Absence of human herpesvirus-8 in pulmonary inflammatory myofibroblastic tumor: immunohistochemical and molecular analysis of 20 cases

Távora, Fábio; Shilo, Konstantin; Özbudak, İrem Hicran; Przybocki, Jean M; Wang, Guanghua; Travis, William D.; Franks, Teri J.

doi:10.1038/modpathol.3800938

Cited by 27 publications

(7 citation statements)

References 25 publications

(30 reference statements)

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“…In addition, the lesional cells of inflammatory myofibroblastic tumors may show positive immunolabeling with ALK and HHV-8. 24 In each of the 3 cases studied in our series, ALK and HHV-8 immunohistochemical staining were negative. Cases of SANT have been described showing EBER1-positive stromal cells, suggesting a relation with inflammatory myofibroblastic tumors.…”

Section: Discussionmentioning

confidence: 95%

Sclerosing Angiomatoid Nodular Transformation (SANT) of the Spleen: A Report of 3 Cases

et al. 2009

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The authors describe 3 cases of sclerosing angiomatoid nodular transformation (SANT) of the spleen diagnosed at Memorial Sloan-Kettering Cancer Center within a 1-year period (July 2008 to June 2009). All patients were female, older than 50, with lesions ranging in size from 2 to 4 cm. All were alive and well after splenectomy. All the cases showed characteristic histological and immunophenotypical findings as previously described in the literature, including scattered IgG4positive plasma cells in the fibrosclerotic stroma. Of the 3 patients, 2 had a history of carcinoma, and metastasis was of concern, but a PET scan in one of these patients showed minimal to absent FDG activity suggesting that this process was of a benign indolent nature. However, in 1 patient, a PET scan revealed positive FDG activity, heightening clinical concern for malignancy.

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Section: Discussionmentioning

confidence: 95%

Sclerosing Angiomatoid Nodular Transformation (SANT) of the Spleen: A Report of 3 Cases

et al. 2009

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“…The biologic behavior is intermediate, with potential for local recurrence and rare distant metastasis (45). Molecular rearrangements of the anaplastic lymphoma kinase locus on chromosome 2p23 manifest in 50% or more of cases of IMTs in general (46); however, this may be less true in pulmonary IMT (47). Support for a reactive inflammatory process includes an association with prior respiratory infection in up to 20% of cases and isolation of DNA from human herpesvirus 8 from pulmonary IMT (1,48,49).…”

Section: Lung Tumors In Children Inflammatory Myofibroblastic Tumormentioning

confidence: 99%

Primary Lung Tumors in Children: Radiologic-Pathologic CorrelationFrom the Radiologic Pathology Archives

Lichtenberger¹,

Biko²,

Carter³

et al. 2018

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Primary lung tumors in children are rare, with a narrow range of diagnostic considerations. However, the overlapping imaging appearances of these tumors necessitate attention to key discriminating imaging and pathologic features. In the neonate and infant, the important considerations include pleuropulmonary blastoma (PPB), infantile fibrosarcoma, and fetal lung interstitial tumor. Among these tumors, imaging findings such as air-filled cysts in type 1 PPB and homogeneously low attenuation of fetal lung interstitial tumors are relatively specific. Key pathologic and genetic discriminators among this group of tumors include the DICER1 germline mutation found in PPB and the t(12,15)(p13;q25) translocation and ETV6-NTRK3 fusion gene seen in infantile fibrosarcoma. Primary lung tumors in older children include inflammatory myofibroblastic tumors (IMTs), carcinoid salivary gland-type tumors of the lung, recurrent respiratory papillomatosis, and other rare entities. IMT, a spindle-cell proliferation with inflammatory elements, is the most common lung tumor in children. Anaplastic lymphoma kinase, a receptor-type protein tyrosine kinase, is present in 50% of these tumors, and this finding may support an imaging diagnosis of IMT. Carcinoid tumors account for a substantial portion of childhood lung tumors, and their characteristic avid enhancement on images corresponds to the compressed fibrovascular stroma histologically. Furthermore, novel imaging agents used with somatostatin receptor analogs have an emerging role in the evaluation of carcinoid tumors. Although less common than mucoepidermoid carcinoma, adenoid cystic carcinoma tends to recur given the perineural spread seen histologically. Integrating radiologic and pathologic knowledge is critical to accurate diagnosis, treatment planning, and surveillance of primary lung tumors in children.Abbreviations: CPAM = congenital pulmonary airway malformation, FDG = fluorodeoxyglucose, FLIT = fetal lung interstitial tumor, GLUT1 = glucose transporter 1, IMT = inflammatory myofibroblastic tumor, NUT = nuclear protein in testis, PPB = pleuropulmonary blastoma, RRP = recurrent respiratory papillomatosis

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“…These lesions are generally composed of a proliferation of spindled myofibroblasts set in a background of densely hyalinized collagenous tissue with an inflammatory infiltrate. 6,10 This infiltrate is often composed primarily of plasma cells, and the stroma may exhibit a whorled or laminated appearance. 6 Both the cellular and stromal components of these lesions can display quite variable morphologies, sometimes difficult to distinguish from low grade sarcoma in small tissue samples.…”

Section: Discussionmentioning

confidence: 99%

“…The infectious theory is supported by a number of observations, namely the identification of viral DNA (Epstein–Barr virus, human herpesvirus-8) within some lesions, their occurrence concurrent with or shortly following infection, and the resolution of symptoms following antibiotic treatment in some cases. 10,11 Numerous intra-abdominal cases have also been reported to occur in response to foreign bodies, such as food particles and retained surgical materials. 7 A subset of inflammatory pseudotumors (inflammatory myofibroblastic tumors) is believed to be neoplastic, as evidenced by cytogenetic aberrations, especially involving the ALK gene.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Pseudotumor Containing Kayexalate Crystals

Romano

Thirumala²,

Cushman

et al. 2013

Int J Surg Pathol

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Kayexalate (sodium polystyrene sulfonate), a cation exchange resin often used to treat hyperkalemia, is known to produce gastrointestinal complications in a minority of patients. These complications range from mild gastrointestinal bleeding to perforation with acute abdomen. The typical histopathologic findings include mucosal ulceration, necrosis, and the presence of polygonal basophilic refractile crystals with a "fish scale" appearance. We present a unique case of Kayexalate crystals embedded in a perihepatic inflammatory pseudotumor, developing adjacent to a colostomy site in a 62-year-old woman following Kayexalate treatment. Microscopically, the lesion demonstrated a myofibroblastic proliferation rich in histiocytes and inflammation (lymphocytes, plasma cells, and eosinophils) as well as the presence of scattered typical Kayexalate crystals. This is the first report of extraintestinal Kayexalate identification in association with an inflammatory pseudotumor.

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Absence of human herpesvirus-8 in pulmonary inflammatory myofibroblastic tumor: immunohistochemical and molecular analysis of 20 cases

Cited by 27 publications

References 25 publications

Sclerosing Angiomatoid Nodular Transformation (SANT) of the Spleen: A Report of 3 Cases

Sclerosing Angiomatoid Nodular Transformation (SANT) of the Spleen: A Report of 3 Cases

Primary Lung Tumors in Children: Radiologic-Pathologic CorrelationFrom the Radiologic Pathology Archives

Inflammatory Pseudotumor Containing Kayexalate Crystals

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