoing Th2-type response in a therapeutic situation. Genetic immunization with plasmid DNA offers innovative solutions to the major problems associated with protein immunization, such as crosslinking of pre-existing immunoglobulin E on mast cells/basophils or induction of de novo synthesis of immunoglobulin E by the protein immunization itself. It easily enables the routine production of hypoallergenic vaccines, which do not translate native allergens, thus avoiding potential anaphylactic side effects. DNA vaccines can also be applied as mixtures of single vaccines, making them interesting candidates for treatment based on component-resolved diagnosis, followed by an individualized therapy with the relevant allergens. In addition to the description of up-to-date allergen gene vaccine approaches, this review gives an overview of animal studies dealing with the following topics: danger signals as the inherent adjuvant properties, methods to optimize the vaccine immunogenicity, modulation of the immune response, nonparenteral applications and low-dose vaccination strategies.

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Section: Th1-biased Immunity – the Key To Dna-based Allergy Vaccinationsupporting

confidence: 76%

Section: Th1-biased Immunity – the Key To Dna-based Allergy Vaccinationmentioning

confidence: 99%

Section: Approaches To Optimize the Immunogenicity Of Allergy Gene Vamentioning

confidence: 99%

Section: Approaches To Optimize the Immunogenicity Of Allergy Gene Vamentioning

confidence: 99%

See 2 more Smart Citations

Is Genetic Vaccination against Allergy Possible?

Weiss

Scheiblhofer

Gabler

et al. 2006

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…In den darauf folgenden Jahren wurden DNA-Vakzine gegen eine Reihe von Modellmolekülen und klinisch relevanten Allergenen entwickelt [26][27][28][29][30][31][32]. Zu den diesbezüglich am besten untersuchten Allergenen gehört das Hauptallergen der Birkenpollen, Bet v 1, gegen das 1999 erstmals genetisch immunisiert wurde [17,[33][34][35][36].…”

Section: Erste Studien Zur Genetischen Immunisierung Gegen Allergieunclassified

Genetic immunization: new ways for protective and therapeutic vaccines against allergic diseases

Scheiblhofer

Weiss

Thalhamer

2007

Wien Med Wochenschr

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Gene vaccines have proven to be a powerful tool to induce anti-allergic immune responses. Their underlying functional principle is based on the recruitment of allergen-specific Th1 cells and the establishment of a Th1 cytokine milieu, which protects against the development of a Th2-biased response and balances an already ongoing Th2-type response. Genetic immunization also offers novel approaches to the major problems associated with protein immunization, such as crosslinking of preexisting IgE on mast cells/basophils or induction of de novo synthesis of IgE by the protein immunization itself. In addition to the description of the principles of gene vaccination, this review gives a short overview of recently developed anti-allergic gene vaccines with an optimized efficacy and safety profile.

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DNA and RNA Vaccines for Prophylactic and Therapeutic Treatment of Type I Allergy

et al. 2011

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Absence of immunoglobulin E synthesis and airway eosinophilia by vaccination with plasmid DNA encoding ProDer p 1

Abstract: These results suggest that vaccination with DNA encoding ProDer p 1 effectively fails to induce the allergen-induced IgE synthesis and airway cell infiltration. Plasmid DNA encoding ProDer p 1 may provide a novel approach for the treatment of house dust mite allergy.

Cited by 23 publications

References 51 publications

Is Genetic Vaccination against Allergy Possible?

Is Genetic Vaccination against Allergy Possible?

Genetic immunization: new ways for protective and therapeutic vaccines against allergic diseases

DNA and RNA Vaccines for Prophylactic and Therapeutic Treatment of Type I Allergy

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